Gynécologie Obstétrique Fertilité & Sénologie , Год журнала: 2022, Номер 50(11), С. 712 - 720
Опубликована: Июль 30, 2022
Язык: Английский
Vaccine, Год журнала: 2023, Номер 41(25), С. 3688 - 3700
Опубликована: Март 27, 2023
Assessment of COVID-19 vaccines safety during pregnancy is urgently needed.
Язык: Английский
Процитировано
46
Reviews in Medical Virology, Год журнала: 2023, Номер 33(3)
Опубликована: Март 10, 2023
SARS-CoV-2 infection during pregnancy is associated with adverse maternal and neonatal outcomes, but no systematic synthesis of evidence on COVID-19 vaccination against these outcomes has been undertaken. Thus, we aimed to assess the collective effects outcomes. PubMed/MEDLINE, CENTRAL, EMBASE were systematically searched for articles published up 1 November 2022. A review meta-analysis performed calculate pooled size 95% confidence interval (CI). We evaluated 30 studies involving 862,272 individuals (308,428 vaccinated 553,844 unvaccinated). Overall analyses in pregnant women showed reduced risks by 60% (41%-73%), hospitalisation 53% (31%-69%), intensive care unit (ICU) admission 82% (12%-99%). Neonates 1.78 folds more likely acquire first 2, 4 6 months life Omicron period. The risk stillbirth was 45% (17%-63%) association (vs. vaccination) pregnancy. decrease 15% (3%-25%), 33% (14%-48%), (17%-46%) odds preterm births before 37, 32 28 weeks' gestation pregnancy, respectively. ICU significantly lower 20% following (16%-24%). There a higher including miscarriage, gestational diabetes, hypertension, cardiac problems, oligohydramnios, polyhydramnios, unassisted vaginal delivery, cesarean postpartum haemorrhage, age at placental abruption, Apgar score 5 min below 7, low birthweight (<2500 g), very (<1500 small age, foetal abnormalities. safe highly effective preventing without increasing reduction stillbirth, births, admission. Importantly, did not reduce
Язык: Английский
Процитировано
45
Human Reproduction, Год журнала: 2023, Номер 38(5), С. 840 - 852
Опубликована: Фев. 16, 2023
Abstract STUDY QUESTION What is the risk of miscarriage among pregnant women who received any COVID-19 vaccines? SUMMARY ANSWER There no evidence that vaccines are associated with an increased miscarriage. WHAT IS KNOWN ALREADY In response to pandemic, mass roll-out helped boost herd immunity and reduced hospital admissions, morbidity, mortality. Still, many were concerned about safety for pregnancy, which may have limited their uptake those planning a pregnancy. DESIGN, SIZE, DURATION For this systematic review meta-analysis, we searched MEDLINE, EMBASE, Cochrane CENTRAL from inception until June 2022 using combination keywords MeSH terms. PARTICIPANTS/MATERIALS, SETTING, METHODS We included observational interventional studies enrolled evaluated available compared placebo or vaccination. primarily reported on in addition ongoing pregnancy and/or live birth. MAIN RESULTS AND THE ROLE OF CHANCE data 21 (5 randomized trials 16 studies) reporting 149 685 women. The pooled rate vaccine was 9% (n = 14 749/123 185, 95% CI 0.05–0.14). Compared vaccination, did not higher (risk ratio (RR) 1.07, 0.89–1.28, I2 35.8%) had comparable rates birth (RR 1.00, 0.97–1.03, 10.72%). LIMITATIONS, REASONS FOR CAUTION Our analysis varied reporting, high heterogeneity bias across studies, limit generalizability confidence our findings. WIDER IMPLICATIONS FINDINGS increase reproductive age. current remains larger population needed further evaluate effectiveness vaccination FUNDING/COMPETING INTEREST(S) No direct funding provided support work. M.P.R. funded by Medical Research Council Centre Reproductive Health Grant No: MR/N022556/1. B.H.A.W. hold personal development award National Institute UK. All authors declare conflict interest. REGISTRATION NUMBER CRD42021289098.
Язык: Английский
Процитировано
22
Obstetrics and Gynecology Clinics of North America, Год журнала: 2023, Номер 50(2), С. 279 - 297
Опубликована: Фев. 21, 2023
Язык: Английский
Процитировано
22
Journal of Clinical Medicine, Год журнала: 2022, Номер 11(23), С. 6982 - 6982
Опубликована: Ноя. 26, 2022
In many countries, preterm birth, defined as birth before 37 completed weeks of gestation, is the primary cause infant death and morbidity. An increasing body research suggests that inflammation (both clinical subclinical) plays a significant role in inducing labor or developing pregnancy problems lead to premature birth. Consequently, purpose this was determine predictive value Neutrophil-Lymphocyte Ratio (NLR), derived (dNLR), Monocytes-to-Lymphocyte (MLR), Platelets-to-Lymphocyte (PLR), Systemic immune-inflammation index (SII), systemic inflammatory response (SIRI), for delivery. A retrospective study analyzed total 243 eligible pregnancies resulted during 2020 2021. control group without history matched by age trimester laboratory analysis at 1:1 ratio. Although number comorbidities similar among groups, body-mass estimated week gestation significantly higher patients from prematurity group, well prevalence urinary tract infections smoking. Laboratory data showed with had white blood cell count monocytes, but lower lymphocytes, platelets, hemoglobin. The NLR, dNLR, PLR, MLR scores be SII SIRI were not different between groups. It observed AUC values than 0.600, respectively NLR highest tested (AUC = 0.694) sensitivity (71%). sensibility achieved 70%, an 0.655 (p-value 0.022). PLR second-highest (0.682) best score terms (70%) (69%) 0.015). Lastly, lowest (0.607) sensitivity/sensibility. cut-off 9.0 9.8 250 4.07 MLR. After evaluating importance these scores, further applications should conducted confirm results improve therapy care reduce burden deliveries.
Язык: Английский
Процитировано
30
Pediatric Research, Год журнала: 2023, Номер 94(1), С. 34 - 42
Опубликована: Янв. 3, 2023
Abstract Background The safety of coronavirus disease 2019 (COVID-19) vaccines during pregnancy is a particular concern. Here, we addressed the neonatal outcomes after maternal vaccination COVID-19 pregnancy. Methods We systematically searched PubMed, EMBASE, and WHO Database for studies on from inception to 3 July 2022. Main were related preterm, small gestation (SGA), NICU admission, low Apgar score at 5 min (<7), additional such as <34 weeks, birth weight some morbidity all also analyzed. Results A total 15 included. found that was reduction rates Preterm, SGA, Low (<7). In addition, there no evidence higher risk adverse pregnancy, including preterm with weight, very congenital anomalies, so on. Conclusions in pregnant women does not raise significant effects protective effect outcomes. Impact Present study has present could encourage be vaccinated against COVID-19.
Язык: Английский
Процитировано
21
Frontiers in Public Health, Год журнала: 2023, Номер 11
Опубликована: Янв. 30, 2023
Objectives The low COVID-19 vaccine uptake rate among pregnant women is mainly due to safety concerns about vaccines limited evidence. Our goal was evaluate the of vaccination during pregnancy with up-to-date Methods A comprehensive search MEDLINE, EMBASE, Cochrane Library, and clinicaltrials.gov performed on April 5th, 2022, updated May 25th, 2022. Studies evaluating association adverse maternal neonatal outcomes were included. Two reviewers independently risk bias assessment data extraction. Inverse variance random effect meta-analyses pool outcome data. Results Forty-three observational studies [96,384 (73.9%) BNT162b2, 30,889 (23.7%) mRNA-1273, 3,172 (2.4%) other types] [23,721 (18.3%) in first trimester, 52,778 (40.5%) second 53,886 (41.2%) third trimester].was associated reduced risks stillbirth or death (OR, 0.74; 95% CI, 0.60–0.92). Sensitivity analysis restricted participants without showed that pooled not robust. congenital anomalies 0.83; 0.63–1.08), preterm birth 0.98; 0.90–1.06), NICU admission hospitalization 0.94; 0.84–1.04), an Apgar score at 5 min <7 0.93; 0.86–1.01), weight 1.00; 0.88–1.14), miscarriage 0.99; 0.88–1.11), cesarean delivery 1.07; 0.96–1.19), postpartum hemorrhage 0.91; 0.81–1.01). Conclusions any studied. Interpretation study findings by types timing vaccination. vaccinations our received primarily mRNA administered trimester. Future RCTs meta-analysis are warranted efficacy long-term effects vaccines. Systematic review registration https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022322525 , identifier: PROSPERO, CRD42022322525.
Язык: Английский
Процитировано
19
BMJ Global Health, Год журнала: 2024, Номер 9(4), С. e014247 - e014247
Опубликована: Апрель 1, 2024
Objective To assess the effects of COVID-19 vaccines in women before or during pregnancy on SARS-CoV-2 infection-related, pregnancy, offspring and reactogenicity outcomes. Design Systematic review meta-analysis. Data sources Major databases between December 2019 January 2023. Study selection Nine pairs reviewers contributed to study selection. We included test-negative designs, comparative cohorts randomised trials infection-related Non-comparative cohort studies reporting outcomes were also included. Quality assessment, data extraction analysis Two independently assessed quality extracted data. undertook random-effects meta-analysis reported findings as HRs, risk ratios (RRs), ORs rates with 95% CIs. Results Sixty-seven (1 813 947 women) Overall, design studies, pregnant fully vaccinated any vaccine had 61% reduced odds infection (OR 0.39, CI 0.21 0.75; 4 23 927 women; I 2 =87.2%) 94% hospital admission 0.06, 0.01 0.71; 868 =92%). In adjusted hypertensive disorders was by 12% (RR 0.88, 0.82 0.92; studies; 115 085 women), while caesarean section 9% 0.91, 0.85 0.98; 6 30 192 women). observed an 8% reduction neonatal intensive care unit 0.92, 0.87 0.97; 54 569 babies born versus not women. general, vaccination associated increased adverse perinatal Pain at injection site most common side effect (77%, 52% 94%; 11 27 195 Conclusion are effective preventing related complications PROSPERO registration number CRD42020178076.
Язык: Английский
Процитировано
7
Drug Safety, Год журнала: 2024, Номер 47(10), С. 991 - 1010
Опубликована: Июль 15, 2024
Pregnant persons are susceptible to significant complications following COVID-19, even death. However, worldwide COVID-19 vaccination coverage during pregnancy remains suboptimal.
Язык: Английский
Процитировано
6
Journal of Clinical Medicine, Год журнала: 2022, Номер 11(22), С. 6803 - 6803
Опубликована: Ноя. 17, 2022
Many elderly patients with severe SARS-CoV-2 infections and COVID-19 are admitted to intensive care units. Age was previously identified as an independent risk factor for death contributed the greater severity of COVID-19. The may have diminished lung functions, poor reactions artificial ventilation, compromised immune systems. However, it is yet uncertain how each pandemic wave predominant strains contribute varying results patient groups such impacted. Comparing six waves, objective this study examine variation in case severity, symptomatology, ICU hospitalizations, mortality among SARS-CoV-2-infected individuals. followed a retrospective design, including 60 eligible older than 70 years groups, after matching them by number comorbidities gender. infection during first, third, fourth waves had significantly higher hospitalized patients. Confusion dyspnea at admission were significant factors (β = 1.92, respectively β 3.65). laboratory parameters decreased lymphocytes 2.11), elevated IL-6 1.96), procalcitonin 2.46) most factors. third considerably more (31.7% 26.7%) sixth (13.3%). Median stay percentage receiving oxygen support also differed across waves. rates between similar. average length hospitalization varied dramatically Although senior likely worse outcomes hospitalization, mitigated prevalence frailty elderly. that specifically evaluated did not reveal disproportionate variations terms mortality; however, wave, there Romania. It probable certain circulating infectious, resulting increase strain on healthcare systems, which might explain found our research.
Язык: Английский
Процитировано
18