Changes in blood physiological and biochemical parameters and intestinal flora in newborn horses and mares with angular limb deformities DOI Creative Commons
Yuhui Ma,

Yigang Liu,

Li Hai

et al.

Frontiers in Veterinary Science, Journal Year: 2024, Volume and Issue: 11

Published: Nov. 26, 2024

Angular limb deformities (ALDs) are a common skeletal development disorder in newborn foals. This condition affects the growth and of foals severely impacts their future athletic performance economic value, causing significant financial losses to horse industry. Placentitis, metritis, severe metabolic diseases during mare pregnancy causes ALDs It has been established that intestinal flora disorders can easily lead inflammatory host. However, incidence Zhaosu County, Xinjiang, key production area China's industry, remains unclear. Additionally, relationship between functional changes with mares is not well-understood.

Language: Английский

Apigenin as a Promising Agent for Enhancing Female Reproductive Function and Treating Associated Disorders DOI Creative Commons
Alexander V. Sirotkin, Abdel Halim Harrath

Biomedicines, Journal Year: 2024, Volume and Issue: 12(10), P. 2405 - 2405

Published: Oct. 21, 2024

Apigenin is an organic flavonoid abundant in some plants such as parsley, chamomile, or celery. Recently, it has been investigated for several of its pharmacological characteristics, ability to act antioxidant, reduce inflammation, and inhibit the growth cancer cells. The purpose this review provide a summary existing knowledge regarding effects apigenin on female reproductive systems dysfunctions. can influence processes by regulating multiple biological events, including oxidative processes, cell proliferation, apoptosis, renewal viability, ovarian blood supply, release hormones. It could stimulate folliculogenesis, well embryonal proliferation which lead increase fertility hormones, may exert health. Furthermore, activities cells alleviate pathological changes system caused environmental pollutants, harmful medications, cancer, polycystic syndrome, ischemia, endometriosis. Therefore, have potential biostimulator therapeutic agent certain diseases.

Language: Английский

Citations

1
Nicotinamide Mononucleotide Restores NAD+ Levels to Alleviate LPS-Induced Inflammation via the TLR4/NF-κB/MAPK Signaling Pathway in Mice Granulosa Cells DOI Creative Commons
Mehboob Ahmed, Umair Riaz,

Haimiao Lv

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 14(1), P. 39 - 39

Published: Dec. 31, 2024

Inflammation disrupts the normal function of granulosa cells (GCs), which leads to ovarian dysfunction and fertility decline. Inflammatory conditions such as polycystic ovary syndrome (PCOS), primary insufficiency (POI), endometriosis, age-related decline are often associated with chronic low-grade inflammation. Nicotinamide mononucleotide (NMN) is an important precursor NAD+ has gained attention for its potential modulate cellular metabolism, redox homeostasis, mitigate This study investigated protective roles NMN against lipopolysaccharide LPS-mediated inflammation in GCs. The results this experiment demonstrated that LPS had negative effects on GCs term reduced viability proliferation rates upregulated production pro-inflammatory cytokines, including interleukin-1 beta (IL-1β), interleukin-6 (IL-6), cyclooxygenase-2 (Cox-2), tumor necrosis factor-alpha (TNF-α). Notably, levels NAD+/NADH ratio were response On other hand, supplementation restored significantly expression markers at both mRNA protein levels. It also enhanced cell Furthermore, apoptosis by downregulating pro-apoptotic markers, Caspase-3, Caspase-9, Bax while upregulating anti-apoptotic marker Bcl-2. reactive oxygen species ROS improved steroidogenesis activity restoring estradiol (E2) progesterone (P4) LPS-treated Mechanistically, found suppressed activation TLR4/NF-κB/MAPK signaling pathways GCs, regulates inflammatory processes. In conclusion, findings revealed reduce changes modulating metabolism pathways. can be used a therapeutic agent related disorders.

Language: Английский

Citations

1
Can we manipulate the ovary’s own metabolism to protect it from chemotherapy-induced damage? DOI Creative Commons

Adomas Liugaila,

Agnes Stefansdottir, Norah Spears

et al.

EMBO Molecular Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 3, 2024

Language: Английский

Citations

0
Changes in blood physiological and biochemical parameters and intestinal flora in newborn horses and mares with angular limb deformities DOI Creative Commons
Yuhui Ma,

Yigang Liu,

Li Hai

et al.

Frontiers in Veterinary Science, Journal Year: 2024, Volume and Issue: 11

Published: Nov. 26, 2024

Angular limb deformities (ALDs) are a common skeletal development disorder in newborn foals. This condition affects the growth and of foals severely impacts their future athletic performance economic value, causing significant financial losses to horse industry. Placentitis, metritis, severe metabolic diseases during mare pregnancy causes ALDs It has been established that intestinal flora disorders can easily lead inflammatory host. However, incidence Zhaosu County, Xinjiang, key production area China's industry, remains unclear. Additionally, relationship between functional changes with mares is not well-understood.

Language: Английский

Citations

0