In
vitro
testing
is
the
first
important
step
in
development
of
new
biomaterials.
The
human
fetal
osteoblast
cell
line
hFOB
1.19
a
very
promising
model;
however,
there
are
vast
discrepancies
cultivation
protocols,
especially
temperature
and
presence
selection
reagent,
geneticin
(G418).
We
intended
to
use
for
Zn-based
degradable
metallic
materials.
However,
sensitivity
zinc
ions
has
not
yet
been
studied.
Therefore,
we
compared
toxicity
towards
under
different
conditions
it
with
that
L929
mouse
fibroblast
line.
also
tested
cytotoxicity
three
types
biomaterials
two
media.
G418
used
as
reagent
decreased
Zn2+.
were
more
sensitive
Zn2+
at
elevated
(restrictive)
temperatures.
less
than
(both
ZnCl2
extracts
alloys).
appropriate
during
biomaterial
should
be
chosen
caution.
ACS Omega,
Год журнала:
2023,
Номер
8(31), С. 27920 - 27931
Опубликована: Июль 26, 2023
Bone
fractures
have
always
been
a
burden
to
patients
due
their
common
occurrence
and
severe
complications.
Traditionally,
operative
treatments
widely
used
in
the
clinic
for
implanting,
despite
fact
that
they
can
only
achieve
bone
fixation
with
limited
stability
pose
no
effect
on
promoting
tissue
growth.
In
addition,
nondegradable
implants
usually
need
secondary
surgery
implant
removal,
otherwise
may
block
regeneration
of
bones
resulting
nonunion.
To
overcome
low
degradability
avoid
multiple
surgeries,
engineers
investigated
various
biodegradable
materials
regeneration,
whereas
significance
long-term
tends
be
neglected
during
this
process.
Combining
traditional
orthopedic
implantation
surgeries
emerging
engineering,
we
believe
both
are
indispensable
factors
successful
repair.
Herein,
define
such
novel
idea
as
regenerative
(BRF),
which
should
main
future
development
trend
materials.
Journal of Functional Biomaterials,
Год журнала:
2022,
Номер
14(1), С. 1 - 1
Опубликована: Дек. 20, 2022
Zn-based
biodegradable
alloys
or
composites
have
the
potential
to
be
developed
next-generation
orthopedic
implants
as
alternatives
conventional
avoid
revision
surgeries
and
reduce
biocompatibility
issues.
This
review
summarizes
current
research
status
on
materials.
The
biological
function
of
Zn,
design
criteria
for
implants,
corrosion
behavior
materials
are
briefly
discussed.
performance
many
novel
zinc-based
is
evaluated
in
terms
biodegradation,
biocompatibility,
mechanical
properties.
perform
a
significant
role
bone
metabolism
growth
new
cells
show
medium
degradation
without
release
excessive
hydrogen.
addition
alloying
elements
such
Mg,
Zr,
Mn,
Ca,
Li
into
pure
Zn
enhances
properties
alloys.
Grain
refinement
by
application
post-processing
techniques
effective
development
suitable
Materials Today Bio,
Год журнала:
2023,
Номер
24, С. 100885 - 100885
Опубликована: Дек. 1, 2023
Additively
manufactured
biodegradable
zinc
(Zn)
scaffolds
have
great
potential
to
repair
infected
bone
defects
due
their
osteogenic
and
antibacterial
properties.
However,
the
enhancement
of
properties
depends
on
a
high
concentration
dissolved
Zn
ACS Applied Engineering Materials,
Год журнала:
2023,
Номер
1(2), С. 734 - 743
Опубликована: Янв. 31, 2023
Zinc
alloys
have
emerged
as
promising
biodegradable
metals
thanks
to
their
critical
physiological
roles
and
encouraging
degradation
behavior.
In
this
study,
calcium
phosphate
(CaP)
coatings
were
made
on
micro-arc
oxidized
Zn
alloy
using
hydrothermal
treatment
(HT),
which
was
motivated
by
the
CaP-based
minerals
in
natural
bone
tissue.
The
coating
morphology
optimized
controlling
HT
time,
resulting
a
homogeneous
micro-CaP
structure.
CaP
significantly
increased
cell
viability
adhesion
of
MC3T3-E1
preosteoblasts
L-929
cells.
Compared
with
control
group,
toxicity
samples
after
MAO-HT
less,
number
cells
more,
complete.
Cell
showed
that
distribution
increase
time.
addition,
reduced
ion
release
from
bulk
material
during
process,
much
lower
concentration
pH
change
surrounding
environment.
structure
regulated
zinc
ions
are
primarily
responsible
for
enhanced
cytocompatibility
biomineralization
CaP-coated
biomaterials.
summary,
Zn-based
biomaterial
appears
be
viable
approach
enhance
its
biocompatibility
rate.
After
that,
can
improved
surface
adapt
complex
human
Biodegradable
zinc-based
alloys
are
regarded
as
a
promising
avenue
of
research
for
the
development
bone
fixation
implants,
offering
potential
solutions
to
clinical
issues,
such
stress
shielding,
secondary
surgeries,
and
biocompatibility.
In
this
study,
Zn-0.8Li-0.4Mg
alloy
was
designed
fabricated
its
use
implant
evaluated.
The
displays
an
ultimate
tensile
strength
450
MPa
elongation
18%,
thereby
satisfying
requisite
mechanical
specifications
implants.
results
electrochemical
SBF
in
vitro
corrosion
tests
indicate
that
degradation
mechanism
evolves
over
time.
initial
product
layer
is
composed
dense
Li-containing
(LiOH/Li2CO3),
which
subsequently
transforms
into
Mg-containing
(MgO/Mg(OH)2)
progresses.
Ultimately,
due
depletion
Li
erosion
by
Cl-,
it
transitions
containing
only
Zn
Ca/P
layer.
overall
jointly
determined
degree
local
resistance
Cytotoxicity
demonstrate
exhibits
favorable
ACS Applied Materials & Interfaces,
Год журнала:
2023,
Номер
15(42), С. 48913 - 48929
Опубликована: Окт. 17, 2023
Zinc
(Zn)
metal
and
its
alloys
have
received
a
lot
of
interest
in
biomedical
applications
due
to
their
biodegradability,
biocompatibility,
antimicrobial
activity,
ability
stimulate
tissue
regeneration.
Bulk
Zn
has
been
successfully
utilized
variety
implant
applications,
most
notably
as
bioabsorbable
cardiac
stents
orthopedic
fixation
devices,
where
it
provides
adequate
mechanical
properties
while
also
releasing
helpful
ions
(Zn2+)
during
degradation.
Such
beneficial
are
dose-dependent
and,
when
released
excess,
can
induce
cellular
toxicity.
In
this
study,
we
hypothesize
that
embedding
particles
into
polymer
nanofibrous
scaffold
will
enable
control
the
degradation
time
release
Zn2+.
We
designed
fabricated
two
scaffolds,
polycaprolactone
(PCL)
polycaprolactone-chitosan
(PCL-CH).
Each
had
an
increasing
amount
Zn.
Several
physicochemical
such
fiber
morphology,
crystallinity,
strength,
hydrophilicity,
Zn2+,
thermal
properties,
chemical
compositions,
so
forth
were
characterized
compared
with
PCL
fibrous
scaffold.
The
biological
scaffolds
evaluated
vitro
utilizing
direct
indirect
cytotoxicity
assays
cell
viability.
All
data
show
addition
changed
various
physical
PCL-CH
except
structure.
Further
investigation
reveals
degrade
relatively
faster
than
because
presence
hydrophilic
CH
influences
Zn2+
culture
conditions
combined
advantages
enriched
3T3
fibroblast
cells'
survival
proliferation
ones
higher
concentration
particles.
These
new
composite
promising
be
further
considered
for
healing
regeneration
applications.
