Elsevier eBooks, Год журнала: 2023, Номер unknown, С. 312 - 325
Опубликована: Авг. 3, 2023
Язык: Английский
Nature Reviews Neurology, Год журнала: 2024, Номер 20(2), С. 99 - 113
Опубликована: Янв. 11, 2024
Язык: Английский
Процитировано
20
Journal of Clinical Medicine, Год журнала: 2022, Номер 11(18), С. 5400 - 5400
Опубликована: Сен. 14, 2022
Alteration in gut microbiota has been associated with COVID-19. However, the underlying mechanisms remain poorly understood. Here, we outlined three potential interconnected mechanistic pathways leading to dysbiosis as an adverse outcome following SARS-CoV-2 presence gastrointestinal tract. Evidence from literature and current uncertainties are reported for each step of different pathways. One pathway investigates evidence that intestinal infection by inducing inflammation alters microbiota. Another links binding viral S protein angiotensin-converting enzyme 2 (ACE2) dysregulation this receptor, essential homeostasis—notably amino acid metabolism—leading dysbiosis. Additionally, could induce infecting bacteria. Assessing within Adverse Outcome Pathway framework justifies confidence proposed support disease management permits identification inconsistencies knowledge gaps orient further research.
Язык: Английский
Процитировано
30
ALTEX, Год журнала: 2023, Номер unknown
Опубликована: Янв. 1, 2023
The adverse outcome pathways (AOPs) were developed to accelerate evidence-based chemical risk assessment by leveraging data from new approach methodologies. Thanks their stressor-agnostic approach, AOPs seen as instrumental in other fields. Here, we present that report non-chemical stressors along with the challenges encountered for development. Challenges regarding linked nanomaterials include non-specific molecular initiating events, limited understanding of nanomaterial biodistribution, and needs adaptations silico modeling testing systems. Development radiation face how incorporate ionizing events type, dose rate, energy deposition, account targeting multiple macromolecules. COVID-19 required inclusion SARS-CoV-2-specific replicative steps capture essential driving disease. Developing evaluate efficacy toxicity cell therapies necessitates addressing cellular nature therapeutic function stressor. Finally, emerging biological like microbial pesticides can learn AOPs. We further discuss needed expand AOP applicability beyond chemicals are mainly at levels while downstream key tissue or organ level, such inflammation, shared many initiated various stressors. In conclusion, although it is challenging integrate within AOPs, this expands opportunities real-world scenarios, identify vulnerable individuals, bridge knowledge on mechanisms adversity. Plain language summaryThe pathway (AOP) framework was help predict whether have toxic effects humans. Structuring available information an accessible database reduce animal testing. usually path interaction a stressor, chemical, human body outcome, e.g., disease symptom. concept has now been expanded nanomaterials, radiation, viruses, cells used treat patients, microorganisms employed pesticides. use these need be accommodated point out share inflammation By integrating into framework, scenarios where people may exposed different stressor types considered, individuals identified, compounded.
Язык: Английский
Процитировано
9
Gastroenterology Review, Год журнала: 2023, Номер 18(2), С. 175 - 182
Опубликована: Янв. 1, 2023
It is known that the virus SARS-CoV-2 can attack gastrointestinal (GI) tract and induce gastroenteritis. This trigger a wide variety of disorders gut-brain interaction (DGBIs) or functional (FGIDs), including post-infectious dyspepsia, which remains underestimated.To estimate prevalence dyspeptic symptoms following COVID-19, immediately after discharge 3, 6, 9 months hospitalization.A prospective, single-centre evaluation questions regarding dyspepsia (FD) as assessed by Gastroduodenal Module ROME IV Diagnostic Questionnaire for Adult FGIDs among 320 patients who had COVID-19.The FD criteria were met at respective time-points 0.0% (0), 4.8% (12), 3.2% (8), (8) cases. However, presence GI suggested but did not meet timeframe found in 9.6% (24), 23.5% (59), 20.7% (52), (52) cases, respectively.The persistence COVID-19 significant problem. The Rome may underestimate number with persistent disease.
Язык: Английский
Процитировано
8
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(24), С. 17198 - 17198
Опубликована: Дек. 6, 2023
The current understanding of long COVID (LC) is still limited. This review highlights key findings regarding the role gut microbiota, mitochondria, and main pathophysiological aspects LC revealed by clinical studies, related to complex interplay between infection, intestinal dysbiosis, dysfunctional systemic inflammation generated in a vicious circle, reflecting molecular cellular processes from "leaky gut" electron transport chain (ETC)" into quantum leap. heterogeneity has hindered progress deciphering all mechanisms, therefore, approach must be multidisciplinary, with special focus not only on symptomatic management but also addressing underlying health problems patients. It imperative further assess validate effects COVID-19 microbiome their relationship infections other viral agents or pathogens. Further studies are needed better understand expand interdisciplinary points view that required accurately diagnose effectively treat this heterogeneous condition. Given ability SARS-CoV-2 induce autoimmunity susceptible patients, they should monitored for symptoms autoimmune disease after contracting infection. One question remains open, namely, whether various vaccines developed end pandemic will autoimmunity. Recent data highlighted have persistence mitochondria organs such as heart and, lesser extent, kidneys, liver, lymph nodes, organism been able clear virus lungs, could an explanation LC.
Язык: Английский
Процитировано
7
Frontiers in Public Health, Год журнала: 2023, Номер 11
Опубликована: Авг. 10, 2023
Introduction The CIAO project was launched in Spring 2020 to address the need make sense of numerous and disparate data available on COVID-19 pathogenesis. Based a crowdsourcing model large-scale collaboration, has exploited Adverse Outcome Pathway (AOP) knowledge management framework built support chemical risk assessment driven by mechanistic understanding biological perturbations at different organizational levels. Hence AOPs might have real potential integrate produced through approaches from disciplines as experienced context COVID-19. In this study, we aim effectiveness AOP (i) supporting an interdisciplinary collaboration for viral disease (ii) working conceptual mediator collaboration. Methods We used survey disseminated among participants, workshop open all interested contributors, series interviews with some participants self-reflection processes. Results supported genuine interdisciplinarity exchange knowledge. provided common reference point discussion diagram assisted making explicit what are perspectives brought about pathways. AOP-Wiki showed up many aspects its usability those not already world AOPs. Meanwhile their use highlighted needed adaptations. new Wiki elements modulating factors potentially most disruptive one. Regarding how well that is successful when there strong central impetus clarity terms early possible. Discussion Extrapolate approach related processes other areas science where could foster systematic organization exciting perspective.
Язык: Английский
Процитировано
6
Applied and Environmental Microbiology, Год журнала: 2024, Номер 90(11)
Опубликована: Окт. 10, 2024
ABSTRACT The aim of this study was to evaluate whether community-level monitoring respiratory and enteric viruses in wastewater can provide a comprehensive picture local virus circulation. Wastewater samples were collected weekly at the treatment plant (WWTP) inlet outlet nearby nursing home (NH) Burgundy, France, during winter period 2022/2023. We searched for pepper mild mottle as an indicator fecal content well main [severe acute syndrome coronavirus 2 (SARS-CoV-2), influenza, syncytial virus] (rotavirus, sapovirus, norovirus, astrovirus, adenovirus). Samples analyzed using real-time reverse transcription PCR-based methods. SARS-CoV-2 most frequently detected virus, with 66.7% positive from WWTP 28.6% NH. Peaks consistent chronological incidence infections recorded sentinel surveillance hospital databases. number lower NH than three viruses. Enteric detected, often sapovirus norovirus genogroup II, accounting both 77.8% 57.1% 37%, respectively, large circulation unexpected particular Combined simple optimized methods be valuable tool viral may serve suitable early warning system identifying outbreaks onset epidemics. These results encourage application wastewater-based (WBS) SARS-CoV2, sapovirus. IMPORTANCE WBS provides information on spread epidemic environment appropriate sensitive detection By PCR retirement (connected same collective sewer network), we aimed demonstrate that implementing combined key community sites allows effective occurrence (influenza, SARS-CoV-2) (norovirus, rotavirus, sapovirus) within given population. This analysis localized scale provided new two different sites. Implementing monitor or emergence infectious diseases is important means alerting authorities improving public health management. could participate actively humans, animals, environment.
Язык: Английский
Процитировано
2
bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Фев. 28, 2024
ABSTRACT Many COVID-19 patients suffer from gastrointestinal symptoms and impaired intestinal barrier function may play a key role in Long COVID. Despite its importance, the impact of SARS-CoV-2 on epithelia is poorly understood. To address this, we established an model integrating epithelial Caco-2 cells, mucus-secreting HT29 cells human Raji cells. This gut allows efficient differentiation into microfold-like faithfully mimics function, highly permissive to infection. Early strains Delta variant replicated with high efficiency, severely disrupted depleted tight junction proteins, such as claudin-1, occludin ZO-1. In comparison, Omicron subvariants also ZO-1 junctions but had fewer damaging effects mucosal integrity function. Remdesivir TMPRSS2 inhibitor Camostat prevented replication thus damage, while Cathepsin E64d was ineffective. Our results support that disrupts further suggest circulating variants are less than earlier viral strains.
Язык: Английский
Процитировано
1
Journal of Medical Virology, Год журнала: 2024, Номер 96(7)
Опубликована: Июль 1, 2024
Abstract Many COVID‐19 patients suffer from gastrointestinal symptoms and impaired intestinal barrier function is thought to play a key role in Long COVID. Despite its importance, the impact of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) on epithelia poorly understood. To address this, we established an model integrating epithelial Caco‐2 cells, mucus‐secreting HT29 cells Raji cells. This gut allows efficient differentiation into microfold‐like faithfully mimics function, highly permissive SARS‐CoV‐2 infection. Early strains Delta variant replicated with high efficiency, severely disrupted depleted tight junction proteins, such as claudin‐1, occludin, ZO‐1. In comparison, Omicron subvariants also ZO‐1 junctions but had fewer damaging effects mucosal integrity function. Remdesivir, fusion inhibitor EK1 transmembrane serine protease Camostat inhibited replication thus damage, while Cathepsin E64d was ineffective. Our results support that disrupts further suggest circulating variants are less than earlier viral strains.
Язык: Английский
Процитировано
1
Neurogastroenterology & Motility, Год журнала: 2024, Номер unknown
Опубликована: Июль 22, 2024
Abstract The enteric nervous system (ENS) commands moment‐to‐moment gut functions through integrative neurocircuitry housed in the wall. functional continuity of ENS networks is disrupted neuropathies and contributes to major disturbances normal activities including abnormal motility, secretions, pain, immune dysregulation, signaling along gut–brain axis. conditions under which neuropathy occurs are diverse mechanistic underpinnings incompletely understood. purpose this brief review summarize current understanding cell types involved, occurs, mechanisms implicated such as oxidative stress, toll like receptor signaling, purines, pre‐programmed death.
Язык: Английский
Процитировано
1