Exploring the Role of PD-1 in the Autoimmune Response: Insights into Its Implication in Systemic Lupus Erythematosus

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(14), P. 7726 - 7726

Published: July 15, 2024

Despite advances in understanding systemic lupus erythematosus (SLE), many challenges remain unraveling the precise mechanisms behind disease's development and progression. Recent evidence has questioned role of programmed cell death protein 1 (PD-1) suppressing autoreactive CD4+ T cells during autoimmune responses. Research investigated potential impacts PD-1 on various T-cell subpopulations, including follicular helper (Tfh) cells, circulating Tfh (cTfh) peripheral (Tph) all which exhibit substantial expression are closely related to several disorders, SLE. This review highlights complex autoimmunity emphasizes imperative for further research elucidate its functions Additionally, we address ligands as possible therapeutic targets

Language: Английский

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Exploring the Role of PD-1 in the Autoimmune Response: Insights into Its Implication in Systemic Lupus Erythematosus

Published: June 21, 2024

Despite advances in our knowledge of systemic lupus erythematosus (SLE) has increased over time, there are still many challenges deciphering the precise mechanisms involved development and progression disease. Recent evidence raised questions about effectiveness programmed cell death protein 1 (PD-1) suppressing autoreactive CD4+ T cells during autoimmune response. Research ventured into investigate potential impact PD-1 on various subpopulations, including follicular helper (Tfh) cells, circulating Tfh (cTfh) peripheral (Tph) all which exhibit substantial expression have been closely related with several disorders SLE. This review aims to highlight complex role autoimmunity emphasizes imperative for further research elucidate its functions T-cell Additionally, we address or ligands as a possible therapeutic target

Language: Английский

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Soluble form of immune checkpoints in autoimmune diseases

Journal of Autoimmunity, Journal Year: 2024, Volume and Issue: 147, P. 103278 - 103278

Published: June 28, 2024

Language: Английский

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Changes in the Levels of Soluble Programmed Death Molecule-Ligand 2 (sPD-L2) in the Peripheral Blood of Systemic Lupus Erythematosus and Their Clinical Significance

Advances in Clinical Medicine, Journal Year: 2024, Volume and Issue: 14(05), P. 1211 - 1222

Published: Jan. 1, 2024

Language: Английский

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