Journal of Lipid Research, Год журнала: 2024, Номер unknown, С. 100729 - 100729
Опубликована: Дек. 1, 2024
Язык: Английский
Journal of Biophotonics, Год журнала: 2025, Номер unknown
Опубликована: Фев. 19, 2025
ABSTRACT This article gives an overview of the most frequently used fluorescence‐lifetime imaging (FLIM) techniques, their capabilities, and typical applications. Starting from a general introduction to fluorescence phosphorescence lifetime, we will show that lifetime or, more accurately, decay function fluorophore is direct indicator interaction with its molecular environment. FLIM therefore than simple contrast technique in microscopy—it imaging. techniques can be classified into time‐domain frequency‐domain analogue photon counting scanning wide‐field techniques. these technical principles describe features peculiarities different use. An extended section dedicated TCSPC FLIM, addressing unique capabilities make especially interesting biological systems.
Язык: Английский
Процитировано
0
Siberian Journal of Oncology, Год журнала: 2025, Номер 24(1), С. 142 - 149
Опубликована: Март 18, 2025
The aim of the study was to analyze effectiveness experimental and clinical photodynamic therapy combined with chemotherapy in treatment malignant premalignant lesions. Material methods . WoS, Scopus, MedLine, RSCI databases have been searched analyzed on this issue, mainly over past 7 years. We found 288 sources pharmaceutical experimental-clinical studies combination compare therapeutic effects monotherapy, which 50 were included review. Results Photodynamic is a new cancer technology that has become increasingly common recent In some cases, it often an alternative method treating when there high risk side complications during traditional treatments such as surgery, radiation chemotherapy. review summarized current aspects performing Despite fact gives best results neoplasms, strategy limitations. One major challenges very little research conducted field. Additional also needed understand mechanisms increasing therapy. challenge reaching effectively deeper tissues remains significant obstacle wider application Therefore, further determine most effective photosensitizers technologies for using non-ionizing radiation. review, we shown strategies nanopharmaceuticals, demonstrated encouraging results. Conclusion improved efficacy reduced deserve comprehensive study.
Язык: Английский
Процитировано
0
Oncology Reports, Год журнала: 2024, Номер 53(2)
Опубликована: Дек. 30, 2024
Язык: Английский
Процитировано
3
Journal of Photochemistry and Photobiology B Biology, Год журнала: 2024, Номер 259, С. 113007 - 113007
Опубликована: Авг. 8, 2024
Язык: Английский
Процитировано
2
Siberian Journal of Oncology, Год журнала: 2024, Номер 23(4), С. 141 - 151
Опубликована: Сен. 9, 2024
The aim of the study was to present various types radiation that can increase effectiveness combined photodynamic therapy (PDT) for malignant and premalignant lesions. Material Methods . Web Science, Scopus, MedLine, Library, RSCI databases were used finding publications on this topic, mainly over last 10 years. Of 230 sources, 64 included in review. Results Photodynamic is a new cancer treatment technology has become increasingly popular recent It often an alternative method treating when there high risk side effects complications during traditional treatments such as surgery, chemotherapy. PDT requires photosensitizer, light energy, oxygen create reactive species destroy cells. This review examines basic principles mechanisms alone combination with other therapies. Despite fact effective non-invasive treatment, it some limitations, low penetration depth, ineffective photosensitizers tumor hypoxia. Our strategies use energy infrared- x-rays, ultrasound, well electric magnetic fields, enhance effect overcome its limitations. Great hopes are also associated neutron capture (NСT). Currently, chlorin derivatives boron carriers have been developed. They be both fluorescence diagnostics PDT, NСT. synthesized compounds selectivity accumulation tumor. To date, encouraging preclinical results efficiency NСT already obtained. Conclusion Combination sources key factor further development PDT. Future research aimed at overcoming limitations will contribute unlocking full potential clinical practice.
Язык: Английский
Процитировано
1
Photonics Russia, Год журнала: 2024, Номер 18(3), С. 224 - 228
Опубликована: Май 8, 2024
С 23 по 26 апреля 2024 года в Москве прошла Всероссийская конференция с международным участием LUMOS‑2024, посвященная теоретическим и практическим аспектам явления люминесценции (https://lumos‑2024.ru/). Головным организатором мероприятия выступили Химический факультет Факультет наук о материалах МГУ им. М. В. Ломоносова при активном участии Российской академии наук.
Язык: Русский
Процитировано
0
Journal of Biophotonics, Год журнала: 2024, Номер unknown
Опубликована: Окт. 29, 2024
ABSTRACT The effects of cytotoxic chemotherapy on tumor vasculature and oxygenation are in the focus modern investigations because vascular structure distribution oxygen influence behavior treatment response. aim our study was to monitor changes component colorectal xenografts induced by a clinical combination drugs FOLFOX vivo using two complementary techniques: diffuse reflectance spectroscopy (DRS) optical coherence tomography–based microangiography (OCT‐MA). These techniques revealed slower decrease blood treated tumors as compared untreated ones, faster suppression perfusion increase water content result treatment, total hemoglobin tumors. Immunohistochemical analysis hypoxia‐inducible factor HIF‐2α detected tissue hypoxia consequence inappropriate supply obtained results show prospects for monitoring efficacy DRS OCT‐MA.
Язык: Английский
Процитировано
0
Journal of Lipid Research, Год журнала: 2024, Номер unknown, С. 100729 - 100729
Опубликована: Дек. 1, 2024
Язык: Английский
Процитировано
0