Chronotype and Cancer: Emerging Relation Between Chrononutrition and Oncology from Human Studies

Nutrients, Год журнала: 2025, Номер 17(3), С. 529 - 529

Опубликована: Янв. 31, 2025

Fasting-feeding timing is a crucial pattern implicated in the regulation of daily circadian rhythms. The interplay between sleep and meal underscores importance maintaining alignment order to avoid creating metabolic environment conducive carcinogenesis following molecular systemic disruption performance immune function. chronicity such condition may support initiation progression cancer through variety mechanisms, including increased oxidative stress, suppression, activation proliferative signaling pathways. This review aims summarize current evidence from human studies provide an overview potential mechanisms underscoring role chrononutrition (including time-restricted eating) on risk. Current shows that morning chronotype, suggesting physiological rhythms eating timing, associated with lower risk cancer. Also, early prolonged nighttime fasting were also suggests chronotype influences cell cycle regulation, modulation pathways inflammation, gut microbiota fluctuations. In conclusion, although there are no clear guidelines this matter, emerging supports hypothesis time-related (i.e., time/calorie-restricted feeding intermittent/periodic fasting) could potentially lead reduced

Язык: Английский

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Enhancing glioblastoma therapy: unveiling synergistic anticancer effects of Onalespib - radiotherapy combination therapy

Frontiers in Oncology, Год журнала: 2025, Номер 15

Опубликована: Янв. 30, 2025

Background Glioblastoma (GBM) is the deadliest form of brain cancer, impacting both adults and children, marked by exceptionally high morbidity mortality rates, even with current standard treatments such as surgery, radiation therapy, chemotherapy. Therefore, there a pressing need for new therapeutic strategies to improve survival reduce treatment side effects. In this study, we investigated effect HSP90 inhibition in combination radiotherapy established patient-derived glioblastoma cell lines. Methods Potential radiosensitizing effects inhibitor Onalespib were studied XTT clonogenic assays well tumor-mimicking multicellular spheroid models. Further, migration capacity on protein expression after exposure using Proximity Extension Assay analysis. Results synergistically enhanced radiosensitivity cells grown 2D 3D models, resulting increased death, reduced activation apoptotic signaling pathway. The proteomic analysis treated Onalespib, radiation, their revealed significant alterations profiles, involved growth signaling, immune modulation pathways angiogenesis. Moreover, indicated potential enhancing cycle arrest apoptosis, suggesting promising anti-tumor Conclusion These findings demonstrate that may be strategy enhance efficacy GBM, potentially leading improved outcomes patients battling challenging disease.

Язык: Английский

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Study on the Effects and Mechanism of Corilagin on A2780 Cell Apoptosis

Current Issues in Molecular Biology, Год журнала: 2025, Номер 47(2), С. 105 - 105

Опубликована: Фев. 7, 2025

Previous studies have demonstrated corilagin's inhibitory effects on the growth of various cancer cells. Given limited research impact ovarian cancer, a particularly deadly gynecological malignancy, this study aimed to investigate influence A2780 cell apoptosis and its underlying mechanisms. The goal was evaluate potential as therapeutic agent for cancer. results CCK-8 assay showed that corilagin inhibited proliferation cells while exhibiting lower toxicity normal surface epithelial (IOSE-80). We found significantly altered cycle, decreasing proportion in G0/G1 G2/M phases inducing cycle arrest S phase. At low concentrations, induced cells, accompanied by decline mitochondrial membrane calcium influx. Transcriptome sequencing analysis identified differentially expressed apoptosis-related genes corilagin-treated primarily within PI3K-AKT pathway. Furthermore, qPCR Western blot confirmed upregulation p53 Bax downregulation BCL-2. Corilagin also increased expression apoptotic factors caspase-9, caspase-3, PUMA, cytochrome C, indicating ability induce apoptosis. Overall, effectively proliferation, arrest, triggered Its anti-tumor effect vitro suggests A2780, especially through PI3K/p53

Язык: Английский

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Lathyrol inhibits the proliferation of renca cells by affecting the expression of TGF-β/smad pathway and then affecting the cell cycle

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Март 3, 2025

Background Renal cell carcinoma (RCC) is a prevalent malignant tumor with high morbidity and mortality. The TGF-β/smad signaling pathway plays significant role in the development progression of RCC. Methods This study explored impact lathyrol on proliferation mice RCC renca cells by inhibiting arresting cycle. Bioinformatics analysis, culture experiments, animal experiments were conducted to detect effects activity, mRNA, protein expressions xenograft tumors, as well cycle proteins regulatory proteins. Results Lathyrol treatment showed positive correlation inhibitory effect proliferation. IC values 786-O comparable. In vitro, decreased mRNA TGF-β1, TGF-βR1, smad2, smad3, smad4, smad9, while increasing smad4. vivo, suppressed smad9 xenografts, cyclinD1, cyclinB1, cyclinA1, cyclinE1, CDK6, CDK4, CDK1, P16, P21, P27. Conclusion can repress expression key pathway, impede signal transduction, arrest cells, subsequently inhibit cells. Future studies are needed further explore mechanism treatment.

Язык: Английский

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Exploring druggable targets and inflammation-mediated pathways in cancer: a Mendelian randomization analysis integrating transcriptomic and proteomic data

Inflammation Research, Год журнала: 2025, Номер 74(1)

Опубликована: Март 4, 2025

Язык: Английский

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Experimental Validation of miR-4443, miR-572, and miR-150-5p in Serum and Tissue of Breast Cancer Patients as a Potential Diagnostic Biomarker: A Study Based on Bioinformatics Prediction

Biochemical Genetics, Год журнала: 2025, Номер unknown

Опубликована: Март 10, 2025

Язык: Английский

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Risks of respiratory and circulatory system diseases induced by exposure to PM2.5 in high humidity and low solar radiation environments: disease types, genes, and functions

Environmental Geochemistry and Health, Год журнала: 2025, Номер 47(5)

Опубликована: Апрель 6, 2025

Язык: Английский

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Deciphering the Immune Microenvironment at the Forefront of Tumor Aggressiveness by Constructing a Regulatory Network with Single-Cell and Spatial Transcriptomic Data

Genes, Год журнала: 2024, Номер 15(1), С. 100 - 100

Опубликована: Янв. 15, 2024

The heterogeneity and intricate cellular architecture of complex ecosystems play a crucial role in the progression therapeutic response cancer. Understanding regulatory relationships malignant cells at invasive front tumor microenvironment (TME) is important to explore TME its disease progression. In this study, we inferred invasion by analyzing single-cell RNA sequencing (scRNA-seq) spatial transcriptomics (ST) data ER-positive (ER+) breast cancer patients. addition, developed software pipeline for constructing intercellular gene networks (IGRNs), which help reduce errors generated communication analysis increase confidence selected cell signals. Based on constructed IGRN between immune ER+ patients, found that high expression transcription factors FOXA1 EZH2 played key driving Meanwhile, elevated levels their downstream target genes (ESR1 CDKN1A) were associated with poor prognosis This study demonstrates bioinformatics workflow combining scRNA-seq ST data; provides pipelines IGRNs automatically (cIGRN). strategy will decipher revealing bidirectional signaling frontline cells, molecules network may serve as biomarkers mechanism studies or targets.

Язык: Английский

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Double-Edged Sword Effect of Diet and Nutrition on Carcinogenic Molecular Pathways in Breast Cancer

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(20), С. 11078 - 11078

Опубликована: Окт. 15, 2024

Environmental exposure to a mixture of chemical xenobiotics acts as double-edged sword, promoting or suppressing tumorigenesis and the development breast cancer (BC). Before anything else, we are what eat. In this review, highlight both “the good” bad” sides daily human diet dietary patterns that could influence BC risk (BCR) incidence. Thus, regularly eating new, diversified, colorful, clean, nutrient-rich, energy-boosting, raw food, increases apoptosis autophagy, antioxidation, cell cycle arrest, anti-inflammation, immune response against cells. Moreover, healthy lead reduction in inhibition genomic instability, stemness, growth, proliferation, invasion, migration, distant metastasis. We also emphasize that, addition beneficial compounds, our food is more contaminated by chemicals with harmful effects, which interact each other endogenous proteins lipids, resulting synergistic antagonistic effects. diverse diet, combined appropriate nutritional behaviors, can exert anti-carcinogenic effects improve treatment efficacy, patient outcomes, overall quality life patients.

Язык: Английский

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Study on the Effects and Mechanism of Corilagin on A2780 Cell Apoptosis

Опубликована: Авг. 8, 2024

Previous studies found that corilagin inhibits the growth of many cancer cells. Ovarian is deadliest gynecological malignancy, but research on effects ovarian limited. This experiment aims to explore impact A2780 cell apoptosis and its mechanism action evaluate prospects in treating cancer. Corilagin significantly affects cycle, reducing proportion G0/G1 G2/M phase cells blocking them S phase. at low concentrations can cause apoptosis, mitochondrial membrane potential decline, calcium influx. After were stained with Acridine Orange, autophagosomes observed under a fluorescence microscope increased increase concentration. The results transcriptome sequencing showed effect could differential expression apoptosis-related genes concentrated PI3K-AKT pathway. qPCR P53 Bax while BCL-2 decreased. expressions apoptotic factors caspase-9, caspase-3, p53-upregulated modulator (PUMA), cytochrome C after corilagin, indicating induce apoptosis. effectively inhibit proliferation cells, cycle arrest, Moreover, it trigger autophagy has vitro antitumor effects. It promising drug for through PI3K/P53

Язык: Английский

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