Immunomodulatory and bone regenerative properties of copper/procyanidins-modified titanium surfaces

Biomaterials Advances, Год журнала: 2025, Номер 169, С. 214199 - 214199

Опубликована: Янв. 23, 2025

Язык: Английский

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Magnetic-responsive materials tailored to enhance the cascade of bone regeneration and immune response

Materials & Design, Год журнала: 2025, Номер unknown, С. 113645 - 113645

Опубликована: Янв. 1, 2025

Язык: Английский

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Material‐Mediated Immunotherapy to Regulate Bone Aging and Promote Bone Repair

Small, Год журнала: 2025, Номер unknown

Опубликована: Фев. 21, 2025

Abstract As the global population ages, an increasing number of elderly people are experiencing weakened bone regenerative capabilities, resulting in slower repair processes and associated risks various complications. This review outlines research progress on biomaterials that promote through immunotherapy. examines how manufacturing technologies such as 3D printing, electrospinning, microfluidic technology contribute to enhancing therapeutic effects these biomaterials. Following this, it provides detailed introductions anti‐osteoporosis drug delivery systems, injectable hydrogels, nanoparticles, engineered exosomes, well tissue engineering materials coatings used immunomodulation. Moreover, critically analyzes current limitations biomaterial‐mediated immunotherapy explores future directions for material‐mediated aims inspire new approaches broaden perspectives addressing challenges aging by exploring innovative strategies.

Язык: Английский

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Rapid osteoinduction of human adipose-derived stem cells grown on bioactive surfaces and stimulated by chemically modified media flow

Journal of Biological Engineering, Год журнала: 2025, Номер 19(1)

Опубликована: Март 14, 2025

Abstract Adipose-derived stem cells (ASCs) provide an ample, easily accessible source of multipotent cells, alternative to bone marrow-derived stromal (BMSCs), capable differentiating into osteoblasts. However, the osteogenic potential ASCs is reportedly lower than that BMSCs and protocols effectively differentiate osteoblasts are in high demand. Here, we present novel strategies for effective differentiation human by combining their culture on bioactive growth surfaces with treatment specific supplements medium application fluid shear stress. Human were cultured PLGA-based composites containing 50 wt% sol-gel glasses (SBGs) from SiO 2 -CaO±P O 5 system, either unmodified or modified ZnO SrO. The was supplemented recombinant morphogenetic protein (BMP-2), MEK1/2 kinase inhibitor (PD98059) indirect Smurf1 (Phenamil). Fluid stress applied a standard horizontal rocker. ASC SBG-PLGA along enhanced expression both early late markers. Modification SBG SrO further gene compared SBGs. Notably, synergistically strengthened effects supplements. We also show presented can drive toward osteoblastic 3-day period mineralizing through short, 7-day preculture composites. Our results indicate leads phosphorylation β-catenin CREB COX-2 expression. believe feasible rapid various cell-based regeneration therapies. Graphical

Язык: Английский

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Cellulose nanocrystals vs. cellulose nanospheres: A comparative study of cytotoxicity and macrophage polarization potential

Carbohydrate Polymers, Год журнала: 2022, Номер 303, С. 120464 - 120464

Опубликована: Дек. 14, 2022

Язык: Английский

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Nanomaterial-based drug delivery of immunomodulatory factors for bone and cartilage tissue engineering

Biomaterials Advances, Год журнала: 2023, Номер 154, С. 213637 - 213637

Опубликована: Сен. 23, 2023

As life expectancy continues to increase, so do disorders related the musculoskeletal system. Orthopedics-related impairments remain a challenge, with nearly 325 thousand and 120 deaths recorded in 2019. Musculoskeletal system, including bone cartilage tissue, is living system which cells constantly interact immune plays key role tissue repair process. An alternative bridge gap between these two systems exploiting nanomaterials, as they have proven serve delivery agents of an array molecules, immunomodulatory (anti-inflammatory drugs, cytokines), well having ability mimic by their nanoscopic structure promote per se. Therefore, this review outlooks nanomaterials factors widely employed area engineering. Emerging developments for engineering applications also been discussed. It can be concluded that latest progress nanotechnology enabled design intricate deliver biologically active agents, promoting regeneration; thus, studied herein shown great potential

Язык: Английский

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Biphasic bone substitutes coated with PLGA incorporating therapeutic ions Sr2+ and Mg2+: cytotoxicity cascade and in vivo response of immune and bone regeneration

Frontiers in Bioengineering and Biotechnology, Год журнала: 2024, Номер 12

Опубликована: Июнь 24, 2024

The incorporation of bioactive ions into biomaterials has gained significant attention as a strategy to enhance bone tissue regeneration on the molecular level. However, little knowledge exists about effects addition these immune response and especially most important cellular regulators, macrophages. Thus, this study aimed investigate in vitro cytocompatibility vivo regulation remodeling material-related responses biphasic substitute (BBS) coated with metal (Sr 2+ /Mg ) PLGA, using pure BBS control group. Initially, two cytocompatible modified material variants were identified according results obtained following DIN EN ISO 10993-5 protocol. surface structure ion release both materials characterized SEM-EDX ICP-OES. then implanted Wistar rats for 10, 30, 90 days cranial defect model. Histopathological histomorphometrical analyses applied evaluate degradation, regeneration, osteoconductivity, response. findings revealed that all groups comparable new formation found. during early implantation period, BBS_Sr group exhibited significantly faster compared other groups. Additionally, induced involving high numbers pro-inflammatory macrophages multinucleated giant cells (MNGCs). In conclusion, delved repercussions therapeutic doping patterns inflammatory responses, offering insights advancement generation calcium phosphate potential clinical applicability.

Язык: Английский

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Integrating Micro- and Nanostructured Platforms and Biological Drugs to Enhance Biomaterial-Based Bone Regeneration Strategies

Biomacromolecules, Год журнала: 2024, Номер 26(1), С. 140 - 162

Опубликована: Дек. 2, 2024

Bone defects resulting from congenital anomalies and trauma pose significant clinical challenges for orthopedics surgeries, where bone tissue engineering (BTE) aims to address these by repairing that fail heal spontaneously. Despite numerous advances, BTE still faces several challenges, i.e., difficulties in detecting tracking implanted cells, high costs, regulatory approval hurdles. Biomaterials promise revolutionize grafting procedures, heralding a new era of regenerative medicine advancing patient outcomes worldwide. Specifically, novel bioactive biomaterials have been developed promote cell adhesion, proliferation, differentiation osteoconductive osteoinductive characteristics, stimulating regeneration repair, particularly complex skeletal caused trauma, degeneration, neoplasia. A wide array biological therapeutics emerged, drawing the diverse spectrum gene therapy, immune interactions, RNA molecules. This review will provide insights into current state potential future strategies regeneration.

Язык: Английский

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Functional Hydrogel Empowering 3D Printing Titanium Alloys

Materials Today Bio, Год журнала: 2024, Номер 30, С. 101422 - 101422

Опубликована: Дек. 24, 2024

Язык: Английский

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The role of toll-like receptors in orchestrating osteogenic differentiation of mesenchymal stromal cells and osteoimmunology

Frontiers in Cell and Developmental Biology, Год журнала: 2023, Номер 11

Опубликована: Окт. 23, 2023

Osteoimmunology is a concept involving molecular and cellular crosstalk between the skeletal immune systems. Toll-like receptors (TLRs) are widely expressed both on mesenchymal stromal cells (MSCs), hematopoietic cells, in osteogenic microenvironment for bone development or repair. TLRs can sense exogenous pathogen-associated patterns (PAMPs) derived from microorganisms, damage-associated (DAMPs) normal subjected to injury, inflammation, cell apoptosis under physiological pathological conditions. Emerging studies reported that TLR signaling plays an important role remodeling by directly impacting MSC differentiation osteoimmunology. However, how regulate critical remains be elucidated promote of MSCs new formation tissue This review outlines distinct variants various tissues, detailing impact pathway activation inhibition differentiation. It also elucidates pathways’ interplay with osteoclasts, extracellular vesicles (EVs) MSCs. Furthermore, we explore biomaterial-based guide MSCs’ Therefore, understanding TLRs’ this context has significant implications advancing regeneration repair strategies.

Язык: Английский

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