Exploring the Role of PD-1 in the Autoimmune Response: Insights into Its Implication in Systemic Lupus Erythematosus

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(14), С. 7726 - 7726

Опубликована: Июль 15, 2024

Despite advances in understanding systemic lupus erythematosus (SLE), many challenges remain unraveling the precise mechanisms behind disease's development and progression. Recent evidence has questioned role of programmed cell death protein 1 (PD-1) suppressing autoreactive CD4+ T cells during autoimmune responses. Research investigated potential impacts PD-1 on various T-cell subpopulations, including follicular helper (Tfh) cells, circulating Tfh (cTfh) peripheral (Tph) all which exhibit substantial expression are closely related to several disorders, SLE. This review highlights complex autoimmunity emphasizes imperative for further research elucidate its functions Additionally, we address ligands as possible therapeutic targets

Язык: Английский

---

Exploring the Role of PD-1 in the Autoimmune Response: Insights into Its Implication in Systemic Lupus Erythematosus

Опубликована: Июнь 21, 2024

Despite advances in our knowledge of systemic lupus erythematosus (SLE) has increased over time, there are still many challenges deciphering the precise mechanisms involved development and progression disease. Recent evidence raised questions about effectiveness programmed cell death protein 1 (PD-1) suppressing autoreactive CD4+ T cells during autoimmune response. Research ventured into investigate potential impact PD-1 on various subpopulations, including follicular helper (Tfh) cells, circulating Tfh (cTfh) peripheral (Tph) all which exhibit substantial expression have been closely related with several disorders SLE. This review aims to highlight complex role autoimmunity emphasizes imperative for further research elucidate its functions T-cell Additionally, we address or ligands as a possible therapeutic target

Язык: Английский

---

Soluble form of immune checkpoints in autoimmune diseases

Journal of Autoimmunity, Год журнала: 2024, Номер 147, С. 103278 - 103278

Опубликована: Июнь 28, 2024

Язык: Английский

---

Changes in the Levels of Soluble Programmed Death Molecule-Ligand 2 (sPD-L2) in the Peripheral Blood of Systemic Lupus Erythematosus and Their Clinical Significance

Advances in Clinical Medicine, Год журнала: 2024, Номер 14(05), С. 1211 - 1222

Опубликована: Янв. 1, 2024

Язык: Английский

---