Long COVID-19 Effects (Chronic Covid-19 syndrome) in Nepalese Cohort recovered from SARS-CoV-2 infection DOI Open Access
Anu Dahal

Research Review, Год журнала: 2023, Номер unknown

Опубликована: Дек. 25, 2023

Background: Novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological virus for COVID-19 infection. It was first identified in Wuhan, PRC, December 2019. After this, highly contagious spread globally and responsible ongoing pandemic. Patients infected with present a wide range of symptoms among which, fever, anosmia, ageusia, cough, headache, fatigue, dyspnoea are common ones. Although most patients infection recover completely, considerable number people have persistent even after initial phase The main objective this study to assess long effects associate it different variables. Methods: This single-center retrospective cohort includes all GWT pensioners, their immediate family members, staff who had confirmed by RT-PCR from January 2020 2021, whose signs persisted or did not return normal beyond two weeks disease onset. structured survey questionnaire used collect necessary information on them. data collected initially recorded Microsoft Excel later analyzed statistically using Statistical Package Social Science (SPSS). Result: Of 300 patients, 77% ( n=231) symptoms. mean age 66 ±11.4 years 50.3% were female. during COVID_19 myalgia, decrease appetite, loss taste smell etc. Majority patient 22.7%). prevalent fatigue 57%), hair loss,(24%), dyspnea 15.6%), cough (15.3%) weight (13.3%). On systemwise classification symptoms, commonly affected system general followed , dermatological neuro-psychiatric system, ENT gastrointestinal system. There significant statistical association P<0.05) between presence gender (more likely female), group more younger group) mode isolation hospitalized patients). Conclusion: confirms high prevalence COVID-19-recovered patients.

Язык: Английский

SARS-CoV-2 Reinfections and Long COVID in the Post-Omicron Phase of the Pandemic DOI Open Access

Fotini Boufidou,

Snežana Medić, Vicky Lampropoulou

и другие.

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(16), С. 12962 - 12962

Опубликована: Авг. 19, 2023

We are reviewing the current state of knowledge on virological and immunological correlates long COVID, focusing recent evidence for possible association between increasing number SARS-CoV-2 reinfections parallel pandemic COVID. The severity largely depends initial episode; in turn, this is determined both by a combination genetic factors, particularly related to innate immune response, pathogenicity specific variant, especially its ability infect induce syncytia formation at lower respiratory tract. cumulative risk COVID as well various cardiac, pulmonary, or neurological complications increases proportionally infections, primarily elderly. Therefore, cases expected remain high future. Reinfections apparently increase likelihood but less so if they mild asymptomatic children adolescents. Strategies prevent urgently needed, among older adults who have higher burden comorbidities. Follow-up studies using an established case definition precise diagnostic criteria people with without reinfection may further elucidate contribution burden. Although accumulating supports vaccination, before after infection, preventive strategy reduce more robust comparative observational studies, including randomized trials, needed provide conclusive effectiveness vaccination preventing mitigating all age groups. Thankfully, answers not only prevention, also treatment options rates recovery from gradually starting emerge.

Язык: Английский

Процитировано

51
Post-acute sequelae of SARS-CoV-2 infection (Long COVID) in older adults DOI
Samantha Russell,

Karen Parker,

Andrea Lehoczki

и другие.

GeroScience, Год журнала: 2024, Номер unknown

Опубликована: Июнь 14, 2024

Язык: Английский

Процитировано

10
Clinical coding of long COVID in primary care 2020–2023 in a cohort of 19 million adults: an OpenSAFELY analysis DOI
Alasdair Henderson,

Ben Butler-Cole,

John Tazare

и другие.

EClinicalMedicine, Год журнала: 2024, Номер 72, С. 102638 - 102638

Опубликована: Май 17, 2024

Язык: Английский

Процитировано

8
Viable SARS-CoV-2 Omicron sub-variants isolated from autopsy tissues DOI Creative Commons

Santiago Maffia‐Bizzozero,

Cintia Cevallos, Federico Remes Lenicov

и другие.

Frontiers in Microbiology, Год журнала: 2023, Номер 14

Опубликована: Май 22, 2023

Pulmonary and extrapulmonary manifestations have been described after infection with SARS-CoV-2, the causative agent of coronavirus disease 2019 (COVID-19). The virus is known to persist in multiple organs due its tropism for several tissues. However, previous reports were unable provide definitive information about whether viable transmissible. It has hypothesized that persisting reservoirs SARS-CoV-2 tissues could be one potentially overlapping causes long COVID.In present study, we investigated autopsy materials obtained from 21 cadaveric donors documented first or reinfection at time death. cases studied included recipients different formulations COVID-19 vaccines. aim was find presence lungs, heart, liver, kidneys, intestines. We used two technical approaches: detection quantification viral genomic RNA using RT-qPCR, infectivity permissive vitro Vero E6 culture.All analyzed showed but dissimilar levels ranging 1.01 × 102 copies/mL 1.14 108 copies/mL, even among those who had vaccinated. Importantly, amounts replication-competent detected culture media highest load measured lung (≈1.4 106 copies/mL) heart (≈1.9 samples. Additionally, based on partial Spike gene sequences, characterization revealed Omicron sub-variants exhibiting a high level nucleotide amino acid identity them.These findings highlight can spread tissue locations such as intestines, both primary reinfections variant, contributing extending knowledge pathogenesis acute understanding sequelae clinical are observed during post-acute COVID-19.

Язык: Английский

Процитировано

15
Self-Reported Post-COVID Symptoms at 18 Months After Infection Among Adults in Southern Brazil: A Cross-Sectional Study DOI Open Access
Franciele Aline Machado de Brito, Carlos Laranjeira, Márcia Moroskoski

и другие.

Healthcare, Год журнала: 2025, Номер 13(3), С. 228 - 228

Опубликована: Янв. 23, 2025

Background/Objectives: Currently, there is a limited understanding of the long-term consequences following acute COVID-19, referred to as long COVID. This cross-sectional study aims analyze prevalence persistent signs and symptoms COVID, 18 months after primary SARS-CoV-2 infection in adults southern Brazil. Methods: Using two national databases (the digital registry positive cases), 370 individuals living state Paraná (Brazil) were recruited. Data collected through telephone interviews conducted 2021 2022. Results: The overall COVID was 66.2% among participants. During phase infection, most common symptom clusters included neurological (87.0%; n = 318), followed by respiratory (82.0%; 301), musculoskeletal (66.0%; 241), digestive (50.0%; 184), psychological (38.0%; 138), endocrine (28.0%; 104). In month follow-up, main memory loss (42.7%), fatigue (32.2%), anxiety (23.5%), dyspnea (19.7%), hair (19.7%). proportion participants with statistically higher females (73.9%), those family income below minimum wages (94.7%), who do not practice physical activity (83.3%), report poor sleep quality (93.3%), use medication (85.9%), needed health care previous six (87.3%), required professional and/or (79.3%), ICU (79.0%), used ventilatory support (77.5%). Conclusions: Long complex condition that requires monitoring investment services due its high population.

Язык: Английский

Процитировано

0
Factors affecting the impact of COVID-19 vaccination on post COVID-19 conditions among adults: A systematic literature review DOI Creative Commons
Abby E. Rudolph,

Nadine Al Akoury,

Natalija Bogdanenko

и другие.

Human Vaccines & Immunotherapeutics, Год журнала: 2025, Номер 21(1)

Опубликована: Март 13, 2025

This systematic literature review summarizes the evidence across 56 publications and pre-prints (January 2020–July 2023) with low-risk of bias based on JBI critical appraisal, that report adjusted estimates for relationship between COVID-19 vaccination Post-COVID-19 Condition (PCC) by timing relative to infection or PCC-onset. Comparisons vaccine effectiveness (aVE) against ≥1 PCC (vs. unvaccinated) study characteristics known impact burden VE other endpoints were possible 31 studies where preceded infection. Seventy-seven percent pre-infection aVE statistically significant (range: 7%–95%). Statistically slightly higher mRNA 14%–84%) than non-mRNA vaccines 16%–38%) ranges before during Omicron overlapped. Our findings suggest SARS-CoV-2 reduces risk regardless type, number doses received, definition, predominant variant, severity acute infections included.

Язык: Английский

Процитировано

0
Burden of acute and long-term COVID-19: a nationwide study in Bahrain DOI Creative Commons

Mariam Murad,

Stephen L. Atkin, Pearl Wasif

и другие.

Frontiers in Public Health, Год журнала: 2025, Номер 13

Опубликована: Март 18, 2025

Coronavirus disease 2019 (COVID-19) may lead to long-term sequelae. This study aimed understand the acute and post-acute burden of SARS-CoV-2 infection identify high-risk groups for post-COVID-19 conditions (PCC). A retrospective observational Bahraini population was conducted between 1 May 2021 30 April 2023, utilizing national administrative database. PCC cases were defined according WHO guidelines. All COVID-19 confirmed using real-time polymerase chain reaction (PCR). Of 13,067 cases, 12,022 them experienced COVID-19, 1,045 developed PCC. Individuals with tended be older women risk factors instances reinfection. The incidence rates per 100,000 individuals during Alpha pandemic surge (2020), Delta (2021), Omicron (2022) 2.2, 137.2, 222.5 0.27, 10.5, 19.3, respectively, cases. death Alpha, Delta, surges 3, 112, 76, 1, 10, 8, rate highest among those aged 65 surge. These findings suggest need a timely vaccination program prior new prevent complications related infection, particularly in adult non-older factors.

Язык: Английский

Процитировано

0
COVID-19 Infection Associated with Increased Risk of New-Onset Vascular Dementia in Adults Aged 50 Years and Older: A Longitudinal Cohort Study Using Data from the UK Biobank DOI
Dan Shan,

Yanli Xü,

Chuang Yang

и другие.

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
A systematic review of the evidence on the associations and safety of COVID-19 vaccination and post COVID-19 condition DOI Creative Commons

Sydney Jennings,

Tricia Corrin, Lisa Waddell

и другие.

Epidemiology and Infection, Год журнала: 2023, Номер 151

Опубликована: Янв. 1, 2023

Abstract Post COVID-19 condition (PCC) refers to persistent or recurring symptoms (>8 weeks) occurring ≤12 weeks following acute COVID-19. The objective of this systematic review was assess the evidence on risk PCC with vaccination before after developing PCC, and safety among those already experiencing PCC. A search conducted up 13 December 2022 standard methodology followed. Thirty-one observational studies were included. There is moderate confidence that two doses vaccine given pre-infection reduced odds (pooled OR (pOR) 0.67, 95% CI 0.60–0.74, I2 = 59.9%), but low one dose may not reduce (pOR 0.64, 0.31#x2013;1.31, 99.2%), very uncertain about effect three 0.45, 0.10#x2013;1.99, 30.9%). One suggested shortly offer additional protection from compared unvaccinated individuals, uncertain. For associated worsening (10 studies) appears safe (3 studies), it unclear if change established symptoms.

Язык: Английский

Процитировано

8
Prevalence and risk factors of post-acute sequelae of COVID-19 among United States Veterans DOI

Michela D. Stephens,

Julie A. Gazmararian, Anjali Khakharia

и другие.

Annals of Epidemiology, Год журнала: 2023, Номер 89, С. 1 - 7

Опубликована: Ноя. 15, 2023

Язык: Английский

Процитировано

8