A Comprehensive Review of the Diversity of Fungal Secondary Metabolites and Their Emerging Applications in Healthcare and Environment
Mycobiology,
Год журнала:
2024,
Номер
52(6), С. 335 - 387
Опубликована: Ноя. 1, 2024
Fungi
and
their
natural
products,
like
secondary
metabolites,
have
gained
a
huge
demand
in
the
last
decade
due
to
increasing
applications
healthcare,
environmental
cleanup,
biotechnology-based
industries.
The
fungi
produce
these
metabolites
(SMs)
during
different
phases
of
growth,
which
are
categorized
into
terpenoids,
alkaloids,
polyketides,
non-ribosomal
peptides.
These
SMs
exhibit
significant
biological
activity,
contributes
formulation
novel
pharmaceuticals,
biopesticides,
bioremediation
agents.
Nowadays,
fungal-derived
widely
used
food
beverages,
for
fermentation,
preservatives,
protein
sources,
dairy
In
it
is
being
as
an
antimicrobial,
anticancer,
anti-inflammatory,
immunosuppressive
drug.
usage
modern
tools
biotechnology
can
achieve
increase
large-scale
production.
present
review
comprehensively
analyses
diversity
fungal
along
with
emerging
agriculture,
sustainability,
nutraceuticals.
Here,
authors
reviewed
recent
advancements
genetic
engineering,
metabolic
pathway
manipulation,
synthetic
biology
improve
production
yield
SMs.
Advancement
fermentation
techniques,
bioprocessing,
co-cultivation
approaches
Investigators
further
highlighted
importance
omics
technologies
understanding
regulation
biosynthesis
SMs,
offers
drug
discovery
sustainable
agriculture.
Finally,
addressed
potential
manipulation
biotechnological
innovations
exploitation
commercial
benefits.
Язык: Английский
The Aspergillus nidulans velvet domain containing transcription factor VeA is shuttled from cytoplasm into nucleus during vegetative growth and stays there for sexual development, but has to return into cytoplasm for asexual development
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 29, 2025
Abstract
Survival
of
multicellular
organisms
requires
the
coordinated
interplay
between
networks
regulating
gene
expression
and
controlled
intracellular
transport
respective
regulators.
Velvet
domain
proteins
are
fungal
transcription
factors,
which
form
various
heterodimers
play
key
roles
in
controlling
early
developmental
decisions
towards
more
either
asexual
or
sexual
differentiation.
VeA
is
central
subunit
trimeric
velvet
complex
VelB-VeA-LaeA,
links
transcriptional
to
epigenetic
control
for
coordination
programs
specific
secondary
metabolite
synthesis.
Nuclear
localization
bridging
factor
carefully
fungi.
carries
three
nuclear
signals
NLS1,
NLS2
NLS3,
all
contribute
import.
An
additional
export
sequence
(NES)
provides
a
shuttle
function,
allows
cell
relocate
cytoplasm.
during
vegetative
growth,
but
has
be
exported
from
nucleus
allow
promote
development.
In
contrast,
progression
pathway
continuous
localization.
Accurate
import
further
connected
stability
mechanism
as
prerequisites
development
metabolism.
These
results
illustrate
mutual
dependencies
regulatory
coordinating
Язык: Английский
laeA Gene Introduction Strategy Enabling the Construction of a Prolific Fungal Secondary Metabolite Library
Journal of Natural Products,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 20, 2025
LaeA
is
a
putative
nuclear
methyltransferase
protein
that
epigenetically
influences
secondary
metabolite
production
in
fungi.
has
drawn
attention
as
one
of
the
promising
approaches
to
activate
fungal
chemical
production,
and
laeA
gene
been
introduced
into
some
strains
with
aim
producing
metabolic
changes
mainly
based
on
evaluation
mycotoxicity.
However,
these
studies
were
applied
for
limited
species,
its
utility
versatility
broad
species
remained
unclear.
In
this
study,
47
selected
composed
three
different
genera,
Pochonia
spp.,
Gamszarea
kalimantanensis,
Lecanicillium
which
have
never
modified
gene.
We
obtained
total
125
mutants
genes
our
strain
library.
The
productivity
biological
activity
library
analyzed,
two
natural
products,
radicicol
(1)
sch210972
(2),
isolated
more
than
10-fold
yield
parent
strains.
Язык: Английский
Effect of low intensity-magnetic field coupled with blue light on β-carotene synthesis in Blakeslea trispora
Food and Bioproducts Processing,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
Язык: Английский
Separation of life stages within anaerobic fungi (Neocallimastigomycota) highlights differences in global transcription and metabolism
Fungal Genetics and Biology,
Год журнала:
2024,
Номер
unknown, С. 103958 - 103958
Опубликована: Дек. 1, 2024
Язык: Английский
Recent Updates on the Secondary Metabolites from Fusarium Fungi and Their Biological Activities (Covering 2019 to 2024)
Prosper Amuzu,
Xiaoqian Pan,
Xuwen Hou
и другие.
Journal of Fungi,
Год журнала:
2024,
Номер
10(11), С. 778 - 778
Опубликована: Ноя. 9, 2024
Fusarium
species
are
commonly
found
in
soil,
water,
plants,
and
animals.
A
variety
of
secondary
metabolites
with
multiple
biological
activities
have
been
recently
isolated
from
species,
making
fungi
a
treasure
trove
bioactive
compounds.
This
mini-review
comprehensively
highlights
the
newly
produced
by
their
various
reported
2019
to
October
2024.
About
276
novel
were
revealed
at
least
21
this
period.
The
main
nitrogen-containing
compounds,
polyketides,
terpenoids,
steroids,
phenolics.
mostly
belonged
plant
endophytic,
pathogenic,
soil-derived,
marine-derived
fungi.
mainly
displayed
antibacterial,
antifungal,
phytotoxic,
antimalarial,
anti-inflammatory,
cytotoxic
activities,
suggesting
medicinal
agricultural
applications.
aims
increase
diversity
order
accelerate
development
Язык: Английский