Lipid Peroxidation in Muscle Foods: Impact on Quality, Safety and Human Health

Foods, Год журнала: 2024, Номер 13(5), С. 797 - 797

Опубликована: Март 4, 2024

The issue of lipid changes in muscle foods under the action atmospheric oxygen has captured attention researchers for over a century. Lipid oxidative processes initiate during slaughtering animals and persist throughout subsequent technological processing storage finished product. oxidation lipids is phenomenon extensively deliberated scientific community, acknowledged as one pivotal factors affecting their quality, safety, human health. This review delves into nature foods, highlighting mechanisms free radical initiation propagation processes. Special given to natural antioxidant protective system dietary influencing stability lipids. traces inhibiting processes, exploring how substrates, prooxidant activity, play role. A critical safety meat products provided. impact on quality including flavour, aroma, taste, colour, texture, scrutinised. Additionally, monitors effect oxidised health, particularly relation autooxidation cholesterol. Associations with coronary cardiovascular disease, brain stroke, carcinogenesis linked stress, various infections are discussed. Further studies also needed formulate appropriate solutions reduce risk chemical hazards caused by development peroxidation foods.

Язык: Английский

---

Coumarin-transition metal complexes with biological activity: current trends and perspectives

Frontiers in Chemistry, Год журнала: 2024, Номер 12

Опубликована: Фев. 12, 2024

Coumarin (2H-1-benzopyran-2-one) presents the fundamental structure of an enormous class biologically active compounds natural, semi-synthetic, and synthetic origin. Extensive efforts are continually being put into research development coumarin derivatives with medicinal properties by broad scientific community. Transition metal coordination potential biological activity a “hot topic” in modern search for novel drugs. Complexation transition metals can enhance physiological effect molecule, modify its safety profile, even imbue it attributes interest fields medicine pharmacy. The present review aims to inform reader latest developments complexes activity, their applications, structure-activity relationships, where such be elucidated. Each section addresses certain kind (antiproliferative, antioxidant, antimicrobial, etc.), explores most recent discoveries field, and, at same time, tries offer useful perspectives future investigations.

Язык: Английский

---

Effect of dual modifications with ultrasonication and succinylation on Cicer arietinum protein-iron complexes: Characterization, digestibility, in-vitro cellular mineral uptake and preparation of fortified smoothie

Food Research International, Год журнала: 2024, Номер 186, С. 114344 - 114344

Опубликована: Апрель 21, 2024

Язык: Английский

---

Survey of Main Group Metals and Metalloids in Cancer Treatment

Inorganics, Год журнала: 2024, Номер 12(1), С. 29 - 29

Опубликована: Янв. 12, 2024

Cancer is one of the leading causes human death among all major diseases. Metal-based complexes are considered as most promising vital part in existing arsenal cytotoxic candidates used cancer therapy and diagnostics. The efforts many scientific groups resulted development numerous metal-based compounds featuring different biologically active organic ligands order to modulate their bioactivity. Along with main representatives potential therapeutic agents, such Pt(II)/Pt(IV), Pd(II), Ru(II)/Ru(III), Ag(I), Au(I)/Au(III), Ti(IV), V(IV) Ga(III), other transition metal lanthanide possessing antiproliferative activity widely discussed literature. However, drugs remain outside scope this review. purpose current study review group metal- metalloid-based against common cell types, carcinomas (lung, liver, breast, kidney, gastric, colorectal, bladder, ovarian, cervical, prostate, etc.); sarcomas; blastomas; lymphomas; multiple myeloma; melanoma. Overcoming long disregard organometallic metals metalloids from groups, a growing number emerging anticancer agents remarkably prove field offers an extensive variety new options for design innovative unexplored chemopharmaceutics. Moreover, some these elements can exhibit entirely different, specific modes action biological targets. Obviously, exploitation distinct properties deserves more attention.

Язык: Английский

---

Anticancer Metallocenes and Metal Complexes of Transition Elements from Groups 4 to 7

Molecules, Год журнала: 2024, Номер 29(4), С. 824 - 824

Опубликована: Фев. 11, 2024

With the progression in field of bioinorganic chemistry, role transition metal complexes as most widely used therapeutics is becoming a more and attractive research area. The metals possess great variety pharmacological properties, including anticancer, anti-inflammatory, antioxidant, anti-infective, etc., activities. Transition have proven to be potential alternatives biologically active organic compounds, especially antitumor agents. performance coordination compounds living systems anticipated differ generally from action non-metal-containing drugs may offer unique diagnostic and/or therapeutic opportunities. In this review, rapid development application metallocenes elements Groups 4 7 cancer diagnostics therapy been summarized. Most heavy discussed current review are newly discovered metals. That why use their metal-based has attracted lot attention concerning organometallic chemistry. All imposes systematic studies on biological activity, biocompatibility, toxicity presupposes further investigations.

Язык: Английский

---

Synthesis, Structure, and Antimicrobial Properties of New Cobalt(II) Complexes with 1-Propargylimidazoles

Current Organic Chemistry, Год журнала: 2024, Номер 28(9), С. 708 - 715

Опубликована: Апрель 9, 2024

Abstract: Complexes of cobalt(II) chloride with 1-propargylimidazole, 1-propargyl-2-methylimidazole, and 1- propargylbenzimidazole ligands were synthesized studied by FTIR spectroscopy X-ray analysis. According to the analysis, crystal molecules compounds connected non-covalent interactions, such as halogen bonds π-stacking. The nature energy coordination metal-ligand noncovalent for structures under study estimated in frame QTAIM (Quantum Theory “Atoms In Molecules”). antimicrobial activity obtained complexes was evaluated relation microorganisms E. durans, B. subtilis, coli. 1-propargyl-2-methylimidazole demonstrated high against coli durans relatively could be recommended drugs.

Язык: Английский

---

Synthesis and characterization of copper(II) complex derived from newly synthesized acenaphthene quinone thiosemicarbazone ligands: Computational studies, in vitro binding with DNA/BSA and anticancer studies

Inorganica Chimica Acta, Год журнала: 2024, Номер 574, С. 122369 - 122369

Опубликована: Сен. 6, 2024

Язык: Английский

---

Mineral Concentration in Spring Wheat Grain Under Organic, Integrated, and Conventional Farming Systems and Their Alterations During Processing

Plants, Год журнала: 2025, Номер 14(7), С. 1003 - 1003

Опубликована: Март 23, 2025

Common wheat (Triticum aestivum L.) is a key cereal in the global economy, providing essential nutrients for human and animal health. The European Union promotes less intensive farming systems as part of its sustainable development strategy. This study aimed to evaluate impact different on concentration macronutrients-potassium, phosphorus, magnesium, calcium (K, P, Mg, Ca)- micronutrients-iron, zinc, manganese, copper (Fe, Zn, Mn, Cu)-in grain, well effect grain processing distribution these bran, flour, bread. included four spring cultivars (Harenda, Kandela, Mandaryna, Serenada) grown under organic (ORG), integrated (INT), conventional (CONV) at Osiny Experimental Station (Poland; 51°27' N; 22°2' E) between 2019 2021. P was determined using colorimetric method, while other were analyzed by atomic absorption spectrometry (AAS). from CONV system exhibited higher macronutrients concentrations, whereas had micronutrients except Fe. Fe INT comparable. An interaction Ca, Cu concentrations observed. In all research material, highest minerals found followed with lowest observed flour

Язык: Английский

---

Some Biological Applications and Mechanistic Insights of Benzaldehyde‐Substituted Thiosemicarbazones and Their Metal Complexes: A Review

Natural Sciences, Год журнала: 2025, Номер unknown

Опубликована: Май 5, 2025

ABSTRACT Thiosemicarbazones (TSCs) and their metal complexes have been subjected to study over several decades. Their medicinal importance as anticancer, antioxidant, antimicrobial, antidiabetic has explored. Continual efforts made toward activity enhancement that can be achieved by making suitable structural alterations or studying structure–activity relationship (SAR). This review article focuses on TSCs derived from benzaldehyde moiety in search of antimicrobial anticancer properties. Benzaldehyde its derivatives are found many natural systems. is a first‐of‐its‐kind review, where the emphasis laid one specific how substitution alters biological activity. The also describes synthesis reaction conditions these derivatives. A comprehensive literature survey reveals suppressed formation mycolic acid emerged tyrosinase inhibitors. effect presence electron‐donating/withdrawing groups disseminated, showing substituents bonded phenyl ring considerable overall activity, particularly electron‐donating groups. Likewise, hydroxyl group para position enhanced scavenging compound. conjugated tridentate donor set consisting N, S atoms affects benzaldehyde‐derived TSC. mechanistic insights TSCs, role inhibition ribonucleoside diphosphate reductase (RR), Topoisomerase II, P‐glycoprotein (P‐gp), generation reactive oxygen species (ROS), multidrug resistance (MDR), addressed. thiosemicarbazones complexes. Anticancer activities elaborated with examples. Mechanistic antibacterial explained. /withdrawing elaborated.

Язык: Английский

---

Reduction of Ceramic Wear by Concave Dimples on the Bearing Surface in CoC Hip Implants: A Finite Element Analysis

Ceramics, Год журнала: 2025, Номер 8(2), С. 51 - 51

Опубликована: Май 7, 2025

The wear of hip prostheses represents a significant challenge for the longevity and functionality joint implants. Recent studies have explored surface texturing as strategy to enhance tribological performance. This study aims evaluate impact textured ceramic surfaces with dimples on friction reduction in ceramic-on-ceramic (CoC) prostheses. Materials Methods: Three-dimensional models without were created. Contact pressure was analyzed volume estimated using Archard’s law. Simulations conducted finite element methods (FEM) under various loading conditions. Results: Numerical simulations demonstrated that rate dimpled femoral head 0.2369 mm3/year, compared 0.286 mm3/year smooth counterpart, highlighting 17.2%. Conclusions: integration can substantially improve their durability, representing promising approach addressing issues associated prosthesis wear.

Язык: Английский

---