Nanoscale, Год журнала: 2024, Номер unknown
Опубликована: Дек. 26, 2024
Neurodegenerative diseases, characterized by the progressive deterioration of neuronal function and structure, pose significant global public health economic challenges.
Язык: Английский
Deleted Journal, Год журнала: 2025, Номер unknown
Опубликована: Фев. 24, 2025
Язык: Английский
Процитировано
15
Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 106622 - 106622
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
4
International Journal of Scientific Research in Science and Technology, Год журнала: 2025, Номер 12(1), С. 161 - 173
Опубликована: Янв. 26, 2025
Iron oxide nanoparticles (IONPs) have emerged as a transformative tool in oncology, offering unprecedented opportunities for early cancer diagnosis and effective treatment. These exhibit unique physicochemical properties, including superparamagnetism, biocompatibility, large surface area-to-volume ratio. properties make them particularly suitable applications such high-resolution imaging, targeted drug delivery, hyperthermia therapy. Additionally, their ability to be functionalized with various biomolecules enables precision targeting of cancerous tissues, further enhancing efficacy. This article delves into the cutting-edge advancements utilization IONPs, examines multifunctional roles addresses challenges clinical translation, outlines future directions research application this dynamic field.
Язык: Английский
Процитировано
0
Solid State Sciences, Год журнала: 2025, Номер unknown, С. 107880 - 107880
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
ACS Sensors, Год журнала: 2025, Номер unknown
Опубликована: Апрель 11, 2025
Prostate cancer (PCa), the second most common in men, demands effective early detection strategies. Elevated spermine levels prostate tissue contrast with decreased urinary concentrations PCa patients. Here, we present a novel sensing platform combining differential pulse voltammetry and an extended gate field-effect transistor (EGFET) molecularly imprinted polymer|molecular imprinting (MIP) nanofilm for selective sensitive detection. Key advancements include successfully constructing characterizing pseudoreference electrode precisely engineered analyte binding interface. The Ag/AgCl exhibited high reliability reproducibility, optimized to enhance conductivity minimize interference noises. Electrochemical analysis confirmed successful MIP modification, creating precise 3D-imprinted accurately quantified artificial urine across from 0.1 1000 ng/mL, achieving limit of 1.23 ng/mL. High selectivity was demonstrated against competing polyamines such as spermidine histamine. Analysis electrical properties indicated that induced changes surface potential, altering metal-oxide-semiconductor threshold voltage validating system's sensitivity. superior performance factor (IF ≈ 4.1) sensitivity 10 times higher compared nonimprinted polymers. Hill-Langmuir strong affinity spermine. Clinical validation using human samples diagnostic evaluations consistency liquid chromatography mass spectrometry, exhibiting excellent linear correlation (R2 = 0.97) without statistically significant differences (p-value <0.0001). This study introduces robust, miniaturized, cost-effective EGFET-based sensor detection, offering substantial potential clinical diagnostics biomarker monitoring.
Язык: Английский
Процитировано
0
Nanomaterials, Год журнала: 2025, Номер 15(9), С. 637 - 637
Опубликована: Апрель 22, 2025
This study presents the preparation of hybrid iron oxide nanocomposites through a two-step process combining microfluidic-assisted synthesis and post-synthetic surface modification. Fe3O4 nanoparticles were synthesized simultaneously functionalized with salicylic acid using three-dimensional vortex-type microfluidic chip, enabling rapid uniform particle formation. The resulting Fe3O4/SA nanostructures further modified either silver or copper to form enhanced antimicrobial functionality. These subsequently integrated into silica aerogel matrices dip-coating approach improve dispersion, structural stability, biocompatibility. morphological properties samples investigated XRD, FT-IR, TEM SAED analysis, Raman microscopy. In vitro cytotoxicity assays demonstrated that Fe3O4/SA–Ag Fe3O4/SA–CuO exhibit potent antibacterial activity cell type-dependent vivo biodistribution studies showed no accumulation in major organs selective clearance via spleen, validating systemic safety platform. findings highlight potential as biocompatible, coatings for advanced biomedical surfaces.
Язык: Английский
Процитировано
0
ACS Applied Bio Materials, Год журнала: 2025, Номер unknown
Опубликована: Май 12, 2025
RNA interference (RNAi) has emerged as a transformative approach for cancer therapy, enabling precise gene silencing through small interfering (siRNA). However, the clinical application of siRNA-based treatments faces challenges such rapid degradation, inefficient cellular uptake, and immune system clearance. Nanotechnology-enhanced siRNA delivery revolutionized therapy by addressing these limitations, improving stability, tumor-specific targeting, therapeutic efficacy. Recent advancements in nanocarrier engineering have introduced innovative strategies to enhance safety precision therapies, offering new opportunities personalized medicine. This review highlights three key innovations nanotechnology-enhanced delivery: artificial intelligence (AI)-driven design, multifunctional nanoparticles combined strategies, biomimetic nanocarriers enhanced biocompatibility. AI-driven utilize machine learning algorithms optimize nanoparticle properties, drug release profiles minimizing off-target effects. Multifunctional integrate with chemotherapy, immunotherapy, or photothermal synergistic treatment approaches that outcomes reduce resistance. Biomimetic nanocarriers, including exosome-mimicking systems cell-membrane-coated nanoparticles, improve circulation time, evasion, targeted tumor delivery. These collectively precision, efficiency, therapies. The scope novelty lie their ability overcome primary barriers while paving way clinically viable solutions. provides comprehensive analysis latest developments fabrication, preclinical studies, assessments. By integrating multifunctionality, biomimicry, holds immense potential future therapy.
Язык: Английский
Процитировано
0
Nanoscale, Год журнала: 2024, Номер unknown
Опубликована: Дек. 26, 2024
Neurodegenerative diseases, characterized by the progressive deterioration of neuronal function and structure, pose significant global public health economic challenges.
Язык: Английский
Процитировано
1