MDSC: a new potential breakthrough in CAR-T therapy for solid tumors DOI Creative Commons

Nada Mohamady Farouk Abdalsalam,

Abdulrahman Ibrahim,

Muhammad Auwal Saliu

и другие.

Cell Communication and Signaling, Год журнала: 2024, Номер 22(1)

Опубликована: Дек. 19, 2024

Chimeric antigen receptor T (CAR-T) cell therapy has shown remarkable success in hematologic malignancies but encountered challenges effectively treating solid tumors. One major obstacle is the presence of immunosuppressive tumor microenvironment (TME), which mainly built by myeloid-derived suppressor cells (MDSCs). Recent studies have that MDSCs a detrimental effect on CAR-T due to their potent capabilities. Targeting promising results enhance immunotherapy preclinical models. In this review, we first highlight increase proliferation, transition, angiogenesis and encourage circulating (CTCs) extravasation leading progression metastasis. Moreover, describe main characteristics activities TME. Most importantly, summarize targeting therapeutic strategies therapies against These include (1) through small molecule inhibitors large antibodies; (2) cancer combination with MDSC modulatory agents; (3) cytokine antigen-targeted indirectly or directly reshapes TME; (4) modified natural killer (NK) expressing activating MDSCs; (5) selective antigens. near future, are expected witness improvement for tumors clinical practice.

Язык: Английский

Exploring the Thioredoxin System as a Therapeutic Target in Cancer: Mechanisms and Implications DOI Creative Commons

Rebecca Seitz,

Deniz Tümen,

C Kunst

и другие.

Antioxidants, Год журнала: 2024, Номер 13(9), С. 1078 - 1078

Опубликована: Сен. 4, 2024

Cells constantly face the challenge of managing oxidants. In aerobic organisms, oxygen (O

Язык: Английский

Процитировано

7
Die Darm-Leber-Achse und die metabolische Dysfunktion-assoziierte steatotische Lebererkrankung DOI
Münevver Demir, Frank Tacke,

M Müller-Schilling

и другие.

Deleted Journal, Год журнала: 2025, Номер unknown

Опубликована: Фев. 28, 2025

Процитировано

0
Interaction between redox regulation, immune activation, and response to treatment in HER2+ breast cancer DOI Creative Commons
Paulo Luz, Sofı́a Ramos, Maria José Oliveira

и другие.

Redox Biology, Год журнала: 2025, Номер unknown, С. 103609 - 103609

Опубликована: Март 1, 2025

In HER2+ breast cancer (BC), neoadjuvant therapy represents an ideal scenario for translational research, considering pathological complete response (pCR) as endpoint. these patients, achieving pCR after is associated with a better prognosis. However, biomarkers are needed to tailor optimal treatment each patient. Evaluating tumour-infiltrating lymphocytes (TILs) has gained attention in predicting pCR. the context of metastatic disease, TILs also appear play role outcomes. The interaction between presence and reactive oxygen species (ROS) remains area be explored. ROS critical tumour cell homeostasis, different levels can trigger differential biological responses cells their microenvironment. Nevertheless, influence on efficacy prognosis patients BC elucidated. this article, we reviewed interplay response, immune system activation, production suggested novel areas intervention research. We present bioinformatic analysis demonstrating that altered expression several redox-related genes could prevalence populations microenvironment patient survival. New thus should further explored best

Язык: Английский

Процитировано

0
Engineered Nanovesicles for the Precise and Noninvasive Treatment of Deep Osteomyelitis Caused by MRSA Infection with Enhanced Immune Response DOI

Xingyue Yang,

Ren Fang,

Xiaotian Li

и другие.

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Фев. 13, 2025

The clinical treatment of hospital-acquired persistent osteomyelitis caused by methicillin-resistant Staphylococcus aureus (MRSA) presents two major challenges: ineffective drug delivery into deep tissues and counteracting the rapid establishment an immunosuppressive microenvironment. Indeed, MRSA can evade immunosurveillance undermine both innate adaptive immune responses. Herein, engineered nanovesicles, functioning combining sonodynamic therapy (SDT) with modulation, were constructed for precise noninvasive removal in tissue activation antimicrobial response using a newly nanovesicle. Macrophage-derived M1 phenotypic microvesicles (M1-MW) internalized vancomycin-cross-linked micelles acoustic sensitizer indocyanine green (ICG) (VCG micelles). vesicles M1-MW grafted PEGylated mannose, allowing targeted accumulation at infection site. VCG responsive to highly reducing environment released ICG generate ROS after exposure ultrasounds. This effect was combined presence vancomycin kill MRSA. In model, we observed improved survival rate reprogramming macrophages pro-inflammatory phenotype. latter promoted T-cell defense against MRSA-camouflaged homologous cell-transferred infections. Thus, our study efficient (VCG@MMW) bacterial clearance reduced risk recurrence enhanced response.

Язык: Английский

Процитировано

0
Antibacterial TiO2 nanoparticles and hydroxyapatite loaded carboxymethyl cellulose bio-nanocomposite scaffold for wound dressing application DOI
Qiong Wang, Mahani Yusoff, Nozieana Khairuddin

и другие.

Materials Chemistry and Physics, Год журнала: 2025, Номер unknown, С. 130835 - 130835

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Paraptosis—A Distinct Pathway to Cell Death DOI Open Access

C Kunst,

Deniz Tümen,

Martha Ernst

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(21), С. 11478 - 11478

Опубликована: Окт. 25, 2024

Cell death is a critical biological process necessary for development, tissue maintenance, and defense against diseases. To date, more than 20 forms of cell have been identified, each defined by unique molecular pathways. Understanding these different essential investigating the pathogenesis diseases such as cancer, neurodegenerative disorders, autoimmune conditions developing appropriate therapies. Paraptosis distinct form regulated characterized cytoplasmic vacuolation dilatation cellular organelles like mitochondria endoplasmic reticulum (ER). It several signaling pathways, instance, those associated with ER stress, calcium overload, oxidative specific cascades insulin-like growth factor I receptor (IGF-IR) its downstream pathways comprising mitogen-activated protein kinases (MAPKs) Jun N-terminal kinase (JNK). has observed in diverse contexts, including development stress responses neuronal, retinal, endothelial, muscle cells. The induction paraptosis increasingly important anticancer therapy, it targets non-apoptotic tumor cells, which can be utilized to induce death. This approach enhances treatment efficacy addresses drug resistance, particularly cases where cancer cells are resistant apoptosis. Combining paraptosis-inducing agents traditional therapies holds promise enhancing overcoming suggesting valuable strategy therapy.

Язык: Английский

Процитировано

1
Enhanced ROS Production and Mitochondrial Metabolic Shifts in CD4+ T Cells of an Autoimmune Uveitis Model DOI Open Access

Ronja Söth,

Anne Lisbeth Hoffmann,

Cornelia A. Deeg

и другие.

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(21), С. 11513 - 11513

Опубликована: Окт. 26, 2024

Equine recurrent uveitis (ERU) is a spontaneously occurring autoimmune disease and one of the leading causes blindness in horses worldwide. Its similarities to autoimmune-mediated humans make it unique spontaneous animal model for this disease. Although many aspects ERU pathogenesis have been elucidated, remains not fully understood requires further research. CD4+ T cells particular focus In previous study, we showed metabolic alterations from cases, including an increased basal oxygen consumption rate (OCR) elevated compensatory glycolysis. To investigate underlying reasons consequences these changes, quantified reactive species (ROS) production cases compared healthy controls, revealing significantly higher ROS ERU-affected horses. Additionally, aimed define mitochondrial fuel oxidation glucose, glutamine, long-chain fatty acids (LCFAs) identified significant differences between controls. lower dependency on glucose greater flexibility LCFAs, indicating enhanced ability switch alternative fuels when necessary.

Язык: Английский

Процитировано

1
MDSC: a new potential breakthrough in CAR-T therapy for solid tumors DOI Creative Commons

Nada Mohamady Farouk Abdalsalam,

Abdulrahman Ibrahim,

Muhammad Auwal Saliu

и другие.

Cell Communication and Signaling, Год журнала: 2024, Номер 22(1)

Опубликована: Дек. 19, 2024

Chimeric antigen receptor T (CAR-T) cell therapy has shown remarkable success in hematologic malignancies but encountered challenges effectively treating solid tumors. One major obstacle is the presence of immunosuppressive tumor microenvironment (TME), which mainly built by myeloid-derived suppressor cells (MDSCs). Recent studies have that MDSCs a detrimental effect on CAR-T due to their potent capabilities. Targeting promising results enhance immunotherapy preclinical models. In this review, we first highlight increase proliferation, transition, angiogenesis and encourage circulating (CTCs) extravasation leading progression metastasis. Moreover, describe main characteristics activities TME. Most importantly, summarize targeting therapeutic strategies therapies against These include (1) through small molecule inhibitors large antibodies; (2) cancer combination with MDSC modulatory agents; (3) cytokine antigen-targeted indirectly or directly reshapes TME; (4) modified natural killer (NK) expressing activating MDSCs; (5) selective antigens. near future, are expected witness improvement for tumors clinical practice.

Язык: Английский

Процитировано

1