Association of Hematopoietic Loss of Y Chromosome With Atrial Fibrillation Incidence and Sex Disparity
JACC Basic to Translational Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Язык: Английский
Large-scale analysis of loss of chromosome Y in human pluripotent stem cells: Implications for Turner syndrome and ribosomopathies
Stem Cell Reports,
Год журнала:
2025,
Номер
unknown, С. 102471 - 102471
Опубликована: Апрель 1, 2025
Loss
of
chromosome
Y
(LOY)
occurs
in
aging
and
cancers,
but
its
extent
implications
human
embryonic
stem
cells
(hESCs)
have
not
been
studied.
Here,
we
analyzed
over
2,650
RNA
sequencing
(RNA-seq)
samples
from
hESCs
their
differentiated
derivatives
to
detect
LOY.
We
found
that
12%
hESC
lost
identified
LOY
all
three
germ
layers.
Differential
expression
analysis
revealed
showed
a
decrease
pluripotency
markers
ribosomal
protein
(RP)
genes.
Strikingly,
significant
RP
transcription
downregulation
was
observed
most
genes,
although
there
is
only
one
expressed
Y-linked
gene.
further
Turner
syndrome
Diamond-Blackfan
anemia
overall
transcription.
This
broad
sheds
light
on
the
scope
effects
hESCs,
suggesting
novel
dosage-sensitive
mechanism
regulating
gene
autosomal
ribosomopathies.
Язык: Английский
Sex Differences in Cardiovascular Diseases: Exploring the Role of Microbiota and Immunity
Biomedicines,
Год журнала:
2024,
Номер
12(8), С. 1645 - 1645
Опубликована: Июль 24, 2024
Cardiovascular
diseases
(CVDs)
are
the
most
common
cause
of
mortality
and
morbidity
in
Western
countries,
thus
representing
a
global
health
concern.
CVDs
show
different
patterns
terms
prevalence
presentation
men
women.
The
role
sex
hormones
has
been
extensively
implicated
these
sex-specific
differences,
due
to
presence
menstrual
cycle
menopause
Moreover,
gut
microbiota
(GM)
cardiovascular
health,
considering
growing
evidence
that
it
is
involved
determining
development
specific
diseases.
In
particular,
gut-derived
metabolites
have
linked
kidney
disorders,
which
can
turn
promote
progression
CVDs.
Considering
differences
composition
GM
between
women,
possible
act
as
mediator
regard
disparities
This
narrative
review
aims
comprehensively
interplay
sex,
GM,
CVDs,
discussing
potential
mechanisms
therapeutic
options.
Язык: Английский
Sex as a biological variable in ageing: insights and perspectives on the molecular and cellular hallmarks
Open Biology,
Год журнала:
2024,
Номер
14(10)
Опубликована: Окт. 1, 2024
Sex-specific
differences
in
lifespan
and
ageing
are
observed
various
species.
In
humans,
women
generally
live
longer
but
frailer
suffer
from
different
age-related
diseases
compared
to
men.
The
hallmarks
of
ageing,
such
as
genomic
instability,
telomere
attrition
or
loss
proteostasis,
exhibit
sex-specific
patterns.
Sex
chromosomes
sex
hormones,
well
the
epigenetic
regulation
inactive
X
chromosome,
have
been
shown
affect
diseases.
Here
we
review
current
knowledge
on
biological
basis
sex-biased
ageing.
While
our
is
focused
also
discuss
examples
model
organisms
mouse,
fruit
fly
killifish.
Understanding
these
molecular
crucial
elderly
population
expected
double
worldwide
by
2050,
making
approaches
diagnosis,
treatment,
therapeutic
development
prevention
a
pressing
need.
Язык: Английский