The clots removed from ischaemic stroke patients by mechanical thrombectomy are amyloid in nature DOI Creative Commons
Justine M. Grixti, Arun Chandran,

Johann Pretorius

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 4, 2024

Abstract Ischemic stroke due to large vessel occlusion results from the blockage of a major cerebral artery by clot; however, origins and molecular composition these clots remain poorly understood. Mechanical thrombectomy has become standard treatment remove obstructive clots, providing unique opportunity analyze their properties. We previously demonstrated that blood can clot into an amyloid-like form, generating fibrinaloid microclots (2–200 μm) are highly resistant fibrinolysis. In this study, archived eight ischemic patients with were examined, using samples stored in Walton Centre Clot Bank Liverpool, UK. All exhibited strong, heterogeneous amyloid staining, revealing pervasive component. These findings represent unreported characteristic highlighting potential for amyloid-targeted therapies overcome fibrinolytic resistance foundational new insight ischaemic pathophysiology treatment.

Язык: Английский

The clots removed from ischaemic stroke patients by mechanical thrombectomy are amyloid in nature DOI Creative Commons
Justine M. Grixti, Arun Chandran,

Johann Pretorius

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Ноя. 4, 2024

Abstract Ischemic stroke due to large vessel occlusion results from the blockage of a major cerebral artery by clot; however, origins and molecular composition these clots remain poorly understood. Mechanical thrombectomy has become standard treatment remove obstructive clots, providing unique opportunity analyze their properties. We previously demonstrated that blood can clot into an amyloid-like form, generating fibrinaloid microclots (2–200 μm) are highly resistant fibrinolysis. In this study, archived eight ischemic patients with were examined, using samples stored in Walton Centre Clot Bank Liverpool, UK. All exhibited strong, heterogeneous amyloid staining, revealing pervasive component. These findings represent unreported characteristic highlighting potential for amyloid-targeted therapies overcome fibrinolytic resistance foundational new insight ischaemic pathophysiology treatment.

Язык: Английский

Процитировано

1