The Effects of Fisetin and Curcumin on Oxidative Damage Caused by Transition Metals in Neurodegenerative Diseases
Molecular Neurobiology,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 6, 2024
Язык: Английский
Enhancing the Solubility and Dissolution of Apigenin: Solid Dispersions Approach
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(2), С. 566 - 566
Опубликована: Янв. 10, 2025
Apigenin
(APG),
a
bioactive
flavonoid
with
promising
therapeutic
potential,
suffers
from
poor
water
solubility,
which
limits
its
bioavailability.
To
address
this,
solid
dispersions
of
APG
were
prepared
using
ball
milling
sodium
alginate
(SA),
Pluronic®
F-68
(PLU68),
F-127
(PLU127),
PVP
K30,
and
VA64
as
polymeric
excipients.
These
screened
for
apparent
solubility
in
buffers
pH
1.2,
5.5,
6.8.
Based
on
improved
after
60
min,
APG-PLU68
APG-PLU127
selected
further
study.
DSC
FT-IR
analysis
confirmed
molecular
interactions
between
the
polymer
matrices,
contributing
to
enhanced
dissolution
rates.
Dissolution
rate
studies
showed
that
achieved
100%
at
6.8,
suggesting
potential
use
environments
such
small
intestine.
Additionally,
exhibited
84.3%
indicating
oral
dosage
forms,
where
could
be
absorbed
acidic
conditions
stomach.
The
stability
study
storage
one
year
under
ambient
does
not
cause
chemical
degradation
but
affects
physical
state
dispersion.
Antioxidant
activity
was
assessed
ABTS
assay.
Freshly
obtained
68.1%
±
1.94%
activity,
whereas
stored
66.2%
1.62%
(significant
difference,
p
<
0.05).
difference
related
slight
decrease
dispersion
(T0
=
252
1
μg∙mL-1,
T1
246
μg∙mL-1).
findings
demonstrate
superior
performance
PLU127
carrier
enhancing
release,
antioxidant
APG.
Язык: Английский
Novel Supramolecular Nanoparticles Modified with Phosphatidylcholine Improve the Bioavailability of Fisetin and Alleviate Alcoholism through Antioxidant and Antiinflammatory Effects
ACS Applied Nano Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 11, 2024
Язык: Английский
Amorphous solid dispersion to facilitate the delivery of poorly water-soluble drugs: recent advances on novel preparation processes and technology coupling
Expert Opinion on Drug Delivery,
Год журнала:
2024,
Номер
unknown, С. 1 - 16
Опубликована: Ноя. 1, 2024
Introduction
Amorphous
solid
dispersion
(ASD)
technique
has
recently
been
used
as
an
effective
formulation
strategy
to
significantly
improve
the
bioavailability
of
insoluble
drugs.
The
main
industrialized
preparation
methods
for
ASDs
are
mainly
hot
melt
extrusion
and
spray
drying
techniques;
however,
they
face
limitations
being
unsuitable
heat-sensitive
materials
organic
reagent
residues,
respectively,
therefore
novel
processes
technology
coupling
developing
have
received
increasing
attention.
Язык: Английский