Human Gene, Journal Year: 2024, Volume and Issue: 43, P. 201370 - 201370
Published: Dec. 12, 2024
Language: Английский
Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: 249, P. 114500 - 114500
Published: Jan. 6, 2025
Language: Английский
Citations
0
Diagnostics, Journal Year: 2025, Volume and Issue: 15(5), P. 628 - 628
Published: March 5, 2025
Cancer cells exhibit abnormal behavior compared to normal cells. They ignore growth arrest signals such as contact inhibition, a mechanism that stops their proliferation when they collide with surrounding cells, and proliferate in an uncontrolled manner, destroying tissue. Early detection treatment of cancer are therefore important for healthy longevity. differ from characteristic gene expression due abnormalities. markers reflect these characteristics have been searched applied diagnosis. Although analysis blood antigens has the main method, further development diagnostic system is needed early cancer. Next-generation sequencers improved technology, making it possible analyze detailed nucleic acid molecules or urine. In addition, release extracellular vesicles, exosomes, which known contain may serve markers. This review summarizes latest findings on exosomal
Language: Английский
Citations
0
Biomolecules, Journal Year: 2024, Volume and Issue: 14(8), P. 954 - 954
Published: Aug. 6, 2024
Cardiac mesoderm enhancer-associated non-coding RNA (CARMN), an evolutionarily conserved long (lncRNA), serves as the host gene for miR143/145 cluster. It plays a crucial role in cardiovascular cell differentiation and maintenance of vascular smooth muscle (VSMC) homeostasis, which are vital normal physiological processes. Specifically, CARMN is associated with pathological progression diseases such atherosclerosis, abdominal aortic aneurysm, chronic heart failure. Moreover, it acts tumor suppressor various cancers, including hepatocellular carcinoma, bladder cancer, breast highlighting its potential beneficial biomarker therapeutic target. This review provides detailed examination roles CARMN, evolutionary conservation, expression patterns, regulatory mechanisms. also outlines significant implications diagnosis, prognosis, treatment these diseases, underscoring need further translational research to exploit clinical potential.
Language: Английский
Citations
1
Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(23), P. 7159 - 7159
Published: Nov. 26, 2024
Bladder cancer (BC) currently ranks as the 9th most common worldwide. It is characterised by very high rates of recurrence and metastasis. Most cases BC are urothelial origin, due to its ability penetrate muscle tissue, divided into non-muscle-invasive (NMIBC) muscle-invasive (MIBC). The current diagnosis still based primarily on invasive cystoscopy, which an expensive method that carries a risk various complications. Urine sediment cytology often used complementary test, biggest drawback low sensitivity concerning detection at early stages, crucial for prompt implementation appropriate treatment. Therefore, there great need develop innovative diagnostic techniques would enable accurate prognosis BC. Great potential in this regard shown epigenetic changes, possible observe long before onset clinical symptoms disease. In addition, these changes can be detected readily available biological material, such urine or blood, indicating possibility constructing non-invasive tests. Over past few years, many studies have emerged using alterations novel prognostic biomarkers This review provides update promising DNA methylation expression levels selected non-coding RNAs (ncRNAs), taking account latest literature data.
Language: Английский
Citations
0
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 278, P. 134837 - 134837
Published: Aug. 22, 2024
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Nov. 19, 2024
In recent years, the role of gut microbiota (GM) in bladder cancer has attracted significant attention. Research indicates that GM not only contributes to carcinogenesis but also influences efficacy adjuvant therapies for cancer. Despite this, interventions targeting have been widely employed prevention and treatment cancer, mainly due incomplete understanding complex interactions between host flora. Simultaneously, aberrantly expressed non-coding RNAs (ncRNAs) frequently associated with playing crucial roles processes such as cell proliferation, invasion, drug resistance. It is known regulation GM-mediated pathophysiological partly regulated through epigenetic pathways. At same time, ncRNAs are increasingly regarded signaling molecules involved regulation. Accordingly, this review analyzes closely related context occurrence treatment, summarizes their interaction cancer-related phenotypes. The aim delineate a regulatory network provide new perspective study
Language: Английский
Citations
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Human Gene, Journal Year: 2024, Volume and Issue: 43, P. 201370 - 201370
Published: Dec. 12, 2024
Language: Английский
Citations
0