The latest applications of exosome-mediated drug delivery in anticancer therapies
Colloids and Surfaces B Biointerfaces,
Год журнала:
2025,
Номер
249, С. 114500 - 114500
Опубликована: Янв. 6, 2025
Язык: Английский
Recent Exploration of Solid Cancer Biomarkers Hidden Within Urine or Blood Exosomes That Provide Fundamental Information for Future Cancer Diagnostics
Diagnostics,
Год журнала:
2025,
Номер
15(5), С. 628 - 628
Опубликована: Март 5, 2025
Cancer
cells
exhibit
abnormal
behavior
compared
to
normal
cells.
They
ignore
growth
arrest
signals
such
as
contact
inhibition,
a
mechanism
that
stops
their
proliferation
when
they
collide
with
surrounding
cells,
and
proliferate
in
an
uncontrolled
manner,
destroying
tissue.
Early
detection
treatment
of
cancer
are
therefore
important
for
healthy
longevity.
differ
from
characteristic
gene
expression
due
abnormalities.
markers
reflect
these
characteristics
have
been
searched
applied
diagnosis.
Although
analysis
blood
antigens
has
the
main
method,
further
development
diagnostic
system
is
needed
early
cancer.
Next-generation
sequencers
improved
technology,
making
it
possible
analyze
detailed
nucleic
acid
molecules
or
urine.
In
addition,
release
extracellular
vesicles,
exosomes,
which
known
contain
may
serve
markers.
This
review
summarizes
latest
findings
on
exosomal
Язык: Английский
Exploring the Spectrum of Long Non-Coding RNA CARMN in Physiological and Pathological Contexts
Biomolecules,
Год журнала:
2024,
Номер
14(8), С. 954 - 954
Опубликована: Авг. 6, 2024
Cardiac
mesoderm
enhancer-associated
non-coding
RNA
(CARMN),
an
evolutionarily
conserved
long
(lncRNA),
serves
as
the
host
gene
for
miR143/145
cluster.
It
plays
a
crucial
role
in
cardiovascular
cell
differentiation
and
maintenance
of
vascular
smooth
muscle
(VSMC)
homeostasis,
which
are
vital
normal
physiological
processes.
Specifically,
CARMN
is
associated
with
pathological
progression
diseases
such
atherosclerosis,
abdominal
aortic
aneurysm,
chronic
heart
failure.
Moreover,
it
acts
tumor
suppressor
various
cancers,
including
hepatocellular
carcinoma,
bladder
cancer,
breast
highlighting
its
potential
beneficial
biomarker
therapeutic
target.
This
review
provides
detailed
examination
roles
CARMN,
evolutionary
conservation,
expression
patterns,
regulatory
mechanisms.
also
outlines
significant
implications
diagnosis,
prognosis,
treatment
these
diseases,
underscoring
need
further
translational
research
to
exploit
clinical
potential.
Язык: Английский
Non-coding RNAs in bladder cancer, a bridge between gut microbiota and host?
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Ноя. 19, 2024
In
recent
years,
the
role
of
gut
microbiota
(GM)
in
bladder
cancer
has
attracted
significant
attention.
Research
indicates
that
GM
not
only
contributes
to
carcinogenesis
but
also
influences
efficacy
adjuvant
therapies
for
cancer.
Despite
this,
interventions
targeting
have
been
widely
employed
prevention
and
treatment
cancer,
mainly
due
incomplete
understanding
complex
interactions
between
host
flora.
Simultaneously,
aberrantly
expressed
non-coding
RNAs
(ncRNAs)
frequently
associated
with
playing
crucial
roles
processes
such
as
cell
proliferation,
invasion,
drug
resistance.
It
is
known
regulation
GM-mediated
pathophysiological
partly
regulated
through
epigenetic
pathways.
At
same
time,
ncRNAs
are
increasingly
regarded
signaling
molecules
involved
regulation.
Accordingly,
this
review
analyzes
closely
related
context
occurrence
treatment,
summarizes
their
interaction
cancer-related
phenotypes.
The
aim
delineate
a
regulatory
network
provide
new
perspective
study
Язык: Английский
MALAT1 and BCYRN1 lncRNAs expression in patients with breast cancer from Northwest Iran
Human Gene,
Год журнала:
2024,
Номер
43, С. 201370 - 201370
Опубликована: Дек. 12, 2024
Язык: Английский
LncRNA BC200 promotes the development of EBV-associated nasopharyngeal carcinoma by competitively binding to miR-6834-5p to upregulate TYMS expression
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
278, С. 134837 - 134837
Опубликована: Авг. 22, 2024
Язык: Английский
Epigenetic Biomarkers as a New Diagnostic Tool in Bladder Cancer—From Early Detection to Prognosis
Natalia Jaszek,
Alicja Bogdanowicz,
Jan Siwiec
и другие.
Journal of Clinical Medicine,
Год журнала:
2024,
Номер
13(23), С. 7159 - 7159
Опубликована: Ноя. 26, 2024
Bladder
cancer
(BC)
currently
ranks
as
the
9th
most
common
worldwide.
It
is
characterised
by
very
high
rates
of
recurrence
and
metastasis.
Most
cases
BC
are
urothelial
origin,
due
to
its
ability
penetrate
muscle
tissue,
divided
into
non-muscle-invasive
(NMIBC)
muscle-invasive
(MIBC).
The
current
diagnosis
still
based
primarily
on
invasive
cystoscopy,
which
an
expensive
method
that
carries
a
risk
various
complications.
Urine
sediment
cytology
often
used
complementary
test,
biggest
drawback
low
sensitivity
concerning
detection
at
early
stages,
crucial
for
prompt
implementation
appropriate
treatment.
Therefore,
there
great
need
develop
innovative
diagnostic
techniques
would
enable
accurate
prognosis
BC.
Great
potential
in
this
regard
shown
epigenetic
changes,
possible
observe
long
before
onset
clinical
symptoms
disease.
In
addition,
these
changes
can
be
detected
readily
available
biological
material,
such
urine
or
blood,
indicating
possibility
constructing
non-invasive
tests.
Over
past
few
years,
many
studies
have
emerged
using
alterations
novel
prognostic
biomarkers
This
review
provides
update
promising
DNA
methylation
expression
levels
selected
non-coding
RNAs
(ncRNAs),
taking
account
latest
literature
data.
Язык: Английский