Inorganica Chimica Acta, Год журнала: 2025, Номер unknown, С. 122584 - 122584
Опубликована: Фев. 1, 2025
Язык: Английский
Cellular Signalling, Год журнала: 2024, Номер 122, С. 111329 - 111329
Опубликована: Авг. 5, 2024
Язык: Английский
Процитировано
7
Fishes, Год журнала: 2024, Номер 9(3), С. 99 - 99
Опубликована: Март 5, 2024
Increased infectious diseases and the reduced effectiveness of antibiotics due to antimicrobial resistance pose global challenges affecting aquaculture industry. As bacteria increasingly develop antibiotic resistance, research scientists are shifting their focus technologies such as photodynamic therapy (aPDT), which show potential for treating controlling fish infections without promoting development resistant bacteria. Various photosensitizers (PSs), both natural synthetic, under investigation application in aPDT within This shift is crucial sustainability industry, plays a significant role achieving several United Nations (UN) Sustainable Development Goals (SDGs). review highlights against pathogens industry types PSs utilized. It also explores this technique infections, along with advantages limitations its use production systems. Finally, conclusion future perspectives provided.
Язык: Английский
Процитировано
6
International Journal of Nanomedicine, Год журнала: 2024, Номер Volume 19, С. 5637 - 5680
Опубликована: Июнь 1, 2024
Abstract: Photodynamic therapy (PDT) is a non-invasive that has made significant progress in treating different diseases, including cancer, by utilizing new nanotechnology products such as graphene and its derivatives. Graphene-based materials have large surface area photothermal effects thereby making them suitable candidates for PDT or photo-active drug carriers. The remarkable photophysical properties of derivates facilitate the efficient generation reactive oxygen species (ROS) upon light irradiation, which destroys cancer cells. Surface functionalization can also enhance their biocompatibility anticancer activity. paper delves into distinct roles played graphene-based photosensitizers (PS) carriers while at same time considers how these could be used to circumvent resistance. This will provide readers with an extensive discussion various pathways contributing inefficiency. Consequently, this comprehensive review underscores vital derivatives may play emerging strategies treatment other medical purposes. With better comprehension current state research existing challenges, integration holds great promise developing targeted, effective, personalized treatments. Keywords: quantum dots, oxide, research, photosensitizers, delivery
Язык: Английский
Процитировано
6
Neuroscience, Год журнала: 2024, Номер 553, С. 1 - 18
Опубликована: Июнь 27, 2024
Язык: Английский
Процитировано
5
European Journal of Inorganic Chemistry, Год журнала: 2025, Номер unknown
Опубликована: Фев. 18, 2025
Abstract Difficulties to abate the vehemence of deleterious triple‐negative breast cancer (TNBC) is an ardent issue in current context anticancer research due lack a selective treatment modality. To address this issue, herein we have endeavored establish imidazophenanthroline‐based Ir(III)‐cyclometallated heteroleptic complexes, suited for one‐photon photodynamic therapy (OP‐PDT) under irradiation visible light (400–700 nm) possessing long‐lived excited triplet state and significant photostability. Among three synthesized [ L1Ir ], L2Ir L3Ir complex ] has been recognized as most competent exhibit phototoxicity (IC 50 =3.8 μ M; PI c =78.94) MDA‐MB‐231 cells. The complexes arisen production reactive singlet oxygen ( 1 O 2 ) following type‐II pathway (Φ s =0.26). Also, shown proficiency oxidation reduced nicotinamide adenine dinucleotide (NADH) (TOF=4.35 h −1 indicating possibility species (O ⋅ − , ⋅OH) generation through type‐I upon irradiation. Along with this, intracellular glutathione (GSH) depletion capabilities endued unarm TNBC cells front profuse amount ROS instigating programmed cell death (PCD) substantial DNA damage.
Язык: Английский
Процитировано
0
Inorganic Chemistry Frontiers, Год журнала: 2024, Номер 11(13), С. 3855 - 3876
Опубликована: Янв. 1, 2024
A new generation of benzimidazole-based cyclometalated ruthenium( ii ) complexes with bpy or dpq as ancillary ligands are effective against hypoxic cancers via green light activation and can directly disrupt phospholipid membranes trigger oncosis.
Язык: Английский
Процитировано
4
Drug Discovery Today, Год журнала: 2024, Номер 29(8), С. 104099 - 104099
Опубликована: Июль 11, 2024
Язык: Английский
Процитировано
4
Scientific Reports, Год журнала: 2024, Номер 14(1)
Опубликована: Окт. 29, 2024
Treating lung and prostate cancer cells is a major health problem that may be solved through the interactions of laser beams with nanoparticles. In paper, Au-H2Ti3O7 nanotubes (NTs) are proposed as treatment agent different nanostructure considered to solve mentioned problem. Also, NTs employed treat cancers in dark conditions. The results motivating because NPs do not affect healthy cells, while they strongly viability percentage LNCap reaches 16% for incubation times 48 h. Furthermore, treating using irradiated by NIR beam at 808 nm has no cytotoxicity, cytotoxicity 92% obtained an irradiation 532 nm. applying 635 leads ∼53% (A549 cells). total, have selective effect on greatly reduce given conditions, leading introduction them promising non-invasive moderate candidate therapy.
Язык: Английский
Процитировано
4
Опубликована: Янв. 1, 2025
In this study, the PDT activities of two cationic zinc phthalocyanines, ZnPcs, were investigated in 2D monolayer cultures and 3D spheroids three human cancer cell lines: A253, HT29, FaDu. The results indicate that both molecules are non-toxic absence light, which is a crucial feature an effective photosensitizer. Upon exposure to ZnPc1 exhibited significant cytotoxicity all lines, particularly FaDu cells, spheroids, whereas ZnPc2 showed moderate efficacy compared ZnPc1. using phthalocyanines (Pc) resulted substantial reactive oxygen species (ROS) production. Delayed ROS production higher than immediate ROS, indicating their ability stimulate over extended period retain oxidative stress response cells rather immediately after PDT. Among these molecules, induced delayed more efficiently ZnPc2, consistent with results. These findings confirmed induces ROS-mediated cytotoxic response. mechanisms cellular death triggered by evaluated, revealed apoptosis was predominant process. highlight potential as powerful photosensitizer
Язык: Английский
Процитировано
0
Frontiers in Immunology, Год журнала: 2025, Номер 15
Опубликована: Янв. 8, 2025
Immunologically inert or cold tumors pose a substantial challenge to the effectiveness of immunotherapy. The use oncolytic viruses (OVs) induce immunogenic cell death (ICD) in tumor cells is well-established strategy for initiating cancer immunity cycle (CIC). This process promotes trafficking and infiltration CD8+ T into tumors, thereby eliciting tumor-specific immune response. Despite potential OVs handling clinical outcomes have fallen short expectations. To better understand obstacles faced by virus immunotherapy (OVI), we would like revisit OV issue. Growing evidence indicates that limited intratumoral penetration inadequate distribution are critical factors contributing suboptimal response OVI. Aberrant expressions matrix proteins cancer-associated fibroblasts (CAFs) alter mechanical properties extracellular (ECM). results increased ECM desmoplasia elevated interstitial fluid pressure (IFP), creating physical barriers impede dissemination within tumors. review explores latest advancements strategies designed improve facilitate tumor-infiltrating lymphocytes (TILs) Additionally, investigated current trials challenges associated with translating these practice patient outcomes.
Язык: Английский
Процитировано
0