Polyphenols, Alkaloids, and Terpenoids Against Neurodegeneration: Evaluating the Neuroprotective Effects of Phytocompounds Through a Comprehensive Review of the Current Evidence
Metabolites,
Год журнала:
2025,
Номер
15(2), С. 124 - 124
Опубликована: Фев. 13, 2025
Neurodegenerative
diseases
comprise
a
group
of
chronic,
usually
age-related,
disorders
characterized
by
progressive
neuronal
loss,
deformation
structure,
or
loss
function,
leading
to
substantially
reduced
quality
life.
They
remain
significant
focus
scientific
and
clinical
interest
due
their
increasing
medical
social
importance.
Most
neurodegenerative
present
intracellular
protein
aggregation
extracellular
deposition
(plaques),
such
as
α-synuclein
in
Parkinson's
disease
amyloid
beta
(Aβ)/tau
aggregates
Alzheimer's.
Conventional
treatments
for
conditions
incur
high
costs
are
related
the
development
several
adverse
effects.
In
addition,
many
patients
irresponsive
them.
For
these
reasons,
there
is
growing
tendency
find
new
therapeutic
approaches
help
patients.
This
review
intends
investigate
some
phytocompounds'
effects
on
diseases.
These
generally
increased
oxidative
stress
inflammation,
so
phytocompounds
can
prevent
treat
To
achieve
our
aim
provide
critical
assessment
current
literature
about
phytochemicals
targeting
neurodegeneration,
we
reviewed
reputable
databases,
including
PubMed,
EMBASE,
COCHRANE,
seeking
trials
that
utilized
against
conditions.
A
few
investigated
humans,
after
screening,
13
were
ultimately
included
following
PRISMA
guidelines.
compounds
include
polyphenols
(flavonoids
luteolin
quercetin,
phenolic
acids
rosmarinic
acid,
ferulic
caffeic
other
like
resveratrol),
alkaloids
(such
berberine,
huperzine
A,
caffeine),
terpenoids
ginkgolides
limonene).
The
gathered
evidence
underscores
caffeine,
ginkgolides,
primarily
anti-inflammatory,
antioxidant,
neuroprotective,
counteracting
neuroinflammation,
oxidation,
synaptic
dysfunctions,
which
crucial
aspects
intervention
various
conditions,
Alzheimer's
dementias,
depression,
neuropsychiatric
disorders.
summary,
they
show
use
improvements
cognition,
memory,
disinhibition,
irritability/lability,
aberrant
behavior,
hallucinations,
mood
Язык: Английский
Curcumin Solubility and Bioactivity Enhancement Through Amorphization with Tryptophan via Supercritical Fluid Technology
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(2), С. 855 - 855
Опубликована: Янв. 20, 2025
Curcumin,
a
compound
known
for
its
antioxidant
and
neuroprotective
properties,
faces
challenges
due
to
low
water
solubility,
which
can
limit
effectiveness.
One
effective
method
address
this
issue
is
through
amorphization.
Incorporating
curcumin
into
polymeric
matrix
form
amorphous
solid
dispersions
common
approach.
Another
strategy
involves
co-amorphous
systems,
where
low-molecular-weight
components
act
as
co-formers.
A
recent
innovative
approach
combines
these
strategies.
This
study
used
tryptophan
co-former
prepared
systems
using
supercritical
fluid
technology.
The
nature
of
two
was
confirmed
X-ray
powder
diffraction:
one
with
10%
polymer,
another
curcumin,
tryptophan.
Fourier-transform
infrared
analysis
demonstrated
molecular
interactions
among
all
in
the
systems.
Scanning
electron
microscopy
revealed
that
amorphization
process
significantly
modified
morphology
particles.
ternary
system
notably
increased
solubility
by
over
300-fold.
both
exhibited
higher
dissolution
rates
compared
crystalline
form.
showed
more
than
threefold
improvement
permeability
according
PAMPA
test.
enhanced
led
sixfold
increase
activity
25-fold
inhibition
enzyme
butyrylcholinesterase.
Язык: Английский
Mechanochemical Approach to Obtaining a Multicomponent Fisetin Delivery System Improving Its Solubility and Biological Activity
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(7), С. 3648 - 3648
Опубликована: Март 25, 2024
In
this
study,
binary
amorphous
solid
dispersions
(ASDs,
fisetin-Eudragit®)
and
ternary
inclusions
(ASIs,
fisetin-Eudragit®-HP-β-cyclodextrin)
of
fisetin
(FIS)
were
prepared
by
the
mechanochemical
method
without
solvent.
The
nature
FIS
in
ASDs
ASIs
was
confirmed
using
XRPD
(X-ray
powder
diffraction).
DSC
(Differential
scanning
calorimetry)
full
miscibility
multicomponent
delivery
systems.
FT-IR
(Fourier-transform
infrared
analysis)
interactions
that
stabilize
FIS's
state
identified
functional
groups
involved.
study
culminated
evaluating
impact
amorphization
on
water
solubility
conducting
vitro
antioxidant
assays:
2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic
acid)-ABTS,
2,2-diphenyl-1-picrylhydrazyl-DPPH,
Cupric
Reducing
Antioxidant
Capacity-CUPRAC,
Ferric
Power-FRAP
neuroprotective
inhibition
acetylcholinesterase-AChE
butyrylcholinesterase-BChE.
addition,
molecular
docking
allowed
for
determination
possible
bonds
between
mentioned
above
enzymes.
best
preparation
turned
out
to
be
ASI_30_EPO
(ASD
fisetin-Eudragit®
containing
30%
combination
with
HP-β-cyclodextrin),
which
showed
an
improvement
apparent
(126.5
±
0.1
µg∙mL-1)
properties
(ABTS:
IC50
=
10.25
µg∙mL-1,
DPPH:
27.69
CUPRAC:
IC0.5
9.52
FRAP:
8.56
(inhibition
AChE:
39.91%,
BChE:
42.62%).
Язык: Английский
Prebiotic Systems Containing Anthocyanin-Rich Pomegranate Flower Extracts with Antioxidant and Antidiabetic Effects
Pharmaceutics,
Год журнала:
2024,
Номер
16(4), С. 526 - 526
Опубликована: Апрель 10, 2024
Pomegranate
flower
extract,
rich
in
anthocyanins,
demonstrates
beneficial
health-promoting
properties
such
as
an
anti-diabetic
and
antioxidant
effect,
among
others.
However,
the
potential
may
be
hindered
by
low
stability
of
anthocyanins.
Therefore,
aim
our
study
was
to
assess
whether
stabilizing
carriers,
namely
HP-γ-cyclodextrin
(HP-γ-CD),
α-cyclodextrin
(α-CD),
Methyl-β-cyclodextrin
(Me-β-CD),
Inulin
(Inu)
Arabic
gum
(AGu)
affect
antidiabetic
activity
lyophilized
pomegranate
how
they
influence
stability,
release
profile,
systems
exhibit
prebiotic
activity.
Interactions
between
extract
these
factors
were
analyzed
using
FT-IR.
The
structures
examined
through
microscopic
imaging
while
for
prepared
systems,
determined
confirmed
inhibition
α-amylase
α-glucosidase;
expressed
DPPH
CUPRAC
assays.
content
pelargonidin-3,5-glucoside
assessed
HPLC
method.
profiles
a
medium
at
pH
=
6.8
1.2,
after
subjecting
high
temperatures
(T
90
°C).
evaluated
10
bacterial
strains
(Lactobacillus
acidophilus,
Lactobacillus
casei,
plantarum,
brevis
rhamnosus
gg,
reuteri,
Pediococcus
pentosaceus,
Lactococcus
lactis,
fermentum
lf,
Streptococcus
thermophilus).
As
result
conducted
research,
better
functionalities
obtained
containing
proven
terms
effects.
delivery
allow
use
its
Язык: Английский
Enhancing the Solubility and Dissolution of Apigenin: Solid Dispersions Approach
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(2), С. 566 - 566
Опубликована: Янв. 10, 2025
Apigenin
(APG),
a
bioactive
flavonoid
with
promising
therapeutic
potential,
suffers
from
poor
water
solubility,
which
limits
its
bioavailability.
To
address
this,
solid
dispersions
of
APG
were
prepared
using
ball
milling
sodium
alginate
(SA),
Pluronic®
F-68
(PLU68),
F-127
(PLU127),
PVP
K30,
and
VA64
as
polymeric
excipients.
These
screened
for
apparent
solubility
in
buffers
pH
1.2,
5.5,
6.8.
Based
on
improved
after
60
min,
APG-PLU68
APG-PLU127
selected
further
study.
DSC
FT-IR
analysis
confirmed
molecular
interactions
between
the
polymer
matrices,
contributing
to
enhanced
dissolution
rates.
Dissolution
rate
studies
showed
that
achieved
100%
at
6.8,
suggesting
potential
use
environments
such
small
intestine.
Additionally,
exhibited
84.3%
indicating
oral
dosage
forms,
where
could
be
absorbed
acidic
conditions
stomach.
The
stability
study
storage
one
year
under
ambient
does
not
cause
chemical
degradation
but
affects
physical
state
dispersion.
Antioxidant
activity
was
assessed
ABTS
assay.
Freshly
obtained
68.1%
±
1.94%
activity,
whereas
stored
66.2%
1.62%
(significant
difference,
p
<
0.05).
difference
related
slight
decrease
dispersion
(T0
=
252
1
μg∙mL-1,
T1
246
μg∙mL-1).
findings
demonstrate
superior
performance
PLU127
carrier
enhancing
release,
antioxidant
APG.
Язык: Английский
The Interplay Between Autophagy and Apoptosis in the Mechanisms of Action of Stilbenes in Cancer Cells
Antioxidants,
Год журнала:
2025,
Номер
14(3), С. 339 - 339
Опубликована: Март 13, 2025
Plant-based
stilbenes
are
low-molecular-weight
polyphenolic
compounds
that
exhibit
anti-oxidant,
anti-microbial,
anti-fungal,
anti-inflammatory,
anti-diabetic,
cardioprotective,
neuroprotective,
and
anti-cancer
activities.
They
phytoalexins
produced
in
diverse
plant
species
response
to
stress,
such
as
fungal
bacterial
infections
or
excessive
UV
irradiation.
Plant-derived
dietary
products
containing
common
components
of
the
human
diet.
Stilbenes
appear
be
promising
chemopreventive
chemotherapeutic
agents.
Accumulating
evidence
indicates
able
trigger
both
apoptotic
autophagic
molecular
pathways
many
cancer
cell
lines.
Of
note,
crosstalk
between
autophagy
apoptosis
under
cellular
stress
conditions
determines
fate.
The
relationship
is
complex
depends
on
context,
e.g.,
type
level.
Apoptosis
a
regulated
death,
whereas
may
act
pro-survival
pro-death
mechanism
depending
context.
interplay
have
an
important
impact
chemotherapy
efficiency.
This
review
focuses
vitro
effects
different
lines
concerning
apoptosis.
Язык: Английский