Flaxseed Oil Mitigates Stress-Induced Immunoreactivity Loss of Midbrain Tyrosine Hydroxylase-Positive neurons caused by High- intensity exercise training DOI
Rodrigo F. Oliveira, Karina Maia Paiva,

Antônio Vicente Dias de Andrade

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: May 16, 2025

Abstract Exercise training exerts complex effects on brain plasticity, particularly in dopaminergic midbrain regions, yet its interaction with neuroprotective compounds remains underexplored. Plant-derived omega-3 fatty acids, such as alpha-linolenic acid flaxseed oil, possess antioxidant and properties, that may buffer exercise-induced stress neuron-glia dynamics. This study evaluated the of oil supplementation morphology, density, protein expression neurons astrocytes under high-intensity exercise conditions. Male Wistar rats were assigned to four groups: sedentary (CN), (OLSE), (EX), (OLEX). Mesencephalic tissue was analyzed by immunohistochemistry for tyrosine hydroxylase (TH), glial fibrillary acidic (GFAP), calbindin, assessing morphological changes, optical cell density. Morphometric analysis revealed significant increases TH + neuronal soma area perimeter OLEX group compared EX CN (p < 0.05), without changes observed ventral tegmental (VTA) neurons. The density GFAP similar across groups; however, showed differences TH, GFAP, calbindin between EX. These findings suggest alters morphology a region-specific manner. highlights potential bioactive compound preserving integrity, offering new insights into therapeutic applications neuroprotection physiological stress, potentially mitigating regions.

Language: Английский

Desenvolvimento sustentável e exercício físico: uma revisão integrativa DOI Open Access
Wellington Rui Andrade de Assis

Brazilian Journal of Health Review, Journal Year: 2025, Volume and Issue: 8(1), P. e76880 - e76880

Published: Jan. 17, 2025

Este estudo investiga a relação entre desenvolvimento sustentável e atividade física, ressaltando importância dos espaços públicos, como praças parques, para o bem-estar prática de exercícios. A crescente urbanização os desafios ambientais, agravados pelas mudanças climáticas, impactam saúde da população, resultando em aumento sobrepeso, obesidade doenças crônicas, especialmente grupos vulneráveis, crianças idosos. análise indica que disponibilidade áreas verdes está relacionada à redução violência ao evidenciando necessidade políticas públicas integradas considerem aspectos sociais, econômicos culturais. poluição do ar, material particulado, representa um problema sério afeta desproporcionalmente as populações exigindo intervenções melhorar qualidade ar acesso ambientes saudáveis. utilizou uma Revisão Integrativa Literatura, conforme fases metodológicas Souza et al. (2010), focando publicações 2022 2024. busca foi realizada nas bases dados Google Scholar, LILACS, MEDLINE, PubMed, Scielo ScienceDirect, 2.563.608 registros, quais 31 estudos foram selecionados. O manuscrito enfatiza públicos na promoção saúde, destacando sua correlação com física. Futuras pesquisas devem explorar interseção sustentabilidade incluindo baseadas natureza tecnologias, realidade virtual, promover hábitos saudáveis urbanos.

Citations

0
The Role of Astrocytes in the Temporoammonic Pathway: Masticatory Behavior as a Neuroprotective Strategy Against Age-Related Cognitive Decline DOI Creative Commons
Micaele Maria Lopes Castro, Fabio Leite do Amaral, Fernando Mendes

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Abstract Astrocytes undergo phenotypic changes with aging, contributing to neurodegenerative diseases and cognitive impairments in later life. The temporoammonic (TA) pathway terminates at the stratum lacunosum-moleculare (SLM) of CA1 region, where astrocytic support is crucial for synaptic plasticity information processing related spatial learning memory. This study tested hypothesis that age-related morphological astrocytes SLM affect performance we explored whether masticatory activity modulates these changes. Young (6 months) aged (18 female Swiss albino mice were subjected three distinct regimens: a hard diet (HD), HD followed by soft (HD/SD), or SD return (HD/SD/HD). Cognitive was assessed using Morris Water Maze (MWM), rates calculated from escape latencies throughout five days trials. After behavioral testing, culled immunohistochemical analysis glial fibrillary acidic protein (GFAP) expression performed. 3D reconstructions within generated analyzed. Hierarchical clustering identified astrocyte morphotypes, revealing significant shift high-complexity (AST1) toward lower-complexity subtypes (AST2 AST3. results demonstrate aging reduces complexity, especially dorsal which correlated impaired Notably, on HD/SD/HD regimen exhibited partial recovery function morphology, suggesting potential rehabilitation effect activity. Statistical confirmed differences complexity across age groups dietary regimens (p < 0.01). These findings highlight may contribute decline. Overall, maintaining proper mastication be an effective approach maintain integrity during preserve hippocampus-dependent function, particularly older individuals.

Language: Английский

Citations

0
Anthocyanins: From Natural Colorants to Potent Anticancer Agents DOI Creative Commons

Muhammad Maaz,

Muhammad Tauseef Sultan, Ahmad Mujtaba Noman

et al.

Food Science & Nutrition, Journal Year: 2025, Volume and Issue: 13(5)

Published: May 1, 2025

ABSTRACT Cancer is a prevalent global disease affecting ~20 million individuals, and this burden causes the death of ~9.7 people in 2024. The prevalence rate continuously increasing due to exposure harmful environmental occupational contaminants (toxins chemicals), compromised immune response, genetic modifications, poor lifestyle dietary practices. management cancer challenging demands cost‐effective safe therapeutic strategies. This review accentuates anticancer potential anthocyanins its associated underlying mechanism. Anthocyanins, active components extracted from grapes, berries, black chokeberries, eggplants, currants, sweet cherries, strawberries, plums, red onions, hold antioxidant anti‐inflammatory potential. bioavailability crucial factor imposing their effect, can be improved by microbial phenolic catabolites, provision α‐casein, nano delivery systems. Anthocyanins hinder cell migration, invasion, proliferation inducing apoptosis, suppressing cycle at G0/G1, S, or G2/M stages, modulating signaling pathways such as apoptotic cascades, PI3K/Akt, MAPK, NF‐κB. Moreover, downregulate oncogenes ( Bcl‐2 , MYC HER2 ) improve activity tumor suppressor genes TP53 BRCA1 RB1 ). particularly cyanidin‐3‐ O ‐glucoside, suppress inflammation production pro‐inflammatory cytokines (COX‐2, TNF‐α, IL‐6) colorectal hepatocellular carcinoma. it inhibition mitochondrial dysfunction ovarian cervical malignancies. Although pre‐clinical studies have proved activities, further clinical trials are required validate impact standard dose regimens.

Language: Английский

Citations

0
Flaxseed Oil Mitigates Stress-Induced Immunoreactivity Loss of Midbrain Tyrosine Hydroxylase-Positive neurons caused by High- intensity exercise training DOI
Rodrigo F. Oliveira, Karina Maia Paiva,

Antônio Vicente Dias de Andrade

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: May 16, 2025

Abstract Exercise training exerts complex effects on brain plasticity, particularly in dopaminergic midbrain regions, yet its interaction with neuroprotective compounds remains underexplored. Plant-derived omega-3 fatty acids, such as alpha-linolenic acid flaxseed oil, possess antioxidant and properties, that may buffer exercise-induced stress neuron-glia dynamics. This study evaluated the of oil supplementation morphology, density, protein expression neurons astrocytes under high-intensity exercise conditions. Male Wistar rats were assigned to four groups: sedentary (CN), (OLSE), (EX), (OLEX). Mesencephalic tissue was analyzed by immunohistochemistry for tyrosine hydroxylase (TH), glial fibrillary acidic (GFAP), calbindin, assessing morphological changes, optical cell density. Morphometric analysis revealed significant increases TH + neuronal soma area perimeter OLEX group compared EX CN (p < 0.05), without changes observed ventral tegmental (VTA) neurons. The density GFAP similar across groups; however, showed differences TH, GFAP, calbindin between EX. These findings suggest alters morphology a region-specific manner. highlights potential bioactive compound preserving integrity, offering new insights into therapeutic applications neuroprotection physiological stress, potentially mitigating regions.

Language: Английский

Citations

0