Lipid Peroxidation in Muscle Foods: Impact on Quality, Safety and Human Health

Foods, Journal Year: 2024, Volume and Issue: 13(5), P. 797 - 797

Published: March 4, 2024

The issue of lipid changes in muscle foods under the action atmospheric oxygen has captured attention researchers for over a century. Lipid oxidative processes initiate during slaughtering animals and persist throughout subsequent technological processing storage finished product. oxidation lipids is phenomenon extensively deliberated scientific community, acknowledged as one pivotal factors affecting their quality, safety, human health. This review delves into nature foods, highlighting mechanisms free radical initiation propagation processes. Special given to natural antioxidant protective system dietary influencing stability lipids. traces inhibiting processes, exploring how substrates, prooxidant activity, play role. A critical safety meat products provided. impact on quality including flavour, aroma, taste, colour, texture, scrutinised. Additionally, monitors effect oxidised health, particularly relation autooxidation cholesterol. Associations with coronary cardiovascular disease, brain stroke, carcinogenesis linked stress, various infections are discussed. Further studies also needed formulate appropriate solutions reduce risk chemical hazards caused by development peroxidation foods.

Language: Английский

---

Coumarin-transition metal complexes with biological activity: current trends and perspectives

Frontiers in Chemistry, Journal Year: 2024, Volume and Issue: 12

Published: Feb. 12, 2024

Coumarin (2H-1-benzopyran-2-one) presents the fundamental structure of an enormous class biologically active compounds natural, semi-synthetic, and synthetic origin. Extensive efforts are continually being put into research development coumarin derivatives with medicinal properties by broad scientific community. Transition metal coordination potential biological activity a “hot topic” in modern search for novel drugs. Complexation transition metals can enhance physiological effect molecule, modify its safety profile, even imbue it attributes interest fields medicine pharmacy. The present review aims to inform reader latest developments complexes activity, their applications, structure-activity relationships, where such be elucidated. Each section addresses certain kind (antiproliferative, antioxidant, antimicrobial, etc.), explores most recent discoveries field, and, at same time, tries offer useful perspectives future investigations.

Language: Английский

---

Effect of dual modifications with ultrasonication and succinylation on Cicer arietinum protein-iron complexes: Characterization, digestibility, in-vitro cellular mineral uptake and preparation of fortified smoothie

Food Research International, Journal Year: 2024, Volume and Issue: 186, P. 114344 - 114344

Published: April 21, 2024

Language: Английский

---

Survey of Main Group Metals and Metalloids in Cancer Treatment

Inorganics, Journal Year: 2024, Volume and Issue: 12(1), P. 29 - 29

Published: Jan. 12, 2024

Cancer is one of the leading causes human death among all major diseases. Metal-based complexes are considered as most promising vital part in existing arsenal cytotoxic candidates used cancer therapy and diagnostics. The efforts many scientific groups resulted development numerous metal-based compounds featuring different biologically active organic ligands order to modulate their bioactivity. Along with main representatives potential therapeutic agents, such Pt(II)/Pt(IV), Pd(II), Ru(II)/Ru(III), Ag(I), Au(I)/Au(III), Ti(IV), V(IV) Ga(III), other transition metal lanthanide possessing antiproliferative activity widely discussed literature. However, drugs remain outside scope this review. purpose current study review group metal- metalloid-based against common cell types, carcinomas (lung, liver, breast, kidney, gastric, colorectal, bladder, ovarian, cervical, prostate, etc.); sarcomas; blastomas; lymphomas; multiple myeloma; melanoma. Overcoming long disregard organometallic metals metalloids from groups, a growing number emerging anticancer agents remarkably prove field offers an extensive variety new options for design innovative unexplored chemopharmaceutics. Moreover, some these elements can exhibit entirely different, specific modes action biological targets. Obviously, exploitation distinct properties deserves more attention.

Language: Английский

---

Anticancer Metallocenes and Metal Complexes of Transition Elements from Groups 4 to 7

Molecules, Journal Year: 2024, Volume and Issue: 29(4), P. 824 - 824

Published: Feb. 11, 2024

With the progression in field of bioinorganic chemistry, role transition metal complexes as most widely used therapeutics is becoming a more and attractive research area. The metals possess great variety pharmacological properties, including anticancer, anti-inflammatory, antioxidant, anti-infective, etc., activities. Transition have proven to be potential alternatives biologically active organic compounds, especially antitumor agents. performance coordination compounds living systems anticipated differ generally from action non-metal-containing drugs may offer unique diagnostic and/or therapeutic opportunities. In this review, rapid development application metallocenes elements Groups 4 7 cancer diagnostics therapy been summarized. Most heavy discussed current review are newly discovered metals. That why use their metal-based has attracted lot attention concerning organometallic chemistry. All imposes systematic studies on biological activity, biocompatibility, toxicity presupposes further investigations.

Language: Английский

---

Mineral Concentration in Spring Wheat Grain Under Organic, Integrated, and Conventional Farming Systems and Their Alterations During Processing

Plants, Journal Year: 2025, Volume and Issue: 14(7), P. 1003 - 1003

Published: March 23, 2025

Common wheat (Triticum aestivum L.) is a key cereal in the global economy, providing essential nutrients for human and animal health. The European Union promotes less intensive farming systems as part of its sustainable development strategy. This study aimed to evaluate impact different on concentration macronutrients-potassium, phosphorus, magnesium, calcium (K, P, Mg, Ca)- micronutrients-iron, zinc, manganese, copper (Fe, Zn, Mn, Cu)-in grain, well effect grain processing distribution these bran, flour, bread. included four spring cultivars (Harenda, Kandela, Mandaryna, Serenada) grown under organic (ORG), integrated (INT), conventional (CONV) at Osiny Experimental Station (Poland; 51°27' N; 22°2' E) between 2019 2021. P was determined using colorimetric method, while other were analyzed by atomic absorption spectrometry (AAS). from CONV system exhibited higher macronutrients concentrations, whereas had micronutrients except Fe. Fe INT comparable. An interaction Ca, Cu concentrations observed. In all research material, highest minerals found followed with lowest observed flour

Language: Английский

---

Synthesis, Structure, and Antimicrobial Properties of New Cobalt(II) Complexes with 1-Propargylimidazoles

Current Organic Chemistry, Journal Year: 2024, Volume and Issue: 28(9), P. 708 - 715

Published: April 9, 2024

Abstract: Complexes of cobalt(II) chloride with 1-propargylimidazole, 1-propargyl-2-methylimidazole, and 1- propargylbenzimidazole ligands were synthesized studied by FTIR spectroscopy X-ray analysis. According to the analysis, crystal molecules compounds connected non-covalent interactions, such as halogen bonds π-stacking. The nature energy coordination metal-ligand noncovalent for structures under study estimated in frame QTAIM (Quantum Theory “Atoms In Molecules”). antimicrobial activity obtained complexes was evaluated relation microorganisms E. durans, B. subtilis, coli. 1-propargyl-2-methylimidazole demonstrated high against coli durans relatively could be recommended drugs.

Language: Английский

---

Antioxidant, Cytotoxicity, and Anti-inflammation Activities of Phenanthroline Adducts of Zn(II) and Ni(II) bis(N-alkyl-N-phenyldithiocarbamate)

Chemistry Africa, Journal Year: 2024, Volume and Issue: 7(4), P. 2005 - 2016

Published: Jan. 18, 2024

Abstract In this study, 4,7-diphenyl-1,10-phenanthroline adducts of Ni(II) and Zn(II) N -methyl or ethyl- -phenyldithiocarbamate were synthesized the final represented as [Zn(L 1 ) 2 L 3 ] , [Ni(L (where = methyl, ethyl, bathophenanthroline) characterized using various spectroscopic techniques elemental analysis. Both FT-IR NMR analysis suggest that all possessed six coordination geometry by metal atom centres upon emergence a new M-N bond. This was shown changes observed in peaks chemical shifts comparison to parent complexes. The cytotoxicity, antioxidant, anti-inflammatory properties evaluated different assays ascertain their biological properties. assays, no noticeable trend between similar ligands metals. Nevertheless, antioxidant good moderate activity observed, especially DPPH assay, which gave best radical scavenging Additionally, estimated IC 50 values 0.011 14.76 µM calculated for cytotoxicity human cervical cancer (HeLa) cell line both adducts, respectively, 5-Flurouracil (17.48 µM). On other hand, very low found most embryonic kidney 293 (HEK 293) lines, demonstrating its superior amongst adduct standard drug. Moreover, exhibited compared diclofenac, controlled These findings thus particularly ], hold promise potential anticancer agents warrant further evaluation through clinical trials.

Language: Английский

---

Application of metallic nanoparticles-amyloid protein supramolecular materials in tissue engineering and drug delivery: Recent progress and perspectives

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 244, P. 114185 - 114185

Published: Aug. 28, 2024

Language: Английский

---

A review on recent advances of iron-based macrocyclic complexes as prominent candidate for several potential applications

Journal of the Iranian Chemical Society, Journal Year: 2023, Volume and Issue: 21(2), P. 305 - 326

Published: Dec. 27, 2023

Language: Английский

---