Modulation of the Neuro–Cancer Connection by Metabolites of Gut Microbiota

Biomolecules, Journal Year: 2025, Volume and Issue: 15(2), P. 270 - 270

Published: Feb. 12, 2025

The gut-brain-cancer axis represents a novel and intricate connection between the gut microbiota, neurobiology, cancer progression. Recent advances have accentuated significant role of microbiota metabolites in modulating systemic processes that influence both brain health tumorigenesis. This paper explores emerging concept metabolite-mediated modulation within connection, focusing on key such as short-chain fatty acids (SCFAs), tryptophan derivatives, secondary bile acids, lipopolysaccharides (LPS). While microbiota's impact immune regulation, neuroinflammation, tumor development is well established, gaps remain grasping how specific contribute to neuro-cancer interactions. We discuss with potential implications for neurobiology cancer, indoles polyamines, which yet be extensively studied. Furthermore, we review preclinical clinical evidence linking dysbiosis, altered metabolite profiles, tumors, showcasing limitations research gaps, particularly human longitudinal studies. Case studies investigating microbiota-based interventions, including dietary changes, fecal transplantation, probiotics, demonstrate promise but also indicate hurdles translating these findings therapies. concludes call standardized multi-omics approaches bi-directional frameworks integrating microbiome, neuroscience, oncology develop personalized therapeutic strategies patients.

Language: Английский

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Could a Mediterranean Diet Modulate Alzheimer’s Disease Progression? The Role of Gut Microbiota and Metabolite Signatures in Neurodegeneration

Foods, Journal Year: 2025, Volume and Issue: 14(9), P. 1559 - 1559

Published: April 29, 2025

Neurodegenerative disorders such as Alzheimer's disease (AD), the most common form of dementia, represent a growing global health crisis, yet current treatment strategies remain primarily palliative. Recent studies have shown that neurodegeneration through complex interactions within gut-brain axis largely depends on gut microbiota and its metabolites. This review explores intricate molecular mechanisms linking dysbiosis to cognitive decline, emphasizing impact microbial metabolites, including short-chain fatty acids (SCFAs), bile acids, tryptophan neuroinflammation, blood-brain barrier (BBB) integrity, amyloid-β tau pathology. The paper highlights major microbiome signatures associated with disease, detailing their metabolic pathways inflammatory crosstalk. Dietary interventions promise in modulating composition, potentially mitigating neurodegenerative processes. critically examines influence dietary patterns, Mediterranean Western diets, microbiota-mediated neuroprotection. Bioactive compounds like prebiotics, omega-3 polyphenols exhibit neuroprotective effects by reducing neuroinflammation. Furthermore, it discusses emerging microbiome-based therapeutic strategies, probiotics, postbiotics, fecal transplantation (FMT), potential for slowing progression. Despite these advances, several knowledge gaps remain, interindividual variability responses need large-scale, longitudinal studies. study proposes an integrative, precision medicine approach, incorporating science into paradigms. Ultimately, cognizance at mechanistic level could unlock novel avenues, offering non-invasive, diet-based strategy managing improving health.

Language: Английский

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Decoding Neurodegeneration: A Review of Molecular Mechanisms and Therapeutic Advances in Alzheimer’s, Parkinson’s, and ALS

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12613 - 12613

Published: Nov. 24, 2024

Neurodegenerative diseases, such as Alzheimer's, Parkinson's, ALS, and Huntington's, remain formidable challenges in medicine, with their relentless progression limited therapeutic options. These diseases arise from a web of molecular disturbances-misfolded proteins, chronic neuroinflammation, mitochondrial dysfunction, genetic mutations-that slowly dismantle neuronal integrity. Yet, recent scientific breakthroughs are opening new paths to intervene these once-intractable conditions. This review synthesizes the latest insights into underlying dynamics neurodegeneration, revealing how intertwined pathways drive course diseases. With an eye on most promising advances, we explore innovative therapies emerging cutting-edge research: nanotechnology-based drug delivery systems capable navigating blood-brain barrier, gene-editing tools like CRISPR designed correct harmful variants, stem cell strategies that not only replace lost neurons but foster neuroprotective environments. Pharmacogenomics is reshaping treatment personalization, enabling tailored align individual profiles, while diagnostics biomarkers ushering era early, precise disease detection. Furthermore, novel perspectives gut-brain axis sparking interest mounting evidence suggests microbiome modulation may play role reducing neuroinflammatory responses linked neurodegenerative progression. Taken together, advances signal shift toward comprehensive, personalized approach could transform care. By integrating techniques, this offers forward-looking perspective future where treatments aim just manage symptoms fundamentally alter progression, presenting renewed hope for improved patient outcomes.

Language: Английский

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Brain Glycogen—Its Metabolic Role in Neuronal Health and Neurological Disorders—An Extensive Narrative Review

Metabolites, Journal Year: 2025, Volume and Issue: 15(2), P. 128 - 128

Published: Feb. 13, 2025

Background: Brain glycogen is imperative for neuronal health, as it supports energy demands and metabolic processes. This review examines the pathways involved in storage utilization central nervous system, emphasizing their role both physiology pathology. It explores how alterations metabolism contribute to neurological disorders, including neurodegenerative diseases, epilepsy, conditions while highlighting bidirectional interaction between neurons glia maintaining brain homeostasis. Methods: A comprehensive search of articles published 2015 2025 was conducted using following databases: ScienceDirect, Scopus, Wiley, Web Science, Medline, PubMed. The selection relevant studies based on focus its conditions, with that did not meet inclusion criteria being excluded. Results: processes are subject rigorous regulation by astrocyte-neuron interactions, thereby ensuring homeostasis availability. dysregulation mobilization has been implicated development synaptic dysfunction, excitotoxicity, neurodegeneration a variety disorders. For instance, aberrant accumulation diseases such Lafora disease associated severe neurodegeneration, impaired shown exacerbate deficits Alzheimer's epilepsy. Conclusions: Targeting represents promising approach therapeutic intervention However, translation these strategies human models remains challenging, particularly regard long-term safety specificity glycogen-targeted therapies.

Language: Английский

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Role of the Intestinal Microbiota in the Molecular Pathogenesis of Atypical Parkinsonian Syndromes

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 3928 - 3928

Published: April 22, 2025

The role of the intestinal microbiota and its influence on neurodegenerative disorders has recently been extensively explored, especially in context Parkinson’s disease (PD). In particular, immunomodulation, impact inflammation, participation gut–brain axis are under ongoing investigations. Recent studies have revealed new data that could be important for exploring neurodegeneration mechanisms connected with gut microbiota, potentially leading to development methods treatment. this review, potential roles future disease-modifying therapies were discussed properties microbiota—including impacts metabolism short-chain fatty acids vitamins—were summarized, a particular focus atypical Parkinsonian syndromes. This review focused detailed description numerous through which influences processes. explored connections between evolution progression Finally, derived results regarding alterations syndromes comparison previously described PD was also included.

Language: Английский

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Human Gut Microbiome: A Connecting Organ Between Nutrition, Metabolism, and Health

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4112 - 4112

Published: April 26, 2025

The gut microbiome plays a vital role in human health, functioning as metabolic organ that influences nutrient absorption and overall well-being. With growing evidence dietary interventions can modulate the improve this review examines whether healthcare systems should prioritize personalized microbiome-targeted therapies, such probiotics, prebiotics, microbiota transplants, over traditional pharmaceutical treatments for chronic diseases like obesity, diabetes, cardiovascular risk, inflammatory conditions. A systematic using Web of Science Scopus databases was conducted, followed by scientometric analysis. Key pathways, fiber fermentation short-chain fatty acid production, were explored, focusing on their impact lipid glucose metabolism. interactions between microbial metabolites immune system also investigated. Dietary interventions, including increased probiotic intake, show potential addressing dysbiosis linked to conditions, type 2 autoimmune diseases. emphasizes need incorporate modulation strategies into clinical practice research, calling multidisciplinary approach integrates nutrition, microbiology, biochemistry better understand microbiome's complex health.

Language: Английский

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