Pharmacia,
Год журнала:
2023,
Номер
70(3), С. 817 - 823
Опубликована: Сен. 19, 2023
Objective
:
The
prevalence
of
drug-related
problems
in
elderly
patients
is
a
concerning
issue
that
can
lead
to
elevated
morbidity,
mortality,
and
health
care
resource
utilisation.
This
study
focuses
on
the
significance
addressing
diabetes
context
an
ageing
population,
where
individuals
face
higher
risks
comorbidities
mortality.
main
objective
this
was
assess
potentially
inappropriate
medications
(PIMs)
potential
prescribing
omissions
(PPOs)
among
with
Bulgaria,
using
explicit
STOPP/START
criteria,
version
2.
By
evaluating
appropriateness
drug
prescriptions
specific
patient
aims
shed
light
areas
require
optimisation
enhance
safety
treatment
outcomes.
Materials
methods
A
national
prospective
questionnaire
conducted
Bulgaria
aged
over
65
years.
research
25
randomly
selected
pharmacies.
supports
use
criteria
based
clinical
information
provided.
total
133
T1DM
or
T2DM
participated
study.
evaluation
performed
131
patients.
sStatistical
differences
demographics
medication
numbers
between
without
PIMs
PPOs
were
assessed
Chi-square
test,
p-value
≤
0.05
considered
statistically
significant.
Results
pharmacotherapy
assessed,
it
found
57%
them
had
polypharmacy.
Among
90
identified,
indicating
66%
prescribing.
Notably,
associated
long-acting
sulfonylureas
(n=10)
beta-blockers
(n=13).
Applying
START
revealed
67
patients,
representing
50%
population.
However,
no
detected
pharmacotherapy.
Furthermore,
significant
relationship
observed
number
PIMs,
as
evidenced
by
chi-square
test
result
close
zero,
statistical
significance.
Conclusion
high
Bulgaria.
Endocrine
disorders
contribute
26%
PIMs.
As
Bulgaria’s
population
faces
increasing
challenges,
effective
management
strategies
are
crucial.
These
findings
underscore
practises
disease
control
prevent
complications.
Therapies,
Год журнала:
2023,
Номер
78(5), С. 575 - 584
Опубликована: Фев. 9, 2023
To
assess
the
prevalence
of
potentially
inappropriate
medications
(PIMs)
and
polypharmacy
in
adults
aged
75
years
over
France
2019
based
on
data
from
French
health
insurance
claims
database,
at
national
level
by
region.
We
conducted
a
cross-sectional
study
or
2019.
assessed
seventeen
PIM
criteria
adapted
2015
Beers
STOPP
lists,
as
well
cumulative
polypharmacy.
Polypharmacy
(5
to
9
drugs)
hyper-polypharmacy
(≥10
were
defined
average
number
drugs
dispensed
per
quarter.
The
regional
analysis
used
age-
sex-standardized
prevalence.
Of
6,707,897
older
adults,
39.6%
exposed
least
one
2019,
46.7%
drugs),
25.2%
drugs).
Benzodiazepine
PIMs
most
frequent
(26.9%),
followed
atropinic
(8.3%),
non-steroidal
anti-inflammatory
(7.8%),
concomitant
use
three
more
central
nervous
system-active
(7.3%),
antihypertensive
(6.0%).
There
was
gradient
exposure
according
for
every
category.
observed
variations
prevalence,
36.5%
Pays-de-la-Loire
44.8%
Hauts-de-France
mainland
France.
These
results
show
that
concerned
than
after
age
support
need
secure
medication
this
population.
reasons
geographic
should
be
investigated
further
studies.
British Journal of Clinical Pharmacology,
Год журнала:
2024,
Номер
90(6), С. 1376 - 1394
Опубликована: Фев. 26, 2024
The
aim
of
this
study
was
to
estimate
the
prevalence
potentially
inappropriate
prescriptions
(PIPs)
in
patients
starting
their
first
noninsulin
antidiabetic
treatment
(NIAD)
using
two
explicit
process
measures
appropriateness
prescribing
UK
primary
care,
stratified
by
age
and
polypharmacy
status.
Pharmacoepidemiology and Drug Safety,
Год журнала:
2022,
Номер
31(10), С. 1056 - 1074
Опубликована: Июль 3, 2022
Potentially
inappropriate
medications
(PIMs)
are
contra-indicated
in
particular
circumstances.
We
sought
to
characterize
PIMs
by
level
of
polypharmacy
age,
sex,
and
race/ethnicity.We
performed
a
cross-sectional
drug
dispensing
study
using
electronic
health
records
available
through
the
US
Department
Veterans
Affairs.
extracted
pharmacy
fill
refill
during
fiscal
year
2016
(i.e.,
October
1,
2015-September
30,
2016)
for
all
patients
aged
49-70
who
accessed
care
preceding
year.
were
defined
combined
Beers
Laroche
(henceforth
Laroche)
criteria
used
older
PROMPT
middle-aged.In
1
499
586
49-64,
prevalence
with
0-4,
5-9,
≥10
was
14.0%,
62.2%,
86.1%,
respectively,
14.3%,
63.4%,
85.7%,
respectively.
In
249
119
65-70,
14.8%,
59.9%,
83.3%,
13.9%,
57.4%,
82.0%,
Meaningful
differences
shown
sex
race/ethnicity
according
both
set
(e.g.
5-9
medications:
66.1%
women
vs.
59.3%
men;
standardized-mean-differences
[SMD]
=
0.14;
61.7%
White
54.5%
non-White;
SMD
0.15).
The
most
common
digestive,
analgesic,
antidiabetic,
psychotropic
medications.Prevalence
high
increased
polypharmacy.
provided
similar
estimations
inside
outside
their
target
suggesting
that
among
those
regardless
age.
Expert Review of Pharmacoeconomics & Outcomes Research,
Год журнала:
2021,
Номер
22(4), С. 627 - 636
Опубликована: Сен. 16, 2021
Potentially
inappropriate
prescriptions
(PIPs)
in
the
older
population
remain
a
growing
public
health
concern
due
to
many
associated
adverse
events
increasing
healthcare
service
use
and
costs.
This
study
aimed
assess
prevalence
direct
costs
of
PIPs
adults
aged
≥65
years
France.A
population-based
cross-sectional
was
conducted
2017
using
representative
sample
French
national
reimbursement
system
database.
were
defined
REMEDI[e]S
tool.
Overall
reimbursed
by
PIP
category
extrapolated
population.The
overall
estimated
at
56.7%
(95%
CI:
56.4-57.0).
Medications
with
an
unfavorable
benefit/risk
ratio
had
highest
(34.0%,
95%
33.7-34.3).
Direct
represented
6.3%
total
medication
(€507
million).
Drug
duplications
main
contributors
these
(39.2%
costs,
€199
million)
among
all
PIPs,
proton
pump
inhibitors
(>8
weeks)
most
expensive
(€152
million).PIP
is
still
high
adults,
substantial
Large-scale
interventions
targeting
prevalent
and/or
costly
are
needed
reduce
their
clinical
economic
impacts.
