Pharmaceuticals,
Год журнала:
2024,
Номер
17(12), С. 1596 - 1596
Опубликована: Ноя. 27, 2024
Background:
Curcuminoids,
the
bioactive
compounds
found
in
turmeric,
exhibit
potent
antioxidant,
anti-inflammatory,
and
neuroprotective
properties.
This
study
aims
to
enhance
extraction
of
curcuminoids
from
turmeric
using
environmentally
friendly
solvents
supercritical
CO2
(scCO2)
combined
with
natural
deep
eutectic
(NADESs)
one
process,
evaluate
resulting
biological
activity.
Methods:
A
Box–Behnken
statistical
design
was
applied
optimize
scCO2
conditions—pressure,
volume,
temperature—to
maximize
curcuminoid
yield.
Next,
menthol
lactic
acid
NADESs
were
selected,
these
two
into
a
single
process.
The
activity
extract
evaluated
antioxidant
assays
(ferric
reducing
power
2,2-diphenyl-1-picrylhydrazyl)
enzyme
inhibition
(acetylcholinesterase,
butyrylcholinesterase,
tyrosinase).
Toxicity
assessments
conducted
on
aquatic
invertebrates
Daphnia
pulex,
Artemia
sp.,
Chironomus
aprilinus.
Results:
most
effective
achieved
menthol–lactic
NADES
as
cosolvent,
integrated
at
1:20
ratio
plant
material
while
combination
scCO2.
optimized
scCO2–NADES
resulted
high
yield
(33.35
mg/g),
outperforming
(234.3
μg/g),
ultrasound-assisted
(30.50
alcohol-based
(22.95–26.42
mg/g).
In
assays,
demonstrated
significant
enzymes
studies
showed
concentration-dependent
response,
EC50
for
aprilinus
level
0.098
μL/mL
pulex
exhibiting
sensitivity
extract.
Conclusions:
highlights
potential
combining
demonstrating
effectiveness
maximizing
enhancing
bioactivity.
PLoS ONE,
Год журнала:
2024,
Номер
19(5), С. e0303556 - e0303556
Опубликована: Май 16, 2024
Echinatin
is
an
active
ingredient
in
licorice,
a
traditional
Chinese
medicine
used
the
treatment
of
inflammatory
disorders.
However,
protective
effect
and
underlying
mechanism
echinatin
against
acute
lung
injury
(ALI)
still
unclear.
Herein,
we
aimed
to
explore
echinatin-mediated
anti-inflammatory
effects
on
lipopolysaccharide
(LPS)-stimulated
ALI
its
molecular
mechanisms
macrophages.
In
vitro
,
markedly
decreased
levels
nitric
oxide
(NO)
prostaglandin
E2
(PGE
2
)
LPS-stimulated
murine
MH-S
alveolar
macrophages
RAW264.7
by
suppressing
inducible
synthase
cyclooxygenase-2
(COX-2)
expression.
Furthermore,
reduced
LPS-induced
mRNA
expression
release
interleukin-1β
(IL-1β)
IL-6
cells.
Western
blotting
CETSA
showed
that
repressed
activation
mitogen-activated
protein
kinase
(MAPK)
nuclear
factor-kappa
B
(NF-κB)
pathways
through
targeting
transforming
growth
factor-beta-activated
1
(TAK1).
directly
interacted
with
Kelch-like
ECH-associated
(Keap1)
activated
factor
erythroid
2-related
(Nrf2)
pathway
enhance
heme
oxygenase-1
(HO-1)
vivo
ameliorated
injury,
production
IL-1β
IL-6.
These
findings
demonstrated
exerted
via
blocking
TAK1-MAPK/NF-κB
activating
Keap1-Nrf2-HO-1
pathway.
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Март 20, 2025
To
investigate
the
effects
of
nano
selenium
(nano-Se),
curcumin
(CUR),
and
glycyrrhiza
extracts
(GE)
on
reproductive
performance,
antioxidant
immune
functions
primiparous
sows
parity-2
sows,
54
(Landrace
×
Yorkshire)
were
randomly
divided
into
three
groups
(18
per
group):
(1)
CON
group,
basal
diet
(0.30
mg·kg−1
Se,
sodium
selenite);
(2)
CUR
+
0.20
Se
(nano-Se)
300
CUR;
(3)
GE
500
GE.
The
trial
lasted
for
approximately
180
days
from
day
90
gestation
to
sows.
There
no
significant
differences
in
performance
among
(p
>
0.05),
but
litter
weight
gain
piglets
group
was
16.49%
higher
than
that
<
0.05).
Compared
with
serum
SOD
GSH-Px
levels
significantly
increased,
MDA
content
extremely
decreased.
concentrations
IL-6
IL-1β
0.05)
lower
those
IL-10
TNF-α
higher.
combination
nano-Se
decreased
level
increased
concentration
In
conclusion,
addition
along
or
at
parturition,
enhanced
their
stress
resistance,
thus
improved
growth
offspring
Kazan medical journal,
Год журнала:
2024,
Номер
105(5), С. 813 - 824
Опубликована: Окт. 2, 2024
The
review
summarized
the
literature
data
of
recent
years
on
antitumor
effect
secondary
plant
metabolites,
as
well
their
immunotropic
and
anti-inflammatory
effects
components
response.
biological
basis
for
action
metabolites
was
characterized
in
form
influence
potential
targets:
transcription
factors,
signaling
pathways
receptors
responsible
proliferation
apoptosis.
ways
increasing
bioavailability
to
enhance
effectiveness
possibility
medicinal
use
were
considered,
berberine,
curcumin
derivatives
described.
search
scientific
publications
conducted
foreign
(PubMed)
domestic
(eLibrary)
electronic
libraries.
It
found
that
multiplicity
molecular
targets
pleiotropy
suggest
regulation
various
processes
tumor
normal
cells.
There
a
connection
between
immunomodulatory
action.
However,
significant
limitation
fact
most
studies
cell
cultures,
which
insufficient
judge
effect.
Clinical
trials
few
results
contradictory.
In
addition,
certain
contradiction
has
been
noted
idea
more
effective
when
using
pure
substance
or
complex
composition
components.
An
important
problem
low
methods
have
proposed.
Despite
long
history
phytotherapy
oncology,
development
new
with
high
water
solubility
remains
relevant,
including
modified
molecules
known
ones
unexplored
activity.
Modern
chemical
synthesis
delivery
systems
study
model
experiments,
seem
be
promising
directions
creation
drugs
Pharmaceuticals,
Год журнала:
2024,
Номер
17(12), С. 1674 - 1674
Опубликована: Дек. 11, 2024
Herbal
medicine,
particularly
in
developing
regions,
remains
highly
popular
due
to
its
cost-effectiveness,
accessibility,
and
minimal
risk
of
adverse
effects.
Curcuma
longa
L.,
commonly
known
as
turmeric,
exemplifies
such
herbal
remedies
with
extensive
history
culinary
medicinal
applications
across
Asia
for
thousands
years.
Traditionally
utilized
a
dye,
flavoring,
cultural
rituals,
turmeric
has
also
been
employed
treat
spectrum
medical
conditions,
including
inflammatory,
bacterial,
fungal
infections,
jaundice,
tumors,
ulcers.
Building
on
this
longstanding
use,
contemporary
biochemical
clinical
research
identified
curcumin—the
primary
active
compound
turmeric—as
possessing
significant
therapeutic
potential.
This
review
hypothesizes
that
curcumin’s
antioxidant
properties
are
pivotal
preventing
treating
chronic
inflammatory
diseases,
which
often
precursors
more
severe
cancer,
neurological
disorders,
like
Parkinson’s
Alzheimer’s
disease.
Additionally,
while
curcumin
demonstrates
favorable
safety
profile,
anticoagulant
effects
warrant
cautious
application.
article
synthesizes
recent
studies
elucidate
the
molecular
mechanisms
underlying
actions
evaluates
efficacy
various
human
illnesses,
bowel
disease,
osteoarthritis,
atherosclerosis,
peptic
ulcers,
COVID-19,
psoriasis,
vitiligo,
depression.
By
integrating
diverse
findings,
aims
provide
comprehensive
perspective
role
modern
medicine
potential
multifaceted
agent.
Pharmaceuticals,
Год журнала:
2024,
Номер
17(11), С. 1489 - 1489
Опубликована: Ноя. 6, 2024
Depression
is
one
of
the
most
common
diseases
in
world,
and
it
also
mental
disorder.
Depressive
disorders
are
a
real
threat
not
only
to
individuals,
but
general
population.
This
disease
leading
cause
disability
inability
work.
Due
numerous
side
effects
conventional
drugs,
attention
increasingly
being
paid
other
solutions,
including
herbal
medicines.
Many
plant
species
known
for
their
traditional
uses
treatment
anxiety,
insomnia,
depression.
The
clinically
proven
adaptogenic
raw
materials
on
depression
symptoms
probably
related
positive
impact
some
secondary
metabolites
(terpenoids,
alkaloids,
glucosinolates,
phenols).
Currently,
emphasized
that
many
cases
antioxidant
anti-inflammatory
properties
substances
play
protective
role
at
neurocellular
level.
Among
medicinal
plants
analyzed
clinical
trials
depression,
following
seem
be
particularly
interesting:
saffron
(Crocus
L.),
turmeric
(Curcuma
ginkgo
(Ginkgo
St.
John's
wort
(Hypericum
passionflower
(Passiflora
which
have
broad
strong
biological
activity,
well-documented
history
action
use,
effectiveness
preventing
and/or
treating
anxiety
These
still
sphere
biochemical
phytopharmaceutical
research,
results
very
promising.
