Biomedicines,
Год журнала:
2024,
Номер
12(11), С. 2514 - 2514
Опубликована: Ноя. 3, 2024
Background/Objectives:
Neuroinflammation
is
associated
with
the
progression
of
various
brain
diseases,
and
management
neuroinflammation-induced
neural
damage
a
crucial
aspect
treating
neurological
disorders.
This
study
investigated
anti-inflammatory
efficacy
photobiomodulation
therapy
(PBMT)
using
660
nm
phototherapy
in
rat
model
lipopolysaccharide
(LPS)-induced
neuroinflammation.
Methods:
We
induced
inflammation
brains
via
intraperitoneal
injection
LPS
subjected
treatment
group
to
examine
its
protective
effect
against
hippocampal
based
on
pathological,
histological,
immunohistochemical
tissue
analyses.
Results:
The
treated
rats
showed
significant
decrease
structural
cell
death
compared
LPS-treated
group.
observed
reduced
expression
markers
GFAP,
TNF-α,
IL-1β
hippocampus
group,
an
increase
SIRT1
across
all
regions.
Conclusions:
presents
promising
method
for
controlling
neuroinflammation
providing
neuroprotection
relief.
PBMT
represents
non-invasive
therapeutic
approach
minimal
side
effects
ensured
through
proper
control
light
irradiation.
Journal of dementia and Alzheimer's disease,
Год журнала:
2024,
Номер
1(2), С. 87 - 97
Опубликована: Окт. 15, 2024
Endoplasmic
reticulum
(ER)
stress
is
a
detrimental
cellular
phenomenon
in
the
cells
and
activated
by
accumulation
of
unfolded
or
misfolded
proteins
ER.
The
protein
activates
response
(UPR),
an
adaptive
mechanism
designed
to
mitigate
enhancing
ER’s
protein-folding
capacity
protecting
from
apoptotic
stimuli
neuroinflammation
neurodegenerative
diseases.
However,
chronic
ER
prolonged
activation
UPR
can
have
adverse
effects,
including
pro-apoptotic
inflammatory
signaling
pathways,
which
contribute
development
progression
disorders.
Neurodegenerative
diseases
are
complex
devastating
conditions
with
underlying
pathogenesis
that
not
fully
understood.
Genetic
mutations
leading
phosphorylated
tau
amyloid-beta
induce
stress,
resulting
neuronal
death.
Several
studies
reported
involvement
increased
Thus,
inhibiting
targeting
their
associated
pathways
represent
significant
area
research
interest.
This
review
discusses
critical
molecules
involved
mechanisms
diseases,
latest
developments
available
inhibitors.
Despite
extensive
inhibitors
over
years,
only
limited
number
been
approved
as
pharmaceutical
drugs.
There
remains
need
for
effective
provide
efficient
treatments
Alzheimer’s
disease.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(22), С. 11941 - 11941
Опубликована: Ноя. 6, 2024
The
identification
of
neuroinflammation
as
a
critical
factor
in
Alzheimer's
disease
(AD)
has
expanded
the
focus
research
beyond
amyloid-β
and
tau
pathology.
neuroinflammatory
fluid
biomarkers
GFAP,
sTREM2,
YKL-40
have
gained
attention
for
their
potential
early
detection
monitoring
progression.
Plasma
GFAP
demonstrated
promise
predicting
conversion
from
mild
cognitive
impairment
to
AD
dementia,
while
sTREM2
highlights
microglial
activation,
although
there
are
conflicting
results
regarding
its
dynamics
pathogenesis.
Advanced
imaging
techniques,
such
PET
tracers
targeting
TSPO
MAO-B,
also
been
developed
visualize
glial
activation
vivo,
offering
spatial
temporal
insights
into
processes.
However,
clinical
implementation
these
faces
challenges
due
lack
specificity,
many
them
can
be
elevated
other
conditions.
Therapeutic
strategies
emerging,
with
TREM2-targeting
therapies
antidiabetic
drugs
like
GLP-1
receptor
agonists
showing
modulating
activity.
Nevertheless,
complexity
neuroinflammation,
which
encompasses
both
protective
harmful
responses,
necessitates
further
fully
unravel
role
optimize
therapeutic
approaches
AD.
Cancers,
Год журнала:
2024,
Номер
16(15), С. 2680 - 2680
Опубликована: Июль 27, 2024
The
link
between
neurodegenerative
diseases
(NDs)
and
cancer
has
generated
greater
interest
in
biomedical
research,
with
decades
of
global
studies
investigating
biomarkers
to
better
understand
possible
connections.
Tau,
amyloid-β,
α-synuclein,
SOD1,
TDP-43,
other
proteins
associated
nervous
system
have
also
been
identified
various
types
solid
malignant
tumors,
suggesting
a
potential
overlap
pathological
processes.
In
this
review,
we
aim
provide
an
overview
current
evidence
on
the
role
these
cancer,
specifically
examining
their
effects
cell
proliferation,
apoptosis,
chemoresistance,
tumor
progression.
Additionally,
discuss
diagnostic
therapeutic
implications
interconnection,
emphasizing
importance
further
research
completely
comprehend
clinical
tumors.
Finally,
explore
challenges
opportunities
targeting
for
development
new
targeted
anticancer
therapies,
providing
insight
into
how
integrate
knowledge
NDs
oncology
research.
Cellular and Molecular Life Sciences,
Год журнала:
2024,
Номер
81(1)
Опубликована: Авг. 17, 2024
Parkinson's
disease
(PD)
is
the
second
most
common
neurodegenerative
disease,
and
its
hallmark
pathological
features
are
loss
of
dopaminergic
(DA)
neurons
in
midbrain
substantia
nigra
pars
compacta
(SNpc)
accumulation
alpha-synuclein
(α-syn).
It
has
been
shown
that
integrity
blood-brain
barrier
(BBB)
damaged
PD
patients,
a
large
number
infiltrating
T
cells
inflammatory
cytokines
have
detected
cerebrospinal
fluid
(CSF)
brain
parenchyma
patients
animal
models,
including
significant
change
proportion
different
CD4
Healthcare,
Год журнала:
2024,
Номер
12(19), С. 1957 - 1957
Опубликована: Окт. 1, 2024
Background.
Caregiver
affiliate
stigma
concerning
neurodegenerative
disorders
(NDDs)
profoundly
affects
caregivers'
well-being,
though
its
full
impact
remains
to
be
fully
elucidated.
Objectives.
This
scoping
review
aims
consolidate
the
current
knowledge
on
caregiver
related
NDDs,
explore
connection
psychosocial
and
pinpoint
gaps
in
existing
research.
Methods.
Adhering
PRISMA-ScR
guidelines,
a
comprehensive
search
of
five
databases
was
conducted
for
peer-reviewed,
English
language
studies
focusing
caregiver-affiliated
relation
NDDs.
Results.
The
initial
yielded
9033
articles,
with
19
meeting
inclusion
criteria
after
rigorous
screening.
Bronfenbrenner's
ecological
systems
theory
employed
analyze
various
conceptualizations,
including
public,
courtesy,
affiliate,
family
stigma.
Analysis
revealed
correlation
between
elevated
levels
increased
burden,
deteriorated
mental
health
outcomes,
diminished
quality
life.
internalization
found
vary
across
demographic
groups,
influenced
by
factors
such
as
education
level
social
support.
also
highlighted
mediating
role
coping
strategies
protective
function
support
against
internalization.
Conclusions,
These
findings
underscore
necessity
targeted,
culturally
sensitive
interventions
that
address
multiple
levels.
contributes
more
nuanced
understanding
laying
groundwork
future
research
intervention
development
aimed
at
enhancing
well-being
diverse
cultural
contexts.
Bioscience Reports,
Год журнала:
2024,
Номер
44(11)
Опубликована: Ноя. 1, 2024
Parkinson's
disease
(PD)
significantly
affects
millions
of
people
worldwide
due
to
the
progressive
degeneration
dopamine-producing
neurons
in
substantia
nigra
pars
compacta.
Despite
extensive
research
efforts,
effective
treatments
that
can
halt
or
reverse
progression
PD
remain
elusive.
In
recent
years,
nanotechnology
has
emerged
as
a
promising
new
avenue
for
addressing
this
challenge,
with
zinc
oxide
nanoparticles
(ZnO-NPs)
standing
out
their
therapeutic
potential.
ZnO-NPs
have
shown
remarkable
promise
neuroprotection
through
several
key
mechanisms.
The
multifaceted
properties
suggest
they
could
play
crucial
role
intervening
across
various
fundamental
mechanisms
implicated
PD.
By
targeting
these
mechanisms,
offer
insights
and
potential
strategies
managing
treating
This
review
aims
provide
thorough
examination
molecular
which
exert
neuroprotective
effects.
It
highlights
innovative
agents
outlines
directions
future
explore
harness
full
capabilities.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(18), С. 9859 - 9859
Опубликована: Сен. 12, 2024
Histamine
(HA),
a
biogenic
monoamine,
exerts
its
pleiotropic
effects
through
four
H1R–H4R
histamine
receptors,
which
are
also
expressed
in
brain
tissue.
Together
with
the
projections
of
HA-producing
neurons
located
within
tuberomammillary
nucleus
(TMN),
innervate
most
areas
brain,
they
constitute
histaminergic
system.
Thus,
while
remaining
mediator
inflammatory
reaction
and
immune
system
function,
HA
acts
as
neurotransmitter
modulator
other
systems
central
nervous
(CNS).
Although
detailed
causes
still
not
fully
understood,
neuroinflammation
seems
to
play
crucial
role
etiopathogenesis
both
neurodevelopmental
neurodegenerative
(neuropsychiatric)
diseases,
such
autism
spectrum
disorders
(ASDs),
attention-deficit/hyperactivity
disorder
(ADHD),
Alzheimer’s
disease
(AD)
Parkinson’s
(PD).
Given
increasing
prevalence/diagnosis
these
their
socioeconomic
impact,
need
develop
effective
forms
therapy
has
focused
researchers’
attention
on
brain’s
activity
related
signaling
pathways.
This
review
presents
current
state
knowledge
concerning
involvement
CNS
development
disorders.
To
this
end,
roles
neurotransmission,
neuroinflammation,
neurodevelopment
discussed.
