Bridging Nanomanufacturing and Artificial Intelligence—A Comprehensive Review
Materials,
Год журнала:
2024,
Номер
17(7), С. 1621 - 1621
Опубликована: Апрель 2, 2024
Nanomanufacturing
and
digital
manufacturing
(DM)
are
defining
the
forefront
of
fourth
industrial
revolution—Industry
4.0—as
enabling
technologies
for
processing
materials
spanning
several
length
scales.
This
review
delineates
evolution
nanomaterials
nanomanufacturing
in
age
applications
medicine,
robotics,
sensory
technology,
semiconductors,
consumer
electronics.
The
incorporation
artificial
intelligence
(AI)
tools
to
explore
nanomaterial
synthesis,
optimize
processes,
aid
high-fidelity
nanoscale
characterization
is
discussed.
paper
elaborates
on
different
machine-learning
deep-learning
algorithms
analyzing
images,
designing
nanomaterials,
nano
quality
assurance.
challenges
associated
with
application
machine-
models
achieve
robust
accurate
predictions
outlined.
prospects
incorporating
sophisticated
AI
such
as
reinforced
learning,
explainable
(XAI),
big
data
analytics
material
process
innovation,
nanosystem
integration
Язык: Английский
3D Printing of Biodegradable Polymeric Microneedles for Transdermal Drug Delivery Applications
Pharmaceutics,
Год журнала:
2024,
Номер
16(2), С. 237 - 237
Опубликована: Фев. 6, 2024
Microneedle
(MN)
technology
is
an
optimal
choice
for
the
delivery
of
drugs
via
transdermal
route,
with
a
minimally
invasive
procedure.
MN
applications
are
varied
from
drug
delivery,
cosmetics,
tissue
engineering,
vaccine
and
disease
diagnostics.
The
biomedical
device
that
offers
many
advantages
including
but
not
limited
to
painless
experience,
being
time-effective,
real-time
sensing.
This
research
implements
additive
manufacturing
(AM)
fabricate
arrays
advanced
therapeutic
applications.
Stereolithography
(SLA)
was
used
six
designs
three
aspect
ratios.
array
included
conical-shaped
100
needles
(10
×
10
needle)
in
each
array.
microneedles
were
characterized
using
optical
scanning
electron
microscopy
evaluate
dimensional
accuracy.
Further,
mechanical
insertion
tests
performed
analyze
strength
skin
penetration
capabilities
polymeric
MN.
MNs
higher
ratios
had
deformation
characteristics
suitable
deeper
levels
beyond
stratum
corneum.
both
0.3
mm
0.4
base
diameters
displayed
consistent
force–displacement
behavior
during
skin-equivalent
test.
establishes
guidelines
fabricating
high-accuracy
low-cost
3D
printing.
Язык: Английский
A Janus nanofibrous scaffold integrated with exercise-driven electrical stimulation and nanotopological effect enabling the promotion of tendon-to-bone healing
Nano Today,
Год журнала:
2024,
Номер
55, С. 102208 - 102208
Опубликована: Фев. 29, 2024
Язык: Английский
Bioinspired synthesis and characterization of zinc oxide nanoparticles and assessment of their cytotoxicity and antimicrobial efficacy
Deleted Journal,
Год журнала:
2024,
Номер
6(3)
Опубликована: Фев. 21, 2024
Abstract
Zinc
oxide
nanoparticles
(ZnO
NPs)
are
versatile
and
promising,
with
diverse
applications
in
environmental
remediation,
nanomedicine,
cancer
treatment,
drug
delivery.
In
this
study,
ZnO
NPs
were
synthesized
utilizing
extracts
derived
from
Acacia
catechu,
Artemisia
vulgaris
,
Cynodon
dactylon
.
The
showed
an
Ultraviolet–visible
spectrum
at
370
nm,
X-ray
diffraction
analysis
indicated
the
hexagonal
wurtzite
framework
average
crystallite
size
of
15.07
16.98
18.97
nm
for
A.
vulgaris,
C.
respectively.
Scanning
electron
microscopy
(SEM)
demonstrated
spherical
surface
morphology
diameters
18.5
17.82
17.83
prepared
dactylon,
Furthermore,
tested
against
Staphylococcus
aureus,
Kocuria
rhizophila,
Klebsiella
pneumonia,
Shigella
sonnei
a
zone
inhibition
8
to
14
mm.
cell
viability
cytotoxicity
effects
studied
on
NIH-3T3
mouse
fibroblast
cells
treated
different
concentrations
(5
μg/mL,
10
50
μg/mL).
results
biocompatibility
all
samples,
except
higher
doses
causing
death.
conclusion,
through
plant-mediated
technique
promise
potential
utilization
various
biomedical
future.
Язык: Английский
Zein-Coated Zn Metal Particles-Incorporated Nanofibers: A Potent Fibrous Platform for Loading and Release of Zn Ions for Wound Healing Application
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(37), С. 49197 - 49217
Опубликована: Сен. 5, 2024
Metal
particles
incorporated
into
polymer
matrices
in
various
forms
and
geometries
are
attractive
material
platforms
for
promoting
wound
healing
preventing
infections.
However,
the
fate
of
these
metal
their
degraded
products
tissue
environment
still
unknown,
as
both
can
produce
cytotoxic
effects
promote
unwanted
reactions.
In
this
study,
we
develop
biodegradable
fibrous
biomaterials
embedded
with
that
have
an
immune
activation
functions.
Initially,
zinc
(Zn)
nanoparticles
were
modified
zein
(G),
a
protein
derived
from
corn.
The
zein-coated
(Z-G)
then
polycaprolactone
(P)
fibers
at
different
weight
ratios
to
create
via
electrospinning,
which
subsequently
analyzed
potential
applications.
We
performed
multimodal
evaluations
scaffolds,
examining
physicochemical
properties
such
fiber
morphology,
mechanical
strength,
hydrophilicity,
degradation,
release
ions
(Zn
Язык: Английский
The 3D Printing of Nanocomposites for Wearable Biosensors: Recent Advances, Challenges, and Prospects
Bioengineering,
Год журнала:
2023,
Номер
11(1), С. 32 - 32
Опубликована: Дек. 27, 2023
Notably,
3D-printed
flexible
and
wearable
biosensors
have
immense
potential
to
interact
with
the
human
body
noninvasively
for
real-time
continuous
health
monitoring
of
physiological
parameters.
This
paper
comprehensively
reviews
progress
in
biosensors.
The
review
also
explores
incorporation
nanocomposites
3D
printing
A
detailed
analysis
various
processes
fabricating
is
reported.
Besides
this,
recent
advances
platforms
such
as
sweat
sensors,
glucose
electrocardiography
electroencephalography
tactile
oximeters,
tattoo
respiratory
sensors
are
discussed.
Furthermore,
challenges
prospects
associated
presented.
an
invaluable
resource
engineers,
researchers,
healthcare
clinicians,
providing
insights
into
advancements
capabilities
biosensor
domain.
Язык: Английский
Enhanced Cell Proliferation, Migration, and Fibroblast Differentiation with Electrospun PCL–Zinc Scaffolds Coated with Fibroblast-Derived ECM
ACS Omega,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 28, 2025
Despite
tremendous
improvement
in
the
development
of
tissue-regenerating
materials,
a
promising
solution
that
provides
an
optimal
environment
remains
to
be
accomplished.
Here,
we
report
composite
nanofiber
biomaterial
scaffold
as
closely
mimics
extracellular
matrix
(ECM)
improve
cell
viability,
proliferation,
and
migration.
Initially,
composites
polycaprolactone
(PCL)
zinc
(Zn)
metal
were
fabricated
by
using
electrospinning.
The
resulting
PCL–Zn
(PZ)
nanofibers
effectively
guided
growth
NIH3T3
fibroblasts
for
7
days,
forming
fibroblast
sheet.
PZ
fibers
decellularized
remove
autologous
allogenic
cellular
antigens
while
leaving
intact
ECM
with
structural
functional
components.
PCL–Zn–ECM
(PZE)
showcased
natural
bonded
surface,
providing
bioactive
element
interconnected
fibers.
reseeding
demonstrated
scaffold's
excellent
capacity
direct
support
proliferation.
Furthermore,
vitro
cytotoxicity
analysis
morphological
staining
confer
biocompatibility.
PZE
presents
which
these
scaffolds
can
further
used
various
regenerative
medicine
applications
including
wound
healing.
Язык: Английский
Designed Biomaterial‐Enhanced Cell Transplantation for Neural Tissue Engineering
Aggregate,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 7, 2025
ABSTRACT
Cell
transplantation
therapy
in
the
central
nervous
system
is
hindered
by
limited
survival
and
integration
of
grafted
cells.
Biomaterials
have
emerged
as
an
attractive
solution
to
this
problem
providing
a
protective
microenvironment
deliver
cells
injured
tissues.
The
design
biomaterials
compatible
with
tissues
promote
tissue
repair
functional
recovery
focus
neural
engineering.
A
wealth
research
has
explored
different
materials
architectures
combination
bioactive
cues
glial
cell
growth
maturation.
After
brief
presentation
biomaterial
strategies
sources,
we
review
vivo
evidences
about
efficacy
stem
cotransplantation
(i)
enhancing
trophic
effects,
(ii)
increasing
integration,
(iii)
achieving
preclinical
models
stroke,
traumatic
brain
injury,
Parkinson's
disease,
spinal
cord
injury.
Furthermore,
comprehensive
perspective
was
offered
regarding
specific
implementation
tactics,
obstacles,
development
orientations
employing
critical
support
transplantation.
Язык: Английский
Electrospun Polycaprolactone–Gelatin Fibrils Enabled 3D Hydrogel Microcapsules for Biomedical Applications
Journal of Functional Biomaterials,
Год журнала:
2025,
Номер
16(3), С. 85 - 85
Опубликована: Март 2, 2025
Microcapsules
provide
a
microenvironment
by
improving
the
protection
and
delivery
of
cells
drugs
to
specific
tissue
areas,
promoting
cell
integration
regeneration.
Effective
microcapsules
must
not
only
be
permeable
for
micronutrient
diffusion
but
mechanically
stable.
Alginate
hydrogel
is
one
commonly
used
biomaterials
fabricating
due
its
gel-forming
ability
low
toxicity.
However,
mechanical
instability,
inertness,
excessive
porosity
have
impeded
use.
Embedding
nanofibrils
in
alginate
improves
their
biological
properties.
In
this
research,
electrospun
composite
nanofibers
PCL–gelatin
(PG)
were
first
fabricated,
characterized,
cryoground.
The
filtered
cryoground
powder
solution
was
mixed
with
through
electrospray,
fabricated
into
microcapsules.
Parameters
such
as
flow
rate,
voltage,
composition,
which
are
critical
electrostatic
encapsulation
process,
optimized.
further
immersed
different
solvent
environments
(DI
water,
complete
media,
PBS),
observed
compared
morphology,
size
distribution,
stability
average
diameters
PG
ranged
between
0.2
2
μm,
an
58
73%.
varied
300
900
depending
on
environment.
Overall,
results
showed
improved
3D
network
suitable
biomedical
applications.
Язык: Английский
New Generation of Osteoinductive and Antimicrobial Polycaprolactone-Based Scaffolds in Bone Tissue Engineering: A Review
Polymers,
Год журнала:
2024,
Номер
16(12), С. 1668 - 1668
Опубликована: Июнь 12, 2024
With
respect
to
other
fields,
bone
tissue
engineering
has
significantly
expanded
in
recent
years,
leading
not
only
relevant
advances
biomedical
applications
but
also
innovative
perspectives.
Polycaprolactone
(PCL),
produced
the
beginning
of
1930s,
is
a
biocompatible
and
biodegradable
polymer.
Due
its
mechanical
physicochemical
features,
as
well
being
easily
shapeable,
PCL-based
constructs
can
be
with
different
shapes
degradation
kinetics.
Moreover,
due
various
development
processes,
PCL
made
3D
scaffolds
or
fibres
for
regeneration
applications.
This
outstanding
biopolymer
versatile
because
it
modified
by
adding
agents
antimicrobial
properties,
antibiotics/antifungals,
metal
ions
natural
compounds.
In
addition,
ameliorate
osteoproliferative
blended
calcium
phosphates.
review
an
overview
current
state
our
investigation
into
modifications
designed
impair
microbial
adhesive
capability
and,
parallel,
allow
eukaryotic
cell
viability
integration,
comparison
previous
reviews
excellent
research
papers.
Our
results
demonstrated
that
developed
had
high
interconnected
porosity,
addition
biphasic
phosphate
improved
human
attachment
proliferation.
The
incorporation
alternative
antimicrobials-for
instance,
silver
essential
oils-at
tuneable
concentrations
counteracted
growth
biofilm
formation,
without
affecting
cells'
viability.
Notably,
this
challenging
area
needs
multidisciplinary
work
material
scientists,
biologists,
orthopaedic
surgeons
determine
most
suitable
on
biomaterials
design
favourable
based
targeted
healing
damaged
tissue.
Язык: Английский