N6-methyladenosine methylation regulators can serve as potential biomarkers for endometriosis related infertility DOI Creative Commons

Yalun He,

Jie Ding,

Tonglin Bai

et al.

Biomolecules and Biomedicine, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 25, 2024

Endometriosis (EMS) is a chronic inflammatory disease frequently associated with infertility. N6-methyladenosine (m6A) methylation, the most common form of methylation in eukaryotic mRNAs, has gained attention study female reproductive diseases, including EMS and This aimed to investigate role m6A regulators EMS-related To begin, specific were identified by analyzing GSE120103 dataset, followed receiver operating characteristic (ROC) curve analysis. A nomogram model was then constructed, unsupervised clustering performed identify distinct molecular clusters. Functional enrichment analysis differentially expressed genes (DEGs) between these clusters, along immune cell infiltration analysis, subsequently conducted. In addition, single-cell dataset GSE214411 analyzed explore various types. Finally, clinical samples collected, immunohistochemistry performed. The seven key significant diagnostic value for infertility two Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) analyses DEGs clusters revealed that strongly pathways. Immune further demonstrated expression levels had notable impact on infiltration. Single-cell HNRNPA2B1 HNRNPC significantly elevated endometrial cells from infertile patients but notably decreased stromal cells. Immunohistochemical staining confirmed higher eutopic endometrium fertile women compared ovarian patients. These findings suggest play critical roles development progression Notably, may serve as potential biomarkers this condition.

Language: Английский

Single-cell dual-omics reveals translational and transcriptional landscapes and regulations in oocytes from ovarian endometriosis patients DOI Creative Commons

X Diao,

Jiana Huang, Rui Xiang

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 17, 2025

A significant proportion of women in their reproductive years are afflicted by endometriosis. And one the major contributing factors to infertility linked ovarian endometriosis is thought be oocyte quality. The precise molecular mechanisms still unknown. Furthermore, because transcriptional silence, translatome better able explain behavior oocytes than transcriptome sequencing, which has been used widely recent years. We conducted single-cell and sequencing on obtained from patients with endometriosis, as well control subjects due tubal or male factors. For first time, we characterized translational profiles mRNA GV-stage subjects. Our analysis identified 2,480 differentially expressed genes patients. demonstrated that global activity human significantly altered Key pathways such "oxidative stress," "oocyte meiosis," "spliceosome" were critical influencing quality This study elucidated characteristics potential underlying poor findings provided new insights into pathogenesis endometriosis-associated highlighted therapeutic targets for improving outcomes.

Language: Английский

Citations

0
Endometriosis: A New Perspective on Epigenetics and Oxidative Stress DOI
Yu Guan, Ya‐Wen Chen,

Rong Lin

et al.

Journal of Reproductive Immunology, Journal Year: 2025, Volume and Issue: 169, P. 104462 - 104462

Published: Feb. 21, 2025

Language: Английский

Citations

0
Global, Regional and National Burden of Infertility due to Endometriosis: Results From the Global Burden of Disease Study 2021 and Forecast to 2044 DOI
Yue Chen, Cheng Liu,

Xiuping Wang

et al.

BJOG An International Journal of Obstetrics & Gynaecology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

ABSTRACT Objective To analyse global prevalence data for infertility due to endometriosis from 1990 2021, emphasising health inequalities. Design Population‐based study. Setting Data the Global Burden of Disease (GBD) database. Population Individuals diagnosed with endometriosis. Methods A statistical method was employed evaluate changes in disease over time. We also analysed how varies by age, time period and birth cohort. model used predict future trends. Additionally, we examined relationship between socio‐demographic index (SDI) levels across countries. Finally, conducted a decomposition analysis identify key factors driving assessed inequality. Main Outcome Measures The burden Results 2021 showed downward trend, low SDI region had notably higher burden. High risk observed 25–29 age group effects analysis. Period risks almost kept decreasing these years, cohort effects, later born individuals an overall lower than earlier individuals. Cross‐country inequality revealed significant disparities, countries categories bearing Conclusions has become public concern recent decades. Governments should adapt prevention strategies fit their specific national contexts.

Language: Английский

Citations

0
Oxidative stress, ferroptosis, somatic mutations, antioxidant therapy, and endometriosis: a new perspective on the issue DOI
L.V. Adamyan, L.G. Pivazyan, K.S. Kurbatova

et al.

Russian Journal of Human Reproduction, Journal Year: 2024, Volume and Issue: 30(6), P. 32 - 32

Published: Jan. 1, 2024

Language: Английский

Citations

0
Advances in research on malignant transformation of endometriosis-associated ovarian cancer DOI Creative Commons
Fang Chen,

Mengying Zhu,

Wenjuan Li

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: Oct. 9, 2024

Endometriosis (EMs) is a prevalent chronic gynecological condition that depends on estrogen, marked by the presence of active endometrial tissue (glands and stroma) outside uterus. Although pathologically benign, it exhibits biological behaviors such as invasion metastasis akin to malignant tumors. Endometriosis-associated ovarian carcinoma (EAOC), arising from transformation EMs, poses significant clinical challenges. However, mechanisms underlying EAOC pathogenesis remain incompletely understood, with lack reliable biomarkers for early diagnosis personalized treatment strategies. Considering number EMs patients extended period during which can occur, deserves attention. Current research both domestically internationally indicates complex, involving genetic mutations, immune microenvironment, oxidative stress, epigenetic changes, related areas. This review summarizes development EAOC.

Language: Английский

Citations

0
The Global, Regional, and National Burden of Infertility Due to Endometriosis in Women of Childbearing Age, 1990-2021: Results from the Global Burden of Disease Study 2021 and Forecast to 2044 DOI
Yue Chen,

Xiuping Wang,

Yi Liu

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0
N6-methyladenosine methylation regulators can serve as potential biomarkers for endometriosis related infertility DOI Creative Commons

Yalun He,

Jie Ding,

Tonglin Bai

et al.

Biomolecules and Biomedicine, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 25, 2024

Endometriosis (EMS) is a chronic inflammatory disease frequently associated with infertility. N6-methyladenosine (m6A) methylation, the most common form of methylation in eukaryotic mRNAs, has gained attention study female reproductive diseases, including EMS and This aimed to investigate role m6A regulators EMS-related To begin, specific were identified by analyzing GSE120103 dataset, followed receiver operating characteristic (ROC) curve analysis. A nomogram model was then constructed, unsupervised clustering performed identify distinct molecular clusters. Functional enrichment analysis differentially expressed genes (DEGs) between these clusters, along immune cell infiltration analysis, subsequently conducted. In addition, single-cell dataset GSE214411 analyzed explore various types. Finally, clinical samples collected, immunohistochemistry performed. The seven key significant diagnostic value for infertility two Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) analyses DEGs clusters revealed that strongly pathways. Immune further demonstrated expression levels had notable impact on infiltration. Single-cell HNRNPA2B1 HNRNPC significantly elevated endometrial cells from infertile patients but notably decreased stromal cells. Immunohistochemical staining confirmed higher eutopic endometrium fertile women compared ovarian patients. These findings suggest play critical roles development progression Notably, may serve as potential biomarkers this condition.

Language: Английский

Citations

0