Sex as a biological variable in ageing: insights and perspectives on the molecular and cellular hallmarks DOI Creative Commons

José Héctor Gibrán Fritz García,

Claudia Isabelle Keller Valsecchi, M. Felicia Basilicata

et al.

Open Biology, Journal Year: 2024, Volume and Issue: 14(10)

Published: Oct. 1, 2024

Sex-specific differences in lifespan and ageing are observed various species. In humans, women generally live longer but frailer suffer from different age-related diseases compared to men. The hallmarks of ageing, such as genomic instability, telomere attrition or loss proteostasis, exhibit sex-specific patterns. Sex chromosomes sex hormones, well the epigenetic regulation inactive X chromosome, have been shown affect diseases. Here we review current knowledge on biological basis sex-biased ageing. While our is focused also discuss examples model organisms mouse, fruit fly killifish. Understanding these molecular crucial elderly population expected double worldwide by 2050, making approaches diagnosis, treatment, therapeutic development prevention a pressing need.

Language: Английский

Association of Hematopoietic Loss of Y Chromosome With Atrial Fibrillation Incidence and Sex Disparity DOI Creative Commons
Tianqi Ma, Chen Zhu, Xunjie Cheng

et al.

JACC Basic to Translational Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Large-scale analysis of loss of chromosome Y in human pluripotent stem cells: Implications for Turner syndrome and ribosomopathies DOI Creative Commons

Roni Sarel-Gallily,

Keith M. Gunapala, Nissim Benvenisty

et al.

Stem Cell Reports, Journal Year: 2025, Volume and Issue: unknown, P. 102471 - 102471

Published: April 1, 2025

Loss of chromosome Y (LOY) occurs in aging and cancers, but its extent implications human embryonic stem cells (hESCs) have not been studied. Here, we analyzed over 2,650 RNA sequencing (RNA-seq) samples from hESCs their differentiated derivatives to detect LOY. We found that 12% hESC lost identified LOY all three germ layers. Differential expression analysis revealed showed a decrease pluripotency markers ribosomal protein (RP) genes. Strikingly, significant RP transcription downregulation was observed most genes, although there is only one expressed Y-linked gene. further Turner syndrome Diamond-Blackfan anemia overall transcription. This broad sheds light on the scope effects hESCs, suggesting novel dosage-sensitive mechanism regulating gene autosomal ribosomopathies.

Language: Английский

Citations

0
Sex Differences in Cardiovascular Diseases: Exploring the Role of Microbiota and Immunity DOI Creative Commons
Laura Franza, Mario Caldarelli, Emanuele Rocco Villani

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(8), P. 1645 - 1645

Published: July 24, 2024

Cardiovascular diseases (CVDs) are the most common cause of mortality and morbidity in Western countries, thus representing a global health concern. CVDs show different patterns terms prevalence presentation men women. The role sex hormones has been extensively implicated these sex-specific differences, due to presence menstrual cycle menopause Moreover, gut microbiota (GM) cardiovascular health, considering growing evidence that it is involved determining development specific diseases. In particular, gut-derived metabolites have linked kidney disorders, which can turn promote progression CVDs. Considering differences composition GM between women, possible act as mediator regard disparities This narrative review aims comprehensively interplay sex, GM, CVDs, discussing potential mechanisms therapeutic options.

Language: Английский

Citations

1
Sex as a biological variable in ageing: insights and perspectives on the molecular and cellular hallmarks DOI Creative Commons

José Héctor Gibrán Fritz García,

Claudia Isabelle Keller Valsecchi, M. Felicia Basilicata

et al.

Open Biology, Journal Year: 2024, Volume and Issue: 14(10)

Published: Oct. 1, 2024

Sex-specific differences in lifespan and ageing are observed various species. In humans, women generally live longer but frailer suffer from different age-related diseases compared to men. The hallmarks of ageing, such as genomic instability, telomere attrition or loss proteostasis, exhibit sex-specific patterns. Sex chromosomes sex hormones, well the epigenetic regulation inactive X chromosome, have been shown affect diseases. Here we review current knowledge on biological basis sex-biased ageing. While our is focused also discuss examples model organisms mouse, fruit fly killifish. Understanding these molecular crucial elderly population expected double worldwide by 2050, making approaches diagnosis, treatment, therapeutic development prevention a pressing need.

Language: Английский

Citations

0