Stimulation of endothelin-1 production by autoantibodies present in patients with scleroderma renal crisis
Clinical Immunology,
Год журнала:
2025,
Номер
unknown, С. 110454 - 110454
Опубликована: Фев. 1, 2025
Here,
we
investigate
how
autoantibodies
against
G
protein-coupled
receptors
(GPCRs)
on
endothelial
cells,
which
are
present
in
patients
with
scleroderma
renal
crisis
(SRC)
impact
endothelin-1
(ET-1)
production
human
microvascular
cells
(HMECs).
To
this
end,
serum
IgG
fraction
was
isolated
from
SRC
and
applied
to
HMECs
culture.
Compared
treated
either
plain
control
medium
or
healthy
individuals,
exposure
of
SRC-IgG
resulted
a
time-
concentration-dependent
increase
ET-1
expression
release.
This
effect
could
be
blocked
by
the
protease
activated
receptor
1
(PAR1)
inhibitor
mimicked
thrombin,
PAR1
activator.
Transcription
factor
C-FOS/AP-1
tissue
(TF)
were
identified
as
mediators
these
responses.
Thus,
it
can
concluded
that
stimulates
produce
ET-1,
acting
through
cooperation
TF.
Язык: Английский
Autoantibodies in COVID‐19 and Other Viral Diseases: Molecular, Cellular, and Clinical Perspectives
Reviews in Medical Virology,
Год журнала:
2024,
Номер
34(5)
Опубликована: Сен. 1, 2024
ABSTRACT
Autoantibodies
are
immune
system‐produced
antibodies
that
wrongly
target
the
body's
cells
and
tissues
for
attack.
The
COVID‐19
pandemic
has
made
it
possible
to
link
autoantibodies
both
severity
of
pathogenic
infection
emergence
several
autoimmune
diseases
after
recovery
from
infection.
An
overview
disorders
function
in
other
infectious
discussed
this
review
article.
We
also
investigated
different
categories
found
including
potential
pathways
by
which
they
contribute
illness.
Additionally,
highlights
probable
connection
between
vaccine‐induced
their
adverse
outcomes.
discusses
therapeutic
perspectives
autoantibodies.
This
paper
advances
our
knowledge
about
intricate
interaction
thoroughly
assessing
most
recent
findings.
Язык: Английский
Autoantibodies as putative biomarkers and triggers of cell dysfunctions in systemic sclerosis
Current Opinion in Rheumatology,
Год журнала:
2024,
Номер
37(1), С. 51 - 63
Опубликована: Июль 24, 2024
Antinuclear
autoantibodies
represent
a
serological
hallmark
of
systemic
sclerosis
(SSc),
with
anticentromere,
antitopoisomerase-I,
and
anti-RNA
polymerase
III
antibodies
routinely
assessed
for
diagnosis,
clinical
subset
classification,
prognosis.
In
addition,
an
increasing
number
have
been
demonstrated
to
play
pathogenic
role
by
mediating
different
SSc
manifestations.
This
review
aims
give
overview
on
as
putative
biomarkers
in
discuss
their
possible
triggers
cell
dysfunctions.
Язык: Английский