In
vitro
testing
is
the
first
important
step
in
development
of
new
biomaterials.
The
human
fetal
osteoblast
cell
line
hFOB
1.19
a
very
promising
model;
however,
there
are
vast
discrepancies
cultivation
protocols,
especially
temperature
and
presence
selection
reagent,
geneticin
(G418).
We
intended
to
use
for
Zn-based
degradable
metallic
materials.
However,
sensitivity
zinc
ions
has
not
yet
been
studied.
Therefore,
we
compared
toxicity
towards
under
different
conditions
it
with
that
L929
mouse
fibroblast
line.
also
tested
cytotoxicity
three
types
biomaterials
two
media.
G418
used
as
reagent
decreased
Zn2+.
were
more
sensitive
Zn2+
at
elevated
(restrictive)
temperatures.
less
than
(both
ZnCl2
extracts
alloys).
appropriate
during
biomaterial
should
be
chosen
caution.
Pharmaceutics,
Год журнала:
2023,
Номер
15(2), С. 313 - 313
Опубликована: Янв. 17, 2023
3D
printing
technologies
enable
medicine
customization
adapted
to
patients'
needs.
There
are
several
techniques
available,
but
majority
of
dosage
forms
and
medical
devices
printed
using
nozzle-based
extrusion,
laser-writing
systems,
powder
binder
jetting.
has
been
demonstrated
for
a
broad
range
applications
in
development
targeting
solid,
semi-solid,
locally
applied
or
implanted
medicines.
3D-printed
solid
allow
the
combination
one
more
drugs
within
same
form
improve
patient
compliance,
facilitate
deglutition,
tailor
release
profile,
fabricate
new
medicines
which
no
is
available.
Sustained-release
implants,
stents,
have
used
mainly
joint
replacement
therapies,
prostheses,
cardiovascular
applications.
Locally
medicines,
such
as
wound
dressing,
microneedles,
medicated
contact
lenses,
also
manufactured
techniques.
The
challenge
select
technique
most
suitable
each
application
type
pharmaceutical
ink
that
should
be
developed
possesses
required
physicochemical
biological
performance.
integration
biopharmaceuticals
nanotechnology-based
along
with
("nanoprinting")
brings
personalized
nanomedicines
innovative
perspectives
coming
years.
Continuous
manufacturing
through
use
microfluidic
chips
facilitates
their
translation
into
clinical
practice.
Corrosion Science,
Год журнала:
2024,
Номер
239, С. 112399 - 112399
Опубликована: Авг. 24, 2024
Zn-Mn
alloys
are
considered
promising
biodegradable
metals
for
orthopedic
applications
due
to
their
large
elongation
and
favorable
osteogenicity.
However,
the
corrosion
rate
of
could
be
improved
meet
degradation
requirement
implants.
In
this
study,
a
Zn-1.5Mn
alloy
was
prepared
via
high-pressure
solid-solution
(HPSS)
treatment
at
5
GPa
380
°C
1
h
cast
ingots.
Microstructural
evaluation
revealed
HPSS
caused
phase
transition
from
ζ-MnZn13
an
ε-MnZn3
phase.
The
electrode
potential
difference
between
α-Zn
significantly
larger
than
α-Zn,
leading
accelerated
HPSS-treated
alloy.
It
showed
electrochemical
0.343
mm/y
immersion
0.028
mm/y,
while
as-cast
(AC)
displayed
0.216
0.026
mm/y.
Further,
exhibited
compressive
yield
strength
202
MPa
microhardness
83.48
HV.
addition,
cell
viability
toward
human
umbilical
vein
endothelial
cells
(HUVEC)
comparable
its
AC
atmospheric
pressure
solid-solution-treated
(APSS-treated)
counterparts
HUVEC,
along
with
antibacterial
activity.
Materials,
Год журнала:
2023,
Номер
16(13), С. 4797 - 4797
Опубликована: Июль 3, 2023
Zinc
(Zn)-based
biodegradable
materials
show
moderate
degradation
rates
in
comparison
with
other
(Fe
and
Mg).
Biocompatibility
non-toxicity
also
make
them
a
viable
option
for
implant
applications.
Furthermore,
Pure
Zn
has
poor
mechanical
behavior,
tensile
strength
of
around
100–150
MPa
an
elongation
0.3–2%,
which
is
far
from
reaching
the
required
as
orthopedic
material
(tensile
more
than
300
MPa,
15%).
Alloy
composite
fabrication
have
proven
to
be
excellent
ways
improve
performance
Zn.
Therefore,
their
alloys
composites
emerged
innovative
category
materials.
This
paper
summarizes
most
important
recent
research
results
on
biological
characteristics
Zn-based
implants
applications
commonly
added
components
composites.
Journal of Functional Biomaterials,
Год журнала:
2023,
Номер
14(3), С. 159 - 159
Опубликована: Март 16, 2023
The
goal
of
this
review
is
to
map
the
current
state
biodegradable
materials
that
are
used
in
tissue
engineering
for
a
variety
applications.
At
beginning,
paper
briefly
identifies
typical
clinical
indications
orthopedics
use
implants.
Subsequently,
most
frequent
groups
identified,
classified,
and
analyzed.
To
end,
bibliometric
analysis
was
applied
evaluate
evolution
scientific
literature
selected
topics
subject.
special
focus
study
on
polymeric
have
been
widely
regenerative
medicine.
Moreover,
outline
research
trends
future
directions
area,
smart
characterized,
categorized,
discussed.
Finally,
pertinent
conclusions
regarding
applicability
drawn
recommendations
suggested
drive
line
forward.
Cells,
Год журнала:
2023,
Номер
12(9), С. 1230 - 1230
Опубликована: Апрель 24, 2023
The
skeletal
system
is
a
key
support
structure
within
the
body.
Bones
have
unique
abilities
to
grow
and
regenerate
after
injury.
Some
injuries
or
degeneration
of
tissues
cannot
rebound
must
be
repaired
by
implantation
foreign
objects
following
injury
disease.
This
process
invasive
does
not
always
improve
quality
life
patient.
New
techniques
arisen
that
can
bone
replacement
repair.
3D
bioprinting
employs
printer
capable
printing
biological
materials
in
multiple
directions.
potentially
requires
steps
additional
structures,
which
may
include
use
hydrogels
for
scaffolding.
In
this
review,
we
discuss
normal
physiology
pathophysiology
how
adapted
further
field
tissue
engineering.
Heliyon,
Год журнала:
2024,
Номер
10(12), С. e32713 - e32713
Опубликована: Июнь 1, 2024
Mg-based
and
Zn-based
biodegradable
materials
have
the
potential
to
become
next-generation
implant
treat
bone
diseases,
because
of
their
desired
degradation
mechanical
properties.
This
article
reviews
status
these
materials.
The
required
properties
such
as
biodegradability,
properties,
biocompatibility
for
performance
evaluation
were
briefly
discussed.
influence
fabrication
techniques,
microstructure,
alloying
elements,
post-processing
techniques
on
Mg
was
addressed.
mechanism
by
dissolution,
oxidation,
interaction
with
human
body
cells
analyzed.
significance
in
vitro
vivo
testing
highlighted,
emphasizing
superiority
results
over
cell
line
studies.
identifies
many
summarizes
key
findings.
Journal of Materials Research and Technology,
Год журнала:
2023,
Номер
26, С. 3025 - 3053
Опубликована: Авг. 14, 2023
High-temperature
resistant
material
is
becoming
increasingly
significant
in
numerous
industrial
applications,
including
aerospace
and
automotive
use,
to
increase
fuel
efficiency
decrease
CO2
emissions.
Metals
with
nanoparticles
form
metal
matrix
nanocomposite
(MMNCs)
are
promising
enhance
metals
for
structural/industrial
applications
at
high
temperatures.
This
review
provides
a
comprehensive
insight
into
the
nanoparticle
effect
on
creep
behavior
of
alloys.
Firstly,
it
discusses
different
mechanisms
that
activated
response
strain
according
deformation
parameters
(temperature,
load,
microstructure).
The
most
vary
grain
shape
accommodation
mechanism
required
facilitate
boundary
sliding
by
diffusion
intragranular
dislocation
activity.
Secondly,
reviews
threshold
stress
contribution
composites
as
well
load
transfer
phenomenon,
which
enhances
resistance
nanoparticles.
Thirdly,
nanoparticles'
influences
metals,
especially
Al,
Mg,
Ti,
Zn,
solder
alloys,
reviewed
detail.
Finally,
summary
this
future
aspects
associated
temperatures
provided.
