Borderline in a linear city: Urban living brings borderline personality disorder to crisis through neuroplasticity—an urgent call to action
Frontiers in Psychiatry,
Год журнала:
2025,
Номер
15
Опубликована: Янв. 6, 2025
Borderline
in
a
linear
city:
Urban
living
is
bringing
borderline
personality
disorder
into
crisis
via
neuroplasticity-an
urgent
call
to
action
Provisionally
accepted
Язык: Английский
Walking and Hippocampal Formation Volume Changes: A Systematic Review
Brain Sciences,
Год журнала:
2025,
Номер
15(1), С. 52 - 52
Опубликована: Янв. 8, 2025
Sustaining
the
human
brain's
hippocampus
from
atrophy
throughout
ageing
is
critical.
Exercise
proven
to
be
effective
in
promoting
adaptive
hippocampal
plasticity,
and
has
a
bidirectional
relationship
with
physical
environment.
Therefore,
this
systematic
review
explores
effects
of
walking,
simple
activity
environment,
on
formation
volume
changes
for
lifelong
brain
cognitive
health.
PubMed,
Scopus,
Web
Science
were
searched
studies
humans
published
up
November
2022
examining
walking.
Twelve
met
inclusion
criteria.
Study
quality
was
assessed
using
PEDro
scale
ROBINS-I
tool.
A
narrative
synthesis
explored
walking
factors
associated
total,
subregional,
hemisphere-specific
changes.
Overall,
had
positive
volumes.
Several
found
benefits
higher-intensity
greater
amounts
total
volume.
The
subiculum
increased
after
low-intensity
nature
exposure,
while
parahippocampal
gyrus
benefited
vigorous
intensity.
right
spatial
navigation
during
No
examined
effect
dentate
gyrus.
This
highlights
as
multifaceted
variable
that
can
lead
manifold
These
findings
support
promotion
simple,
strategy
enhance
health
prevent
decline,
suggesting
design
environments
natural
biophilic
characteristics
layouts
walkability
stimulation.
Future
research
encouraged
explore
subregional
instead
focusing
volume,
since
multicompartmental
subfields
respond
differently
different
walking-related
variables.
Язык: Английский
Home Environment as a Therapeutic Target for Prevention and Treatment of Chronic Diseases: Delivering Restorative Living Spaces, Patient Education and Self-Care by Bridging Biophilic Design, E-Commerce and Digital Health Technologies
International Journal of Environmental Research and Public Health,
Год журнала:
2025,
Номер
22(2), С. 225 - 225
Опубликована: Фев. 5, 2025
A
high
prevalence
of
chronic
diseases
exposes
diverse
healthcare
pain
points
due
to
the
limited
effectiveness
pharmaceutical
drugs
and
biologics,
sedentary
lifestyles,
insufficient
health
literacy,
stress,
unsatisfactory
patient
experience,
environmental
pollution
competition
with
commercial
determinants
health.
To
improve
care
long-term
outcomes,
impact
home
environment
is
overlooked
underutilized
by
healthcare.
This
cross-disciplinary
work
describes
perspectives
on
(1)
as
a
therapeutic
target
for
prevention
treatment
(2)
transforming
health-centric
household
goods
e-commerce
platforms
into
digital
interventions.
We
provide
rationale
creating
environments
grounded
in
biophilic
design
(multisensory,
enrichment)
supporting
physical
activities,
quality
sleep,
nutrition,
music,
stress
reduction,
self-efficacy,
social
support
education,
hence
providing
clinical
benefits
through
modulation
autonomic
nervous
system,
neuroplasticity
behavior
change.
These
pleiotropic
"active
non-pharmacological
ingredients"
can
be
personalized
people
living
depression,
anxiety,
migraine,
pain,
cancer,
cardiovascular
other
conditions.
discuss
prospects
integrating
create
"therapeutic
environment"
interventions
delivered
therapeutics
their
combinations
prescription
drugs.
multimodal
approach
enhance
engagement
while
bridging
consumer
spending
outcomes.
Язык: Английский
Architecturally Mediated Allostasis and Neurosustainability: A Proposed Theoretical Framework for the Impact of the Built Environment on Neurocognitive Health
Brain Sciences,
Год журнала:
2025,
Номер
15(2), С. 201 - 201
Опубликована: Фев. 15, 2025
The
global
rise
in
mental
health-related
disorders
represents
a
significant
health
and
wellbeing
challenge,
imposing
substantial
social
economic
burden
on
individuals,
communities,
healthcare
systems.
According
to
the
World
Health
Organization,
one
four
people
globally
will
be
affected
by
or
neurological
at
some
point
their
lives,
highlighting
concern
that
warrants
carefully
considered
innovative
responses.
While
challenges
arise
from
complex,
multifaceted
factors,
emerging
research
indicates
built
environment-the
architecture
of
our
homes,
workplaces,
public
spaces-may
exert
critical
but
underappreciated
influence
outcomes.
This
paper
outlines
novel
theoretical
framework
for
how
visual
stressors
environment
might
trigger
neurophysiological
stress
responses
via
HPA
SAM
axes,
potentially
contributing
over
time
allostatic
load.
In
this
paper,
it
is
proposed
chronic
physiological
strain
can
alter
neuroplastic
processes
neurogenesis
key
brain
regions-such
as
hippocampus,
prefrontal
cortex
(PFC),
anterior
cingulate
(ACC),
amygdala-thereby
affecting
cognitive
health,
emotional
regulation,
overall
wellbeing.
Drawing
principle
neurosustainability,
suggests
long-term
exposure
stress-inducing
environments
may
create
feedback
loops,
particularly
involving
amygdala,
have
downstream
effects
other
areas
linked
adverse
outcomes
such
depression.
By
presenting
framework,
aims
inspire
further
inquiry
applied
experimental
into
intersection
neurophysiology,
environment,
with
particular
emphasis
rigorous
testing
validation
mechanisms,
then
translated
practical
architectural
design
strategies
supporting
doing
so,
hoped
work
contribute
more
holistic
approach
improving
integrates
creation
nurturing,
resilient
spaces
broader
agenda.
Язык: Английский
The Impact of Walking on BDNF as a Biomarker of Neuroplasticity: A Systematic Review
Brain Sciences,
Год журнала:
2025,
Номер
15(3), С. 254 - 254
Опубликована: Фев. 27, 2025
Background/Objectives:
The
brain-derived
neurotrophic
factor
(BDNF)
is
a
critical
exercise-induced
modulator
of
various
neuroplasticity
processes,
including
adult
hippocampal
neurogenesis.
Environmental
affordance
for
physical
activity
novel
theory
that
aims
to
increase
the
BDNF
through
walking
or
climbing
stairs,
stimulated
by
urban
and
interior
environment.
In
systematic
review,
this
paper
explores
association
between
walking,
as
structured
free-living
form
activity,
changes
in
humans
with
healthy
locomotion.
Method:
A
review
registered
protocol,
INPLASY2024110093,
following
PRISMA
guidelines,
includes
English-language
original
research
articles
on
older
human
subjects
who
are
locomotor-healthy,
studies
exercise
presented
non-combined
intervention,
must
report
dependent
variable.
search
was
conducted
using
three
databases:
PubMed,
Web
Science,
Scopus,
resulting
21
eligible
studies.
Results:
This
finds
impact
evidenced,
but
subject
moderate
high
intensities
single
bouts.
At
same
time,
long-term
effects
yet
be
fully
understood,
potentially
due
uptake
functional
brain
improvements,
muscle
repair,
instead
an
accumulation
itself,
still
confirm
important
role
neurosustainability.
Age
environmental
factors
such
heat
also
found
affect
BDNF.
narrative
synthesis
provides
elaborate
explanations
understanding
those
complex
dynamics
before
reaching
future
conclusions
concentrations.
Conclusions:
highlights
potential
played
moderate-
high-intensity
lifestyle
intervention
can
utilised
built
environment
promote
adaptive
changes,
sustainable
regulation
Язык: Английский
Effects of Mindfulness and Exercise on Growth Factors, Inflammation, and Stress Markers in Chronic Stroke: The MindFit Project Randomized Clinical Trial
Journal of Clinical Medicine,
Год журнала:
2025,
Номер
14(8), С. 2580 - 2580
Опубликована: Апрель 9, 2025
Background/Objectives:
Stroke
often
leads
to
persistent
cognitive
and
emotional
impairments,
which
rehabilitation
may
mitigate.
However,
the
biological
mechanisms
underlying
such
improvements
remain
unclear.
This
study
investigated
whether
supplementing
computerized
training
(CCT)
with
mindfulness-based
stress
reduction
(MBSR)
or
physical
exercise
(PE)
modulated
biomarkers
of
neuroplasticity,
inflammation,
in
patients
chronic
stroke
compared
CCT
alone.
We
also
explored
biomarker
changes
mediated
correlated
behavioral
improvements.
Methods:
In
a
three-arm,
single-blind,
randomized
controlled
trial
(NCT04759950),
141
were
(1:1:1)
MBSR+CCT,
PE+CCT,
CCT-only
for
12
weeks.
Plasma
levels
brain-derived
neurotrophic
factor
(BDNF),
insulin-like
growth
factor-1
(IGF-1),
vascular
endothelial
(VEGF),
C-reactive
protein
(CRP),
interleukin-6
(IL-6),
cortisol
measured
at
baseline
post-intervention.
Cognitive,
mental
health,
mindfulness,
fitness
outcomes
assessed.
Between-
within-group
analyzed
using
ANCOVA
paired
t-tests.
Per-protocol
complete-case
analyses
conducted.
Results:
Among
109
participants
≥80%
adherence,
only
significant
between-group
difference
was
VEGF:
it
remained
stable
MBSR+CCT
group
but
declined
PE+CCT
CCT-only.
Within-group
showed
decreases
while
IGF-1
across
all
groups.
contrast,
BDNF,
IL-6,
CRP
did
not
show
changes,
significantly
associated
Complete-case
analysis
(n
=
126)
yielded
similar
findings.
Conclusions:
Our
findings
suggest
that
combining
MBSR
PE
modulate
certain
processes
relevant
recovery.
help
maintain
VEGF
levels,
could
support
contribute
lowering
levels.
since
no
clear
association
found,
further
research
is
needed
determine
clinical
relevance
these
Язык: Английский