Anti-Aging Effects of Flavonoids from Plant Extracts
Foods,
Год журнала:
2024,
Номер
13(15), С. 2441 - 2441
Опубликована: Авг. 2, 2024
Aging
is
a
natural
and
irreversible
process,
affecting
living
organisms
by
negatively
impacting
the
tissues'
cells'
morphology
functionality
consequently
being
responsible
for
aging-related
diseases.
Taking
into
account
actual
preoccupations
of
both
consumers
researchers,
healthy
anti-aging
alternatives
are
intensively
studied
in
order
to
address
such
concerns.
Due
their
functional
features,
plant
flavonoids
can
be
considered
valuable
nutraceuticals.
This
paper
highlights
possibilities
use
extracted
from
various
plants
potential
on
skin,
brain,
heart.
Moreover,
anticarcinogenic,
anti-inflammatory,
anti-diabetic
properties
summarized,
along
with
senescence-associated
mechanisms.
Both
nutraceutical
cosmeceutical
fields
continuously
developing
originating
promising
candidates
obtain
products.
Thus,
bioactive
compounds'
extraction
subsequent
involvement
innovative
product
manufacturing
must
carefully
performed
while
aware
intrinsic
extrinsic
factors
that
may
affect
phytochemicals'
structures,
bioavailability,
health
effects.
Язык: Английский
The Anti-Aging Mechanism of Metformin: From Molecular Insights to Clinical Applications
Molecules,
Год журнала:
2025,
Номер
30(4), С. 816 - 816
Опубликована: Фев. 10, 2025
Aging
represents
a
complex
biological
phenomenon
marked
by
the
progressive
deterioration
of
physiological
functions
over
time,
reduced
resilience,
and
increased
vulnerability
to
age-related
diseases,
ultimately
culminating
in
mortality.
Recent
research
has
uncovered
diverse
molecular
mechanisms
through
which
metformin
extends
its
benefits
beyond
glycemic
control,
presenting
it
as
promising
intervention
against
aging.
This
review
delves
into
anti-aging
properties
metformin,
highlighting
role
mitochondrial
energy
modulation,
activation
AMPK-mTOR
signaling
pathway,
stimulation
autophagy,
mitigation
inflammation
linked
cellular
Furthermore,
we
discuss
influence
on
epigenetic
modifications
that
underpin
genomic
stability
homeostasis.
Metformin's
potential
addressing
age-associated
disorders
including
metabolic,
cardiovascular,
neurodegenerative
diseases
is
also
explored.
The
Targeting
with
Metformin
(TAME)
trial
aims
provide
key
evidence
efficacy
delaying
aging
humans.
Despite
these
insights,
significant
challenges
persist
gaining
more
comprehensive
understanding
underlying
mechanisms,
determining
optimal
dosing
strategies,
evaluating
long-term
safety
non-diabetic
populations.
Addressing
crucial
fully
realizing
metformin's
an
therapeutic.
Язык: Английский
Jianpi Qingre Tongluo prescription alleviates the senescence-associated secretory phenotype with osteoarthritis by regulating STAG1/TP53/P21 signaling pathway
Journal of Ethnopharmacology,
Год журнала:
2024,
Номер
unknown, С. 118953 - 118953
Опубликована: Окт. 1, 2024
Язык: Английский
A 7T MRI Study of Fibular Bone Thickness and Density: Impact of Age, Sex and Body Weight, and Correlation with Bone Marrow Expansion and Muscle Fat Infiltration
Diagnostics,
Год журнала:
2025,
Номер
15(5), С. 564 - 564
Опубликована: Фев. 26, 2025
Background:
Reduced
bone
mass
and
density,
hallmark
features
of
osteopenia
osteoporosis,
significantly
increase
the
risk
fractures,
falls,
loss
mobility,
especially
in
post-menopausal
women
elderly.
Methods:
This
quantitative
7T
MRI
study
examines
fibular
thinning
mineral
density
(BMD)
107
individuals
(43F/64M)
across
various
ages,
body
indices
(BMIs),
ethnicities.
Results:
Women
had
lower
cross-sectional
wall
thickness
(BT)
tissue
area
(BA),
along
with
greater
BMD
compared
to
men
those
over
age
50
(n
=
77),
but
not
younger
group
30).
The
g-factor,
defined
as
ratio
inner-to-outer
diameters,
increased
thinning,
marrow
expansion
(BME),
muscle
fat
infiltration
(MFI)
was
independent
subcutaneous
(SFT).
Bone
both
tend
BME
MFI.
Additionally,
decrease
correlated
loss,
a
stronger
association
observed
BT
than
BA.
Conclusions:
These
findings
offer
insights
into
effects
aging
sex
on
skeletomuscular
health,
implications
for
strategies
mitigate
osteoporosis
osteosarcopenia.
Язык: Английский
Connecting the dots: sex, depression, and musculoskeletal health
Journal of Clinical Investigation,
Год журнала:
2024,
Номер
134(18)
Опубликована: Сен. 16, 2024
Depression
and
multiple
musculoskeletal
disorders
are
overrepresented
in
women
compared
with
men.
Given
that
depression
is
a
modifiable
risk
factor
improvement
of
depressive
symptoms
increases
positive
outcomes
following
orthopedic
intervention,
efforts
to
improve
clinical
recognition
increased
action
toward
ameliorating
among
patients
positioned
reduce
complications
positively
affect
patient-reported
outcomes.
Although
psychosocial
factors
play
role
the
manifestation
remittance
depression,
it
also
well
appreciated
primary
biochemical
changes
capable
causing
perpetuating
depression.
Unique
insight
for
novel
treatments
may
be
facilitated
by
query
bidirectional
relationship
between
health
This
Review
aims
synthesize
diverse
literature
on
sex,
orthopedics
emphasize
potential
common
underlying
biological
substrates.
overrepresentation
women,
emphasis
drivers
co-occurrence
these
women's
health.
Язык: Английский
Gene expression and hormonal signaling in osteoporosis: from molecular mechanisms to clinical breakthroughs
Journal of Biomaterials Science Polymer Edition,
Год журнала:
2024,
Номер
unknown, С. 1 - 36
Опубликована: Дек. 27, 2024
Osteoporosis
is
well
noted
to
be
a
universal
ailment
that
realization
impaired
bone
mass
and
micro
architectural
deterioration
thus
enhancing
the
probability
of
fracture.
Despite
its
high
incidence,
management
remains
highly
demanding
because
multifactorial
pathophysiology
disease.
This
review
highlights
recent
findings
in
osteoporosis
particularly,
gene
expression
hormonal
control.
Some
newest
approaches
regarding
subject
are
described,
including
single-cell
RNA
sequencing
long
non-coding
RNAs.
Also,
reflects
new
on
signaling
estrogen
parathyroid
hormone;
patient-specific
due
genetic
variation.
Potential
biomarkers
AI
comprised
as
factors
for
improving
ability
anticipate
manage
fractures.
These
hold
great
potential
drugs,
combination
therapies
based
future.
Further
studies
cooperation
scientists
clinicians
will
help
apply
such
novelties
into
practical
uses
sphere
medicine
order
enhance
treatment
patients
with
osteoporosis.
Язык: Английский