Medicine - Programa de Formación Médica Continuada Acreditado, Год журнала: 2024, Номер 14(23), С. 1350 - 1363
Опубликована: Дек. 1, 2024
Aging and Disease, Год журнала: 2025, Номер unknown, С. 0 - 0
Опубликована: Янв. 1, 2025
Circadian rhythm is the internal homeostatic physiological clock that regulates 24-hour sleep/wake cycle. This biological helps to adapt environmental changes such as light, dark, temperature, and behaviors. Aging, on other hand, a process of results in progressive decline cells, tissues, vital systems body. Both aging circadian are highly interlinked phenomena with bidirectional relationship. The leads disruptions while dysfunctional rhythms promote age-related complications. processes involve diverse physiological, molecular, cellular modifications DNA repair mechanisms, ROS generation, apoptosis, cell proliferation. review aims examine role context lung cancer. will also existing literature vice versa. Various molecular pathways genes BMAL1, SIRT1, HLF, PER1 their implications aging, rhythms, cancer be discussed.
Язык: Английский
Процитировано
0
Cell Communication and Signaling, Год журнала: 2025, Номер 23(1)
Опубликована: Янв. 16, 2025
The complex interaction between circadian rhythms and physiological functions is essential for maintaining human health. At the heart of this lies PERIOD proteins (PERs), pivotal to clock, influencing timing behavioral processes impacting oxidative stress, immune functionality, tumorigenesis. PER1 orchestrates cooperation enzyme GPX1, modulating mitochondrial dynamics in sync with daily thus regulating mechanisms managing energy substrates. PERs innate cells modulate temporal patterns NF-κB TNF-α activities, as well response LPS-induced toxic shock, initiating inflammatory responses that escalate into chronic conditions. Crucially, cancer cell behaviors including proliferation, apoptosis, migration by levels cycle stimulating expression oncogenes c-Myc MDM2. PER2/3, antagonists stem biology, play important roles differentiating their stemness. Importantly, Pers serve a significant factor early diagnosis prognosis. This review delves link rhythm regulator PERs, disruptions rhythm, oncogenesis. We examine evidence highlights how dysfunctions activities initiate development, aid tumor growth, modify metabolism through pathways involved stress system. Comprehending these connections opens new development rhythm-based therapeutic strategies, aims boosting enhancing treatments.
Язык: Английский
Процитировано
0
BMC Cancer, Год журнала: 2025, Номер 25(1)
Опубликована: Март 10, 2025
Circadian Syndrome (CircS) is a significant marker of metabolic imbalance and has been linked to various chronic diseases. However, its relationship with cancer risk remains underexplored. This research aims explore the between CircS cancer, while also assessing possible mediating role triglyceride glucose (TyG) index. Baseline data from 2011 China Health Retirement Longitudinal Study (CHARLS) follow-up 2015 were analyzed, including participants' sociodemographic characteristics, health behaviors, indicators. Linear regression, mediation analysis, logistic regression employed relationships CircS, risk, TyG index, dose-response analysis conducted on index risk. Among 7,864 middle-aged elderly participants, was significantly positively associated (r = 0.17, P < 0.001). The showed correlation both 0.52, 0.001) 0.15, Mediation modeling indicated that partially mediated association accounting for 23% this relationship. Additionally, nonlinear observed (Pnonlinear 0.0024). syndrome increased
Язык: Английский
Процитировано
0
Molecular and Cellular Probes, Год журнала: 2025, Номер unknown, С. 102027 - 102027
Опубликована: Март 1, 2025
Endometrial cancer is a significant public health concern with rising incidence rates globally. Understanding the molecular mechanisms underlying this disease crucial for developing effective therapeutic strategies. Our study aimed to characterize transcriptional changes in endometrial tissues compared adjusted healthy tissue. Using RNA sequencing, we identified 2483 differentially expressed genes (DEGs), including protein-coding genes, long non-coding RNAs (lncRNAs), and microRNAs (miRNAs). Notably, several known cancer-related were expressed, such as MYC, AKT3, CCND1, CDKN2A. Pathway analysis revealed alterations cell cycle regulation, signaling pathways, metabolic processes. These findings provide valuable insights into pathways dysregulated cancer. results may contribute development of novel targets biomarkers disease.
Язык: Английский
Процитировано
0
ONCOLOGIE, Год журнала: 2025, Номер unknown
Опубликована: Март 17, 2025
Язык: Английский
Процитировано
0
Asian Journal of Andrology, Год журнала: 2025, Номер unknown
Опубликована: Март 18, 2025
Abstract The circadian clock is an important internal time regulatory system for a range of physiological and behavioral rhythms within living organisms. Testosterone, as one the most critical sex hormones, essential development reproductive system, maintenance function, overall health males. secretion testosterone in mammals characterized by distinct closely associated with regulation genes. Here we review central peripheral mechanisms underlying influence genes upon synthesis. We also examined specific effects these on occurrence, development, treatment common male diseases, including late-onset hypogonadism, erectile dysfunction, infertility, prostate cancer.
Язык: Английский
Процитировано
0
Biopolymers and Cell, Год журнала: 2025, Номер 41(1), С. 23 - 31
Опубликована: Апрель 14, 2025
Язык: Английский
Процитировано
0
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Апрель 28, 2025
Circadian rhythm disruption is increasingly prevalent and associated with higher morbidity mortality. This study investigates the relationship between Rhythm Syndrome (CircS) mortality in middle-aged older adults. prospective cohort utilized follow-up data from China Health Retirement Longitudinal Study (CHARLS) National Nutrition Examination Survey (NHANES). Cox proportional hazards models examined association CircS all-cause mortality, while restricted cubic spline analysis explored non-linear relationships. Subgroup analyses investigated potential modifying factors. Bayesian generalized linear were used to explore relationships specific causes of death. The included 7,637 participants CHARLS (2011-2020) 9,320 NHANES (2005-2018), 142 1,321 deaths. periods 9.17 years for 15 NHANES. was significantly increased risk (CHARLS: HR 1.79, 95% CI: 1.23-2.62; NHANES: 1.21, 1.03-1.42). A dose-response observed number components risk. positively diabetes, cardiovascular, cerebrovascular, kidney-related diseases. strongly These findings underscore importance addressing circadian disruptions public health strategies.
Язык: Английский
Процитировано
0
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Окт. 7, 2024
Nutrition may affect animal health due to the strong link between them. Also, diets improve healing process in various disease states. Cancer is a disease, where harmful consequences of tumors severely impair body. The information regarding evolution this extrapolated from human because there are few specific studies nutritional needs animals with cancer. Thus, paper aims review literature immunomodulatory effects vitamins mammal An adequate understanding metabolism and requirements nutrients for mammals essential ensuring their optimal growth, development, health, regardless food sources. According these: 1) Some species highly dependent on vitamin D food, so special attention must be paid aspect. Calcitriol/VDR signaling can activate pro-apoptotic proteins suppress anti-apoptotic ones. 2) Nitric oxide (NO) production modulated by E through inhibiting transcription nuclear factor kappa B (NF-κB) activation. 3) Thiamine supplementation could responsible stimulation tumor cell proliferation, survival, resistance chemotherapy. 4) it was found that treatment NO-Cbl dogs viable anti-cancer therapy capitalizes tumor-specific properties B12 receptor. Therefore, should contain appropriate class compounds proportions. limitations some intensively studied at same time others, lack information, especially animals. subsections longer more heavily debated than others.
Язык: Английский
Процитировано
2
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(20), С. 10926 - 10926
Опубликована: Окт. 11, 2024
Circadian rhythms, the internal timekeeping systems governing physiological processes, significantly influence skin health, particularly in response to ultraviolet radiation (UVR). Disruptions circadian rhythms can exacerbate UVR-induced damage and increase risk of aging cancer. This review explores how affect various aspects physiology pathology, with a special focus on DNA repair. regulation ensures optimal repair following damage, reducing mutation accumulation, enhancing genomic stability. The control over cell proliferation apoptosis further contributes regeneration UVR. Oxidative stress management is another critical area where exert influence. Key genes like brain muscle ARNT-like 1 (BMAL1) locomotor output cycles kaput (CLOCK) modulate activity antioxidant enzymes signaling pathways protect cells from oxidative stress. also inflammatory immune responses by modulating Langerhans other skin. In summary, form complex defense network that manages through precise repair, proliferation, apoptosis, response, stress, hormonal signaling. Understanding these mechanisms provides insights into developing targeted protection improving cancer prevention.
Язык: Английский
Процитировано
1