Single-cell dual-omics reveals translational and transcriptional landscapes and regulations in oocytes from ovarian endometriosis patients
Frontiers in Endocrinology,
Год журнала:
2025,
Номер
16
Опубликована: Фев. 17, 2025
A
significant
proportion
of
women
in
their
reproductive
years
are
afflicted
by
endometriosis.
And
one
the
major
contributing
factors
to
infertility
linked
ovarian
endometriosis
is
thought
be
oocyte
quality.
The
precise
molecular
mechanisms
still
unknown.
Furthermore,
because
transcriptional
silence,
translatome
better
able
explain
behavior
oocytes
than
transcriptome
sequencing,
which
has
been
used
widely
recent
years.
We
conducted
single-cell
and
sequencing
on
obtained
from
patients
with
endometriosis,
as
well
control
subjects
due
tubal
or
male
factors.
For
first
time,
we
characterized
translational
profiles
mRNA
GV-stage
subjects.
Our
analysis
identified
2,480
differentially
expressed
genes
patients.
demonstrated
that
global
activity
human
significantly
altered
Key
pathways
such
"oxidative
stress,"
"oocyte
meiosis,"
"spliceosome"
were
critical
influencing
quality
This
study
elucidated
characteristics
potential
underlying
poor
findings
provided
new
insights
into
pathogenesis
endometriosis-associated
highlighted
therapeutic
targets
for
improving
outcomes.
Язык: Английский
Endometriosis: A New Perspective on Epigenetics and Oxidative Stress
Journal of Reproductive Immunology,
Год журнала:
2025,
Номер
169, С. 104462 - 104462
Опубликована: Фев. 21, 2025
Язык: Английский
Global, Regional and National Burden of Infertility due to Endometriosis: Results From the Global Burden of Disease Study 2021 and Forecast to 2044
BJOG An International Journal of Obstetrics & Gynaecology,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 25, 2025
ABSTRACT
Objective
To
analyse
global
prevalence
data
for
infertility
due
to
endometriosis
from
1990
2021,
emphasising
health
inequalities.
Design
Population‐based
study.
Setting
Data
the
Global
Burden
of
Disease
(GBD)
database.
Population
Individuals
diagnosed
with
endometriosis.
Methods
A
statistical
method
was
employed
evaluate
changes
in
disease
over
time.
We
also
analysed
how
varies
by
age,
time
period
and
birth
cohort.
model
used
predict
future
trends.
Additionally,
we
examined
relationship
between
socio‐demographic
index
(SDI)
levels
across
countries.
Finally,
conducted
a
decomposition
analysis
identify
key
factors
driving
assessed
inequality.
Main
Outcome
Measures
The
burden
Results
2021
showed
downward
trend,
low
SDI
region
had
notably
higher
burden.
High
risk
observed
25–29
age
group
effects
analysis.
Period
risks
almost
kept
decreasing
these
years,
cohort
effects,
later
born
individuals
an
overall
lower
than
earlier
individuals.
Cross‐country
inequality
revealed
significant
disparities,
countries
categories
bearing
Conclusions
has
become
public
concern
recent
decades.
Governments
should
adapt
prevention
strategies
fit
their
specific
national
contexts.
Язык: Английский
Oxidative stress, ferroptosis, somatic mutations, antioxidant therapy, and endometriosis: a new perspective on the issue
Russian Journal of Human Reproduction,
Год журнала:
2024,
Номер
30(6), С. 32 - 32
Опубликована: Янв. 1, 2024
Язык: Английский
Advances in research on malignant transformation of endometriosis-associated ovarian cancer
Frontiers in Oncology,
Год журнала:
2024,
Номер
14
Опубликована: Окт. 9, 2024
Endometriosis
(EMs)
is
a
prevalent
chronic
gynecological
condition
that
depends
on
estrogen,
marked
by
the
presence
of
active
endometrial
tissue
(glands
and
stroma)
outside
uterus.
Although
pathologically
benign,
it
exhibits
biological
behaviors
such
as
invasion
metastasis
akin
to
malignant
tumors.
Endometriosis-associated
ovarian
carcinoma
(EAOC),
arising
from
transformation
EMs,
poses
significant
clinical
challenges.
However,
mechanisms
underlying
EAOC
pathogenesis
remain
incompletely
understood,
with
lack
reliable
biomarkers
for
early
diagnosis
personalized
treatment
strategies.
Considering
number
EMs
patients
extended
period
during
which
can
occur,
deserves
attention.
Current
research
both
domestically
internationally
indicates
complex,
involving
genetic
mutations,
immune
microenvironment,
oxidative
stress,
epigenetic
changes,
related
areas.
This
review
summarizes
development
EAOC.
Язык: Английский
The Global, Regional, and National Burden of Infertility Due to Endometriosis in Women of Childbearing Age, 1990-2021: Results from the Global Burden of Disease Study 2021 and Forecast to 2044
Опубликована: Янв. 1, 2024
Язык: Английский
N6-methyladenosine methylation regulators can serve as potential biomarkers for endometriosis related infertility
Biomolecules and Biomedicine,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 25, 2024
Endometriosis
(EMS)
is
a
chronic
inflammatory
disease
frequently
associated
with
infertility.
N6-methyladenosine
(m6A)
methylation,
the
most
common
form
of
methylation
in
eukaryotic
mRNAs,
has
gained
attention
study
female
reproductive
diseases,
including
EMS
and
This
aimed
to
investigate
role
m6A
regulators
EMS-related
To
begin,
specific
were
identified
by
analyzing
GSE120103
dataset,
followed
receiver
operating
characteristic
(ROC)
curve
analysis.
A
nomogram
model
was
then
constructed,
unsupervised
clustering
performed
identify
distinct
molecular
clusters.
Functional
enrichment
analysis
differentially
expressed
genes
(DEGs)
between
these
clusters,
along
immune
cell
infiltration
analysis,
subsequently
conducted.
In
addition,
single-cell
dataset
GSE214411
analyzed
explore
various
types.
Finally,
clinical
samples
collected,
immunohistochemistry
performed.
The
seven
key
significant
diagnostic
value
for
infertility
two
Gene
Ontology
(GO)
Kyoto
Encyclopedia
Genes
Genomes
(KEGG)
analyses
DEGs
clusters
revealed
that
strongly
pathways.
Immune
further
demonstrated
expression
levels
had
notable
impact
on
infiltration.
Single-cell
HNRNPA2B1
HNRNPC
significantly
elevated
endometrial
cells
from
infertile
patients
but
notably
decreased
stromal
cells.
Immunohistochemical
staining
confirmed
higher
eutopic
endometrium
fertile
women
compared
ovarian
patients.
These
findings
suggest
play
critical
roles
development
progression
Notably,
may
serve
as
potential
biomarkers
this
condition.
Язык: Английский