Frontiers in Genetics,
Год журнала:
2024,
Номер
15
Опубликована: Дек. 16, 2024
To
understand
the
transcriptomic
profile
of
an
individual
cell
in
a
multicellular
organism,
we
must
comprehend
its
surrounding
environment
and
cellular
space
where
distinct
molecular
stimuli
responses
are
located.
Contradicting
initial
perception
that
RNAs
were
nonfunctional
only
few
could
act
chromatin
remodeling,
over
last
decades,
research
has
revealed
they
multifaceted,
versatile
regulators
most
processes.
Among
various
RNAs,
long
non-coding
(LncRNAs)
regulate
multiple
biological
processes
can
even
impact
fate.
In
this
sense,
subcellular
localization
lncRNAs
is
primary
determinant
their
functions.
It
affects
behavior
by
limiting
potential
partner
which
process
it
affect.
The
fine-tuned
activity
also
tissue-specific
modulated
Biology,
Год журнала:
2024,
Номер
13(8), С. 638 - 638
Опубликована: Авг. 20, 2024
Depression,
a
significant
mental
health
disorder,
is
under
intense
research
scrutiny
to
uncover
its
molecular
foundations.
Epigenetics,
which
focuses
on
controlling
gene
expression
without
altering
DNA
sequences,
offers
promising
avenues
for
innovative
treatment.
This
review
explores
the
pivotal
role
of
epigenetics
in
depression,
emphasizing
two
key
aspects:
(I)
identifying
epigenetic
targets
new
antidepressants
and
(II)
using
personalized
medicine
based
distinct
profiles,
highlighting
potential
focal
points
such
as
methylation,
histone
structure
alterations,
non-coding
RNA
molecules
miRNAs.
Variations
methylation
individuals
with
depression
provide
opportunities
target
genes
that
are
associated
neuroplasticity
synaptic
activity.
Aberrant
acetylation
may
indicate
antidepressant
strategies
involve
enzyme
modifications.
Modulating
miRNA
levels
can
reshape
depression-linked
expression.
The
second
section
discusses
profiles.
Analyzing
these
patterns
could
identify
biomarkers
treatment
response
susceptibility
facilitating
tailored
treatments
proactive
care.
Addressing
ethical
concerns
regarding
information,
privacy
stigmatization,
crucial
understanding
biological
basis
depression.
Therefore,
researchers
must
consider
issues
when
examining
disorders.
importance
critical
aspect
modern
medical
research.
These
findings
hold
great
novel
medications
treatments,
would
significantly
improve
patient
outcomes,
transform
psychiatry.
As
progresses,
it
expected
more
complex
aspects
processes
enhance
our
comprehension,
increase
effectiveness
therapies.
The Journal of Physical Chemistry Letters,
Год журнала:
2025,
Номер
unknown, С. 1702 - 1708
Опубликована: Фев. 10, 2025
Predicting
the
binding
poses
of
ligands
targeting
RNAs
is
challenging.
Here,
we
propose
that
using
first-principles
quantum
mechanics/molecular
mechanics
(QM/MM)
simulations,
which
incorporate
automatically
polarization
effects,
can
help
refine
structural
determinants
ligand/RNA
complexes
in
aqueous
solution.
In
fact,
recent
advances
massively
parallel
computer
architectures
(such
as
exascale
machines),
combined
with
power
machine
learning,
are
greatly
expanding
domain
applicability
these
types
notoriously
expensive
simulations.
We
corroborate
this
proposal
by
carrying
out
a
QM/MM-based
study
on
ligand
CAG
repeat-RNA,
involved
Huntington's
disease.
The
calculations
indeed
show
clear
improvement
properties,
and
they
consistent
NMR
measurements,
also
performed
here.
Thus,
type
approach
may
be
useful
for
practical
applications
design
RNA
near
future.
Cellular and Molecular Neurobiology,
Год журнала:
2025,
Номер
45(1)
Опубликована: Март 8, 2025
CNS
diseases
account
for
a
major
part
of
the
comorbidity
and
mortality
human
population;
moreover,
neuroinflammation
has
become
an
indication
different
diseases,
instance,
Parkinson's
Alzheimer's
disease.
Microglia
astrocytes
are
two
main
glial
cells
that
can
be
found
in
CNS.
Each
these
plays
important
role
mediating
immune
responses
like
inflammation.
There
many
studies
suggesting
LncRNAs
neuroinflammation.
Indeed,
orchestrate
through
various
mechanisms,
namely
miRNA
sponge,
transcriptional
activation/inhibition.
In
addition,
regulate
downstream
pathways
NF-κB,
PI3K/AKT.
this
study,
we
gathered
existing
regarding
mechanisms
action
pathogenesis
neurodegenerative
traumatic
injuries
regulating
We
aim
to
elaborate
on
regulatory
roles
bring
more
profound
understanding
etiology
terms
Journal of Toxicology and Environmental Health,
Год журнала:
2025,
Номер
unknown, С. 1 - 9
Опубликована: Март 5, 2025
Alzheimer
's
disease,
a
neurodegenerative
is
considered
serious
global
type
of
dementia
affecting
predominantly
elderly
associated
with
progressive
memory
loss.
disease
exhibits
typical
pathological
manifestations
including
neuronal
loss,
β-amyloid
deposition,
and
tau
protein
neurofibrillary
tangles.
Significantly
increased
expression
long-non
-coding
transcript
RNA,
LncRNA
SNHG1,
was
detected
in
the
brain
AD
patients.
However,
it
not
clear
whether
knockdown
SNHG1
might
improve
autophagy
function
SH-SY5Y
cells
reduce
number
apoptotic
cells.
The
aim
this
study
to
(1)
examine
role
on
autophagic
following
induction
by
Aβ1-42
(2)
elucidate
underlying
mechanisms.
were
transfected
lentiviral
vectors
construct
cell
line
stable
genetic
ability
knock
down
compared
control
empty
vector
line.
Following
for
24
hr,
an
model
constructed.
Downregulation
significantly
viability
lowered
Concomitantly
downregulation
induced
significant
decrease
p-tau
caspase3
elevated
Beclin1
AMBRA1.
Our
results
showed
that
reduced
enhancing
Data
suggest
knocking
may
be
potential
target
compounds
treat
AD.
Neurobiology of Disease,
Год журнала:
2025,
Номер
unknown, С. 106867 - 106867
Опубликована: Март 1, 2025
Behavioral
variant
of
Frontotemporal
Dementia
(bvFTD)
and
Bipolar
Disorder
(BD)
share
overlapping
symptoms,
complicating
diagnosis.
BvFTD,
especially
linked
to
C9orf72
expansions,
often
mimics
BD,
highlighting
the
need
for
reliable
biomarkers.
This
study
aimed
differentiate
bvFTD
from
BD
using
miRNA
profiles
in
neural-enriched
extracellular
vesicles
(NEVs).
A
cohort
100
subjects
was
analyzed:
40
(20
sporadic,
20
carriers),
healthy
controls.
NEVs
were
isolated
plasma
profiled
real-time
PCR.
Among
754
miRNAs,
11
significantly
deregulated
BD.
MiR-152-5p
downregulated
sporadic
bvFTD,
while
let-7b,
let-7e,
miR-18b,
miR-142-5p
altered
carriers.
patients
showed
distinct
patterns
miR-331-5p,
miR-335,
miR-345
compared
bvFTD.
Bioinformatics
analyses
revealed
that
common
long
non-coding
RNA
(lncRNA)
targets,
including
XIST,
NEAT1,
OIP5-AS1,
suggesting
their
involvement
molecular
networks
relevant
C9orf72-related
These
signatures
can
cases,
offer
insights
into
disease
pathways.
Further
research
is
needed
validate
these
findings
explore
clinical
application.
Abstract
Multiple
sclerosis
(MS)
and
Neuromyelitis
Optica
(NMO)
are
immune-related
CNS
inflammatory
diseases
that
often
present
with
overlapping
clinical
symptoms,
leading
to
frequent
misdiagnosis,
particularly
in
aquaporin-4
seronegative
NMO
patients.
Identifying
the
underlying
mechanisms
of
these
is
critical
for
discovering
biomarkers
enable
timely
diagnosis
effective
treatment.
This
study
included
252
participants,
divided
into
four
groups.
Group
I
(Relapsing–Remitting
MS:
RRMS
group),
II
(Secondary
Progressive
SPMS
III
(NMO
IV
(Healthy
controls).
Blood
samples
were
collected
from
all
participants
measure
expression
levels
Neuregulin-1
(NRG1),
lncRNA
Ftx,
miR-382-5p
.
The
results
showed
NRG1
significantly
lower
RRMS,
SPMS,
groups
compared
healthy
controls,
most
pronounced
reduction
observed
NMO,
suggesting
may
serve
as
a
potential
biomarker
differentiating
MS,
especially
cases
where
traditional
diagnostic
criteria
inconclusive.
Ftx
,
sponge
exhibited
an
opposite
trend
was
downregulated
its
promising
biomarker.
Our
findings
highlight
NRG1,
diagnostic,
screening,
prognostic
biomarkers,
well
tools
differential
MS.
Graphical
Brain Sciences,
Год журнала:
2024,
Номер
14(8), С. 818 - 818
Опубликована: Авг. 15, 2024
Neurodegeneration
occurs
naturally
as
humans
age,
but
the
presence
of
additional
pathogenic
mechanisms
yields
harmful
and
consequential
effects
on
brain.
Alzheimer's
disease
(AD),
most
common
form
dementia,
is
a
composite
such
factors.
Despite
extensive
research
to
identify
exact
causes
AD,
therapeutic
approaches
for
treating
continue
be
ineffective,
indicating
important
gaps
in
our
understanding
mechanisms.
Long
non-coding
RNAs
(lncRNAs)
are
an
endogenous
class
regulatory
RNA
transcripts
longer
than
200
nucleotides,
involved
various
networks,
whose
dysregulation
evident
several
neural
extraneural
diseases.
LncRNAs
ubiquitously
expressed
across
all
tissues
with
wide
range
functions,
including
controlling
cell
differentiation
development,
responding
environmental
stimuli,
other
physiological
processes.
Several
lncRNAs
have
been
identified
potential
contributors
worsening
neurodegeneration
due
altered
regulation
during
abnormal
pathological
conditions.
Within
neurological
disease,
prime
candidates
use
biomarkers
pharmacological
targets.
Gender-associated
lncRNA
expression
gender-dependent
manner
suggesting
more
needs
focused
this
relationship.
Overall,
their
connection
neurodegenerative
growing
exponentially,
commercial
enterprises
already
designing
employing
therapeutics.
In
review
we
offer
comprehensive
overview
current
state
knowledge
role
AD
discuss
implications
targets
diagnostic
patients
disease.
