Inorganica Chimica Acta, Год журнала: 2025, Номер unknown, С. 122584 - 122584
Опубликована: Фев. 1, 2025
Язык: Английский
Life Sciences, Год журнала: 2024, Номер 352, С. 122899 - 122899
Опубликована: Июль 9, 2024
This comprehensive review provides an in-depth analysis of how nanotechnology has revolutionized cancer theragnostic, which combines diagnostic and therapeutic methods to customize treatment. The study examines the unique attributes, uses, difficulties linked different types nanoparticles, including gold, iron oxide, silica, Quantum dots, Carbon nanotubes, liposomes, in context In addition, paper progression nanotheranostics, emphasizing its uses precise medication administration, photothermal therapy, sophisticated such as MRI, CT, fluorescence imaging. Moreover, article highlights capacity nanoparticles improve effectiveness drugs, reduce overall toxicity body, open up new possibilities for treating by releasing drugs a controlled manner targeting specific areas. Furthermore, it tackles concerns regarding compatibility their potential harmful effects, significance continuous nanotherapeutic use medical treatments. finishes outlining future applications predictive oncology customized medicine.
Язык: Английский
Процитировано
60
Journal of Food Science, Год журнала: 2025, Номер 90(1)
Опубликована: Янв. 1, 2025
Compared to traditional preservatives, photodynamic inactivation (PDI) offers a promising bactericidal approach due its nontoxic nature and low propensity for microbial resistance. In this paper, we initially investigate the principles antibacterial mechanisms underlying PDI. We then review factors influencing PDI's germicidal efficacy in food preservation. Furthermore, delve into application potential of PDI nanomaterials, such as quantum dots, titanium dioxide, graphene, packaging films. Special attention is given impact treatment on quality tolerance development. Last, discuss migration safety nanomaterials. The chemical basis involves generation reactive oxygen species through activation endogenous or exogenous photosensitizers. Its primary encompass disruption cell membranes, impairment cellular functions, inhibition quorum sensing. multi-target action significantly reduces likelihood resistance has great field packaging. information contained paper will provide effective reference design new
Язык: Английский
Процитировано
2
Journal of Functional Biomaterials, Год журнала: 2025, Номер 16(1), С. 24 - 24
Опубликована: Янв. 14, 2025
Autoimmune diseases present complex therapeutic challenges due to their chronic nature, systemic impact, and requirement for precise immunomodulation avoid adverse side effects. Recent advancements in biodegradable stimuli-responsive nanomaterials have opened new avenues targeted drug delivery systems capable of addressing these challenges. This review provides a comprehensive analysis state-of-the-art nanocarriers such as polymeric nanoparticles, liposomes, hydrogels engineered autoimmune therapies. These are designed degrade safely the body while releasing agents response specific stimuli, including pH, temperature, redox conditions, enzymatic activity. By achieving localized controlled release anti-inflammatory immunosuppressive agents, minimize toxicity enhance efficacy. We discuss underlying mechanisms nanomaterials, recent applications treating rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, design considerations essential clinical translation. Additionally, we address current challenges, biocompatibility, scalability, regulatory hurdles, well future directions integrating advanced nanotechnology with personalized medicine treatment. highlights transformative potential presenting them promising strategy advance precision improve patient outcomes disease management.
Язык: Английский
Процитировано
2
Results in Chemistry, Год журнала: 2024, Номер 10, С. 101715 - 101715
Опубликована: Авг. 1, 2024
Язык: Английский
Процитировано
12
Heliyon, Год журнала: 2024, Номер 10(7), С. e28942 - e28942
Опубликована: Март 31, 2024
Ferroptosis is an iron-dependent programmed cell death modality, which has showed great potential in anticancer treatment. Photodynamic therapy (PDT) widely used clinic as therapy. PDT combined with ferroptosis-promoting been found to be a promising strategy improve anti-cancer efficacy. Fenton reaction ferroptosis can provide oxygen for PDT, and produce reactive species enhance ferroptosis. In this review, we briefly present the importance of treatment, mechanism ferroptosis, researches on induced synergistic effect cancer killing.
Язык: Английский
Процитировано
10
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(7), С. 3811 - 3811
Опубликована: Март 29, 2024
The persistent failure of standard chemotherapy underscores the urgent need for innovative and targeted approaches in cancer treatment. Photodynamic therapy (PDT) has emerged as a promising photochemistry-based approach to address chemoresistance regimens. PDT not only induces cell death but also primes surviving cells, enhancing their susceptibility subsequent therapies. This review explores principles discusses concept photodynamic priming (PDP), which augments effectiveness treatments like chemotherapy. Furthermore, integration nanotechnology precise drug delivery at right time location optimization are examined. Ultimately, this study highlights potential limitations PDP treatment paradigms, offering insights into future clinical applications.
Язык: Английский
Процитировано
8
Drug Design Development and Therapy, Год журнала: 2024, Номер Volume 18, С. 2485 - 2529
Опубликована: Июнь 1, 2024
Abstract: Ferroptosis, a unique form of programmed cell death, is initiated by an excess iron accumulation and lipid peroxidation-induced damage. There growing body evidence indicating that ferroptosis plays critical role in the advancement tumors. The increased metabolic activity higher levels tumor cells make them particularly vulnerable to ferroptosis. As result, targeted induction becoming increasingly promising approach for cancer treatment. This review offers overview regulatory mechanisms ferroptosis, delves into mechanism action traditional small molecule inducers their effects on various In addition, latest progress inducing using new means such as proteolysis-targeting chimeras (PROTACs), photodynamic therapy (PDT), sonodynamic (SDT) nanomaterials summarized. Finally, this discusses challenges opportunities development ferroptosis-inducing agents, focusing discovering targets, improving selectivity, reducing toxic side effects. Keywords: inducers, molecules, PROTACs, PDT, SDT,
Язык: Английский
Процитировано
8
Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
This review discusses the recent developments in copper-based nanomaterials that utilize copper-induced cell death, categorized by materials systems, while highlighting limitations of current cuproptosis related nanomaterials.
Язык: Английский
Процитировано
1
Discover Nano, Год журнала: 2025, Номер 20(1)
Опубликована: Янв. 30, 2025
Abstract Osteosarcoma (OS) is distinguished as a high-grade malignant tumor, characterized by rapid systemic metastasis, particularly to the lungs, resulting in very low survival rates. Understanding complexities of tumor development and mutation need hour for advancement targeted therapies cancer care. A significant innovation this area use nanotechnology, specifically nanoparticles, tackle various challenges treatment. Iron oxide nanoparticles stand out both therapeutic diagnostic applications, offering versatile platform drug delivery, hyperthermia, magneto-thermal therapy, combinational therapy using modulation ferroptosis pathways. These are easy synthesize, non-toxic, biocompatible, display enhanced circulation time within system. They can also be easily conjugated anti-cancer drugs, targeting agents, or genetic vectors that respond specific stimuli pH changes. The surface functionalization these bioactive molecules unveils promising effective nanoparticle system assisting osteosarcoma therapy. This review will summarize current conventional their disadvantages, synthesis modification iron documented literature, cellular uptake mechanism, with focus on natural biomaterials application strategies towards management osteosarcoma. compiles translational future prospects must addressed clinical advancements based treatment future. Graphical abstract
Язык: Английский
Процитировано
1
Journal of Controlled Release, Год журнала: 2025, Номер 380, С. 125 - 137
Опубликована: Фев. 5, 2025
Язык: Английский
Процитировано
1