Sleep, Glial Function, and the Endocannabinoid System: Implications for Neuroinflammation and Sleep Disorders
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(6), С. 3160 - 3160
Опубликована: Март 9, 2024
The
relationship
between
sleep,
glial
cells,
and
the
endocannabinoid
system
represents
a
multifaceted
regulatory
network
with
profound
implications
for
neuroinflammation
cognitive
function.
molecular
underpinnings
of
sleep
modulation
by
its
influence
on
cell
activity
are
discussed,
shedding
light
reciprocal
relationships
that
govern
these
processes.
Emphasis
is
placed
understanding
role
cells
in
mediating
neuroinflammatory
responses
their
patterns.
Additionally,
this
review
examines
how
interfaces
glia-immune
signaling
to
regulate
inflammatory
cascades
within
central
nervous
system.
Notably,
consequences
disrupted
neuroinflammation,
dysfunction
addressed,
encompassing
neurodegenerative
disorders,
mood
disturbances,
decline.
Insights
into
bidirectional
function
context
explored,
providing
comprehensive
perspective
potential
mechanisms
underlying
impairments
associated
disturbances.
Furthermore,
therapeutic
avenues
targeting
mitigate
restore
homeostasis,
normalize
identification
novel
targets
intricate
holds
promise
addressing
conditions
characterized
dysfunction.
This
work
aims
examine
complexities
neural
regulation
identify
intervention.
Язык: Английский
The Dose-Dependent Effects of Fluorocitrate on the Metabolism and Activity of Astrocytes and Neurons
Brain Sciences,
Год журнала:
2025,
Номер
15(2), С. 99 - 99
Опубликована: Янв. 21, 2025
Background:
Fluorocitrate
(FC)
ranging
from
5
μM
to
mM
is
often
used
as
a
specific
metabolic
inhibitor
of
the
astrocytes
study
astrocytic
functions.
Whether
FC
at
such
concentrations
may
affect
neuronal
metabolism
and
function
in
vivo
remains
unclear.
Methods:
We
examined
effects
on
ATP
levels
Ca2+
activity
neurons
motor
cortices
living
mice
using
two-photon
microscopy.
Results:
found
that
25
250
decreased
intracellular
cortex.
Equally,
FC,
but
not
reduced
dendritic
processes
layer
pyramidal
neurons.
However,
increased
activity,
whereas
≥250
it.
To
test
whether
differential
reflect
direct
effect
or
its
indirect
astrocytes,
we
CNO-hM3Dq
chemogenetic
approach
block
FC.
In
absence
still
neurons,
respectively,
suggesting
inhibiting
activity.
Further,
μM,
size
spines
over
2
h.
Conclusions:
Our
findings
suggest
high
(≥250
μM)
functions,
it
directly
affects
synaptic
plasticity
vivo.
Язык: Английский