International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(23), С. 12712 - 12712
Опубликована: Ноя. 26, 2024
Reconstructing
the
orbit
following
complex
craniofacial
fractures
presents
significant
challenges.
Throughout
years,
several
materials
have
been
used
for
orbital
reconstruction,
taking
into
account
factors
such
as
their
durability,
compatibility
with
living
tissue,
cost
efficiency,
safety,
and
capacity
to
be
adjusted
during
surgery.
Nevertheless,
a
consensus
has
not
yet
reached
on
optimal
material
restoration.
This
study
investigates
potential
of
hybrid
hydroxyapatite–collagen
(HAp-COL)
3D-printed
Ti
mesh
an
implant
wall
reconstruction.
HAp-COL
powder
was
synthesized
using
high-pressure
hydrothermal
technique.
The
further
3D-print
structures
titanium
mesh,
latter
having
uses
in
Biocompatibility
assessed
by
evaluating
effects
adhesion
proliferation
fibroblasts
(3T3)
mesenchymal
stem
cells
(MSCs)
culture.
In
vitro
vivo
results
showed
that
is
highly
biocompatible
good
integration
bone.
findings
reported
this
offer
convincing
evidence
support
use
our
designed
restoration
fractures,
high
level
safety.
Heliyon,
Год журнала:
2024,
Номер
10(16), С. e36258 - e36258
Опубликована: Авг. 1, 2024
Natural
bone
tissue
has
the
certain
function
of
self-regeneration
and
repair,
but
it
is
difficult
to
repair
large
damage.
Recently,
although
autologous
grafting
"gold
standard"
for
improving
high
cost,
few
donor
sources.
Besides,
allogeneic
causes
greater
immune
reactions,
which
hardly
meet
clinical
needs.
The
engineering
(BTE)
been
developed
promote
repair.
Gelatin,
due
its
biocompatibility,
receives
a
great
deal
attention
in
BTE
research
field.
However,
disadvantages
natural
gelatin
are
poor
mechanical
properties
single
structural
property.
With
development
BTE,
often
used
combination
with
range
natural,
synthetic
polymers,
inorganic
materials
achieve
synergistic
effects
complex
physiological
process
review
delves
into
fundamental
structure
unique
gelatin,
as
well
excellent
necessary
scaffold
materials.
Then
this
explores
application
modified
three-dimensional
(3D)
scaffolds
various
structures
including
3D
fiber
scaffolds,
hydrogels,
nanoparticles.
In
addition,
focuses
on
efficacy
composite
consisting
or
polymeric
materials,
bioactive
ceramics
metallic/non-metallic
defects.
these
gelatin-based
provides
new
ideas
design
good
biosafety.
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Авг. 21, 2024
Bone
defects
pose
significant
challenges
in
healthcare,
with
over
2
million
bone
repair
surgeries
performed
globally
each
year.
As
a
burgeoning
force
the
field
of
tissue
engineering,
3D
printing
offers
novel
solutions
to
traditional
transplantation
procedures.
However,
current
3D-printed
scaffolds
still
face
three
critical
material
selection,
methods,
cellular
self-organization
and
co-culture,
significantly
impeding
their
clinical
application.
In
this
comprehensive
review,
we
delve
into
performance
criteria
that
ideal
should
possess,
particular
focus
on
core
faced
by
technology
during
translation.
We
summarize
latest
advancements
non-traditional
materials
advanced
techniques,
emphasizing
importance
integrating
organ-like
technologies
bioprinting.
This
combined
approach
enables
more
precise
simulation
natural
structure
function.
Our
aim
writing
review
is
propose
effective
strategies
address
these
promote
translation
for
defect
treatment.
Nanomaterials,
Год журнала:
2025,
Номер
15(3), С. 196 - 196
Опубликована: Янв. 26, 2025
Current
investigations
into
the
fabrication
of
innovative
biomaterials
that
stimulate
cartilage
development
result
from
increasing
interest
due
to
emerging
bone
defects.
In
particular,
investigation
for
musculoskeletal
therapies
extensively
depends
on
various
hydroxyapatite
(HA)/sodium
alginate
(SA)
composites.
Cuttlefish
(CFB)-derived
composite
scaffolds
hard
tissue
regeneration
have
been
effectively
illustrated
in
this
using
a
hydrothermal
technique.
this,
HA
was
prepared
CFB
source
without
altering
its
biological
properties.
The
as-developed
nanocomposites
were
investigated
through
XRD,
FTIR,
SEM,
and
EDX
analyses
confirm
their
structural,
functional,
morphological
orientation.
higher
interfacial
density
HA/SA
nanocomposites,
more
hardness
scaffold
increased
with
applied
load.
Furthermore,
nanocomposite
revealed
remarkable
antibacterial
activity
against
bacterial
strains
such
as
E.
coli
S.
aureus
inhibition
zones
measured
18
mm
20
mm,
respectively.
results
demonstrated
minor
decrease
cell
viability
compared
untreated
culture,
an
observed
percentage
at
97.2%
nanocomposites.
Hence,
proposed
would
be
excellent
alternative
engineering
applications.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(7), С. 3085 - 3085
Опубликована: Март 27, 2025
In
recent
years,
the
management
of
bone
defects
in
regenerative
medicine
and
orthopedic
surgery
has
been
subject
extensive
research
efforts.
The
complexity
fractures
loss
arising
from
trauma,
degenerative
conditions,
or
congenital
disorders
necessitates
innovative
therapeutic
strategies
to
promote
effective
healing.
Although
tissue
exhibits
an
intrinsic
capacity,
critical-sized
can
severely
compromise
this
process,
often
requiring
grafts
substitutes.
Tissue
engineering
approaches
within
have
introduced
novel
possibilities
for
addressing
nonunions
challenging
refractory
conventional
treatment
methods.
Key
components
field
include
stem
cells,
bioactive
growth
factors,
biocompatible
scaffolds,
with
a
strong
focus
on
advancements
substitute
materials.
Both
natural
synthetic
substitutes
present
distinct
characteristics
applications.
Natural
grafts-comprising
autologous,
allogeneic,
xenogeneic
materials-offer
biological
advantages,
while
alternatives,
including
biodegradable
non-biodegradable
biomaterials,
provide
structural
versatility
reduced
immunogenicity.
This
review
provides
comprehensive
analysis
diverse
grafting
alternatives
utilized
surgery,
emphasizing
persistent
challenges.
By
exploring
both
substitutes,
work
offers
in-depth
examination
cutting-edge
solutions,
fostering
further
innovation
complex
defects.
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 18, 2025
Abstract
Repair
and
reconstruction
of
critical‐sized
bone
defects
present
a
significant
challenge
due
to
poor
clinical
outcomes
conventional
repair
strategies,
such
as
autologous
allogenic
grafts.
The
study
underscores
the
potential
human
dental
pulp
stem
cell‐derived
trophic
factors
promote
regeneration,
thus
evading
risks
associated
with
cell‐based
therapy.
This
utilizes
pre‐osteoblast
cells
evaluate
osteogenic
2
Dimensional
(2D)
3
(3D)
secretome
from
monolayer
spheroid
cultures
(DPSCs),
respectively.
In‐vitro
results
on
(MC3T3‐EI)
treated
2D
3D
reveal
lower
mineralization
mRNA
expression
specific
genes
in
comparison
secretome.
Furthermore,
shows
better
regeneration
ability
rat
models
calvarial
defect
compared
proteomic
profiles
secretomes
are
also
concordance
these
key
molecules
governing
potential.
data
highlights
influence
culture
conditions
secretory
pattern
mesenchymal
provides
valuable
insights
for
development
more
effective
secretome‐based
cell‐free
alternative
novel
regeneration.
EFORT Open Reviews,
Год журнала:
2024,
Номер
9(9), С. 837 - 844
Опубликована: Сен. 1, 2024
Advanced
therapies
are
expected
to
play
a
crucial
role
in
supporting
repair
after
injury,
halting
the
degeneration
of
musculoskeletal
tissue
enable
and
promote
physical
activity.
Despite
advancements,
progress
developing
advanced
orthopaedics
lags
behind
specialties
like
oncology,
since
innovative
regenerative
treatment
strategies
fall
short
their
expectations
clinical
trials.
Researchers
should
focus
on
understanding
mechanism
action
investigated
target
before
conducting
Strategic
research
networks
needed
that
not
only
enhance
scientific
exchange
among
like-minded
researchers
but
need
include
early
commercial
views,
companies
venture
perspectives,
regulatory
insights
reimbursement
perspectives.
Only
such
collaborations
essential
roadblocks
towards
trials
go-to-patients
be
overcome.
Abstract
Critical‐sized
bone
defects
represent
an
urgent
clinical
problem,
necessitating
innovative
treatment
approaches.
Gene‐activated
grafts
for
tissue
engineering
have
emerged
as
a
promising
solution.
However,
traditional
gene
delivery
methods
are
constrained
by
limited
osteogenic
efficacy
and
safety
concerns.
Recently,
organic
inorganic
nanoparticle
(NP)
vectors
attracted
significant
attention
in
their
safe,
stable,
controllable
delivery.
Targeted
guided
insights
into
healing
mechanisms,
coupled
with
the
multifunctional
design
of
NPs,
is
crucial
enhancing
therapeutic
outcomes.
Here,
theoretical
foundations
underlying
NP‐mediated
therapy
across
different
histological
stages
elucidated.
Furthermore,
distinct
attributes
functionalized
NP
discussed,
cutting‐edge
strategies
aimed
at
optimizing
efficiency
throughout
process
highlighted.
Additionally,
review
addresses
unresolved
challenges
prospects
this
technology.
This
may
contribute
to
continued
development
application
treating
critical‐sized
defects.
