Apigenin as a Promising Agent for Enhancing Female Reproductive Function and Treating Associated Disorders
Biomedicines,
Год журнала:
2024,
Номер
12(10), С. 2405 - 2405
Опубликована: Окт. 21, 2024
Apigenin
is
an
organic
flavonoid
abundant
in
some
plants
such
as
parsley,
chamomile,
or
celery.
Recently,
it
has
been
investigated
for
several
of
its
pharmacological
characteristics,
ability
to
act
antioxidant,
reduce
inflammation,
and
inhibit
the
growth
cancer
cells.
The
purpose
this
review
provide
a
summary
existing
knowledge
regarding
effects
apigenin
on
female
reproductive
systems
dysfunctions.
can
influence
processes
by
regulating
multiple
biological
events,
including
oxidative
processes,
cell
proliferation,
apoptosis,
renewal
viability,
ovarian
blood
supply,
release
hormones.
It
could
stimulate
folliculogenesis,
well
embryonal
proliferation
which
lead
increase
fertility
hormones,
may
exert
health.
Furthermore,
activities
cells
alleviate
pathological
changes
system
caused
environmental
pollutants,
harmful
medications,
cancer,
polycystic
syndrome,
ischemia,
endometriosis.
Therefore,
have
potential
biostimulator
therapeutic
agent
certain
diseases.
Язык: Английский
Nicotinamide Mononucleotide Restores NAD+ Levels to Alleviate LPS-Induced Inflammation via the TLR4/NF-κB/MAPK Signaling Pathway in Mice Granulosa Cells
Antioxidants,
Год журнала:
2024,
Номер
14(1), С. 39 - 39
Опубликована: Дек. 31, 2024
Inflammation
disrupts
the
normal
function
of
granulosa
cells
(GCs),
which
leads
to
ovarian
dysfunction
and
fertility
decline.
Inflammatory
conditions
such
as
polycystic
ovary
syndrome
(PCOS),
primary
insufficiency
(POI),
endometriosis,
age-related
decline
are
often
associated
with
chronic
low-grade
inflammation.
Nicotinamide
mononucleotide
(NMN)
is
an
important
precursor
NAD+
has
gained
attention
for
its
potential
modulate
cellular
metabolism,
redox
homeostasis,
mitigate
This
study
investigated
protective
roles
NMN
against
lipopolysaccharide
LPS-mediated
inflammation
in
GCs.
The
results
this
experiment
demonstrated
that
LPS
had
negative
effects
on
GCs
term
reduced
viability
proliferation
rates
upregulated
production
pro-inflammatory
cytokines,
including
interleukin-1
beta
(IL-1β),
interleukin-6
(IL-6),
cyclooxygenase-2
(Cox-2),
tumor
necrosis
factor-alpha
(TNF-α).
Notably,
levels
NAD+/NADH
ratio
were
response
On
other
hand,
supplementation
restored
significantly
expression
markers
at
both
mRNA
protein
levels.
It
also
enhanced
cell
Furthermore,
apoptosis
by
downregulating
pro-apoptotic
markers,
Caspase-3,
Caspase-9,
Bax
while
upregulating
anti-apoptotic
marker
Bcl-2.
reactive
oxygen
species
ROS
improved
steroidogenesis
activity
restoring
estradiol
(E2)
progesterone
(P4)
LPS-treated
Mechanistically,
found
suppressed
activation
TLR4/NF-κB/MAPK
signaling
pathways
GCs,
regulates
inflammatory
processes.
In
conclusion,
findings
revealed
reduce
changes
modulating
metabolism
pathways.
can
be
used
a
therapeutic
agent
related
disorders.
Язык: Английский
Can we manipulate the ovary’s own metabolism to protect it from chemotherapy-induced damage?
EMBO Molecular Medicine,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 3, 2024
Язык: Английский
Changes in blood physiological and biochemical parameters and intestinal flora in newborn horses and mares with angular limb deformities
Frontiers in Veterinary Science,
Год журнала:
2024,
Номер
11
Опубликована: Ноя. 26, 2024
Angular
limb
deformities
(ALDs)
are
a
common
skeletal
development
disorder
in
newborn
foals.
This
condition
affects
the
growth
and
of
foals
severely
impacts
their
future
athletic
performance
economic
value,
causing
significant
financial
losses
to
horse
industry.
Placentitis,
metritis,
severe
metabolic
diseases
during
mare
pregnancy
causes
ALDs
It
has
been
established
that
intestinal
flora
disorders
can
easily
lead
inflammatory
host.
However,
incidence
Zhaosu
County,
Xinjiang,
key
production
area
China's
industry,
remains
unclear.
Additionally,
relationship
between
functional
changes
with
mares
is
not
well-understood.
Язык: Английский