Health and Ecology Issues,
Год журнала:
2025,
Номер
21(4), С. 37 - 44
Опубликована: Янв. 16, 2025
Objective
.
To
determine
and
establish
the
unity
of
some
indices
antioxidant
status
before
treatment
patients
with
liver
cirrhosis
acute
blood
loss.
Materials
methods
The
present
study
included
267
loss
varying
severity,
as
well
20
practically
healthy
volunteers.
On
day
admission
to
hospital,
for
key
indicators
system:
nitrate
(NO
3
-
)
nitrite
ions
2
),
superoxide
dismutase
(SOD),
catalase
(Cat)
glutathione
reductase
(GR)
was
collected
from
treatment.
Results
Depending
on
severity
loss,
showed
a
decrease
in
concentration
NO
,
SOD,
Cat,
increase
GR,
which
is
redox
adaptation,
indicates
development
oxidative
stress
its
manifestations:
multiorgan
failure
syndrome.
Conclusion
Interpretation
formative
well-being
criteria:
Cat
GR
indicator
complex
assessment
extent
pathophysiological
reactions
initiation
Pharmaceuticals,
Год журнала:
2024,
Номер
17(8), С. 975 - 975
Опубликована: Июль 23, 2024
Oxidative
stress,
driven
by
reactive
oxygen,
nitrogen,
and
sulphur
species
(ROS,
RNS,
RSS),
poses
a
significant
threat
to
cellular
integrity
human
health.
Generated
during
mitochondrial
respiration,
inflammation,
UV
exposure
pollution,
these
damage
cells
contribute
pathologies
like
cardiovascular
issues,
neurodegeneration,
cancer,
metabolic
syndromes.
Lifestyle
factors
exert
substantial
influence
on
oxidative
stress
levels,
with
mitochondria
emerging
as
pivotal
players
in
ROS
generation
equilibrium.
Phytochemicals,
abundant
plants,
such
carotenoids,
ascorbic
acid,
tocopherols
polyphenols,
offer
diverse
antioxidant
mechanisms.
They
scavenge
free
radicals,
chelate
metal
ions,
modulate
signalling
pathways
mitigate
damage.
Furthermore,
plants
thriving
high-altitude
regions
are
adapted
extreme
conditions,
synthesize
secondary
metabolites,
flavonoids
phenolic
compounds
bulk
quantities,
which
act
form
robust
defence
against
including
radiation
temperature
fluctuations.
These
promising
sources
for
drug
development,
offering
innovative
strategies
manage
stress-related
ailments
enhance
Understanding
harnessing
the
potential
of
phytochemicals
from
represent
crucial
steps
combating
stress-induced
disorders
promoting
overall
wellbeing.
This
study
offers
comprehensive
summary
production
physio-pathological
aspects
lifestyle-induced
explores
antioxidants.
Additionally,
it
presents
an
appraisal
medicinal
antioxidants,
highlighting
their
development
creation
therapeutic
approaches.
Foods,
Год журнала:
2024,
Номер
13(23), С. 3886 - 3886
Опубликована: Дек. 1, 2024
Foodborne
pathogens
are
microorganisms
that
cause
illness
through
contamination,
presenting
significant
risks
to
public
health
and
food
safety.
This
review
explores
the
metabolites
produced
by
these
pathogens,
including
toxins
secondary
metabolites,
their
implications
for
human
health,
particularly
concerning
cancer
risk.
We
examine
various
such
as
Salmonella
sp.,
Campylobacter
Escherichia
coli,
Listeria
monocytogenes,
detailing
specific
of
concern
carcinogenic
mechanisms.
study
discusses
analytical
techniques
detecting
chromatography,
spectrometry,
immunoassays,
along
with
challenges
associated
detection.
covers
effective
control
strategies,
processing
techniques,
sanitation
practices,
regulatory
measures,
emerging
technologies
in
pathogen
control.
manuscript
considers
broader
highlighting
importance
robust
policies,
awareness,
education.
identifies
research
gaps
innovative
approaches,
recommending
advancements
detection
methods,
preventive
policy
improvements
better
manage
foodborne
metabolites.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(14), С. 7530 - 7530
Опубликована: Июль 9, 2024
Aging
is
a
multifaceted
process
influenced
by
hereditary
factors,
lifestyle,
and
environmental
elements.
As
time
progresses,
the
human
body
experiences
degenerative
changes
in
major
functions.
The
external
internal
signs
of
aging
manifest
various
ways,
including
skin
dryness,
wrinkles,
musculoskeletal
disorders,
cardiovascular
diseases,
diabetes,
neurodegenerative
cancer.
Additionally,
cancer,
like
aging,
complex
disease
that
arises
from
accumulation
genetic
epigenetic
alterations.
Circadian
clock
dysregulation
has
recently
been
identified
as
an
important
risk
factor
for
cancer
development.
Natural
compounds
herbal
medicines
have
gained
significant
attention
their
potential
preventing
age-related
diseases
inhibiting
progression.
These
demonstrate
antioxidant,
anti-inflammatory,
anti-proliferative,
pro-apoptotic,
anti-metastatic,
anti-angiogenic
effects
well
circadian
regulation.
This
review
explores
cancers,
specific
natural
targeting
key
features
these
conditions.
Microorganisms,
Год журнала:
2025,
Номер
13(1), С. 177 - 177
Опубликована: Янв. 16, 2025
The
medicinal
potential
of
plant
extracts,
especially
their
antimicrobial,
antioxidant,
antiviral
and
cytotoxic
properties,
has
gained
significant
attention
in
recent
years.
This
study
examined
the
vitro
bioactivities
several
selected
Greek
plants,
like
Eucalyptus
globulus
L.,
Thymus
vulgaris
Salvia
rosmarinus
L.
Ocimum
basilicum
are
well-known
for
traditional
therapeutic
use.
Minimum
inhibitory
concentration
(MIC)
assays
were
used
to
evaluate
antimicrobial
activity
extracts
against
pathogenic
bacteria.
antioxidant
was
carried
out
using
DPPH
method,
while
cytotoxicity
plants
determined
Alamar
Blue
method.
In
addition,
efficacy
samples
tested
DENV
different
cell
lines.
majority
herbs
demonstrated
action
(MIC
=
30–3000
μg∙mL−1).
showed
great
activity,
extract
turned
be
most
effective
(IC50
12.89
±
0.11
contrast,
had
lowest
71.02
0.42
results
method
presented
with
CC50
values,
it
shown
that
exhibited
highest
(CC50
5.94%
v/v
0.04).
Similarly,
expressed
as
EC50
characterized
sample
dengue
virus
infection,
values
estimated
at
2.37%
0.6
(HuhD-2
cells
infected
DENV-2)
0.36%
0.004
(Huh7.5
DVR2A).
These
findings
provide
a
foundation
further
studies
order
combat
infectious
diseases
promote
human
health.
Gels,
Год журнала:
2025,
Номер
11(2), С. 106 - 106
Опубликована: Фев. 2, 2025
Oxidative
stress
plays
a
crucial
role
in
chronic
nasal
disorders,
contributing
to
inflammation,
tissue
damage,
and
impaired
mucosal
function,
highlighting
the
need
for
targeted
therapies.
Recent
advancements
drug
delivery
systems
have
expanded
their
applications
treating
respiratory
inflammatory
conditions.
Among
these,
hydrogel-based
offer
prolonged
release
of
active
pharmaceutical
ingredients
(APIs),
enhancing
therapeutic
efficacy
reducing
dosing
frequency.
This
study
initially
evaluates
antioxidant,
anti-inflammatory,
antimicrobial,
cytotoxic
properties
Nanotriphala,
followed
by
its
incorporation
into
thermoresponsive
situ
hydrogel
system,
which
was
subsequently
developed
characterized
as
novel
formulation.
Nanotriphala
exhibited
>90%
cell
viability
significantly
reduced
nitric
oxide
(NO)
levels
40.55
µg/mL
at
250
µg/mL.
The
key
parameters,
including
viscosity,
gelling
time,
pH,
temperature,
texture
analysis,
ex
vivo
spreadability.
Stability
assessed
under
various
conditions,
mutagenicity
antimutagenicity
were
evaluated
using
Ames
test.
Results
showed
that
gelled
34
°C,
good
spreadability
(10.25
±
0.28
cm),
viscosity
227
22
cP,
maintained
pH
5.75
0.01,
with
optimal
hardness
adhesiveness
suitable
application.
It
demonstrated
antimicrobial
activity
against
E.
coli,
P.
aeruginosa,
S.
aureus,
epidermidis
minimal
bactericidal
concentrations
(MBCs)
32,
2,
4,
8
µg/mL,
respectively,
low
(mutagenic
index
<
2)
strong
antimutagenic
(>60%).
gallic
acid
content
0.5796
0.0218
µg/100
mL.
studies
confirmed
storage
4
°C.
These
findings
suggest
loaded
is
promising
system
managing
oxidative
related
Annals of Animal Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 15, 2025
Abstract
This
study
aimed
to
evaluate
the
effects
of
Bay
laurel
leaf
extract
conjugated
with
zinc
nanoparticles
(Zn-Nano-BLLE)
as
a
growth
enhancer
and
antibiotic
alternative
in
broiler
diets
on
performance,
carcass
characteristics,
blood
markers.
In
completely
randomized
design,
264
one-day-old
Ross
308
chicks
were
divided
into
four
experimental
groups
assess
impact
Zn-Nano-BLLE
supplementation.
Each
group
consisted
six
replicates,
each
containing
11
unsexed
chicks.
The
treatments
follows:
control
(basal
diet)
without
any
additives,
three
receiving
at
1,
2,
3
cm³
Zn-Nano-BLLE/kg
feed,
respectively.
Results
indicated
that
supplementation
1
or
cm³/kg
feed
led
significant
improvements
live
body
weight
gain.
lowest
intake
conversion
ratio
observed
broilers
supplemented
(30.94
1.14,
respectively).
However,
highest
dressing,
carcass,
heart
percentages
found
group.
Additionally,
fed
showed
levels
total
protein,
albumin,
globulin,
while
also
exhibiting
cholesterol
low-density
lipoprotein
(161.52
88.35,
immunoglobulin
G
(IgG)
elevated
groups,
although
no
noted
M
(IgM).
Birds
given
2
demonstrated
superoxide
dismutase
activity
(164
U/ml),
had
levels.
conclusion,
dietary
inclusion
Zn-Nano-BLLE,
particularly
cm³/kg,
enhanced
immunity,
productivity,
antioxidant
status,
indicates
its
effectiveness
natural
production.
