A Comprehensive Review of the Diversity of Fungal Secondary Metabolites and Their Emerging Applications in Healthcare and Environment

Mycobiology, Journal Year: 2024, Volume and Issue: 52(6), P. 335 - 387

Published: Nov. 1, 2024

Fungi and their natural products, like secondary metabolites, have gained a huge demand in the last decade due to increasing applications healthcare, environmental cleanup, biotechnology-based industries. The fungi produce these metabolites (SMs) during different phases of growth, which are categorized into terpenoids, alkaloids, polyketides, non-ribosomal peptides. These SMs exhibit significant biological activity, contributes formulation novel pharmaceuticals, biopesticides, bioremediation agents. Nowadays, fungal-derived widely used food beverages, for fermentation, preservatives, protein sources, dairy In it is being as an antimicrobial, anticancer, anti-inflammatory, immunosuppressive drug. usage modern tools biotechnology can achieve increase large-scale production. present review comprehensively analyses diversity fungal along with emerging agriculture, sustainability, nutraceuticals. Here, authors reviewed recent advancements genetic engineering, metabolic pathway manipulation, synthetic biology improve production yield SMs. Advancement fermentation techniques, bioprocessing, co-cultivation approaches Investigators further highlighted importance omics technologies understanding regulation biosynthesis SMs, offers drug discovery sustainable agriculture. Finally, addressed potential manipulation biotechnological innovations exploitation commercial benefits.

Language: Английский

---

The Aspergillus nidulans velvet domain containing transcription factor VeA is shuttled from cytoplasm into nucleus during vegetative growth and stays there for sexual development, but has to return into cytoplasm for asexual development

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Abstract Survival of multicellular organisms requires the coordinated interplay between networks regulating gene expression and controlled intracellular transport respective regulators. Velvet domain proteins are fungal transcription factors, which form various heterodimers play key roles in controlling early developmental decisions towards more either asexual or sexual differentiation. VeA is central subunit trimeric velvet complex VelB-VeA-LaeA, links transcriptional to epigenetic control for coordination programs specific secondary metabolite synthesis. Nuclear localization bridging factor carefully fungi. carries three nuclear signals NLS1, NLS2 NLS3, all contribute import. An additional export sequence (NES) provides a shuttle function, allows cell relocate cytoplasm. during vegetative growth, but has be exported from nucleus allow promote development. In contrast, progression pathway continuous localization. Accurate import further connected stability mechanism as prerequisites development metabolism. These results illustrate mutual dependencies regulatory coordinating

Language: Английский

---

laeA Gene Introduction Strategy Enabling the Construction of a Prolific Fungal Secondary Metabolite Library

Journal of Natural Products, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 20, 2025

LaeA is a putative nuclear methyltransferase protein that epigenetically influences secondary metabolite production in fungi. has drawn attention as one of the promising approaches to activate fungal chemical production, and laeA gene been introduced into some strains with aim producing metabolic changes mainly based on evaluation mycotoxicity. However, these studies were applied for limited species, its utility versatility broad species remained unclear. In this study, 47 selected composed three different genera, Pochonia spp., Gamszarea kalimantanensis, Lecanicillium which have never modified gene. We obtained total 125 mutants genes our strain library. The productivity biological activity library analyzed, two natural products, radicicol (1) sch210972 (2), isolated more than 10-fold yield parent strains.

Language: Английский

---

Effect of low intensity-magnetic field coupled with blue light on β-carotene synthesis in Blakeslea trispora

Food and Bioproducts Processing, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

---

Separation of life stages within anaerobic fungi (Neocallimastigomycota) highlights differences in global transcription and metabolism

Fungal Genetics and Biology, Journal Year: 2024, Volume and Issue: unknown, P. 103958 - 103958

Published: Dec. 1, 2024

Language: Английский

---

Recent Updates on the Secondary Metabolites from Fusarium Fungi and Their Biological Activities (Covering 2019 to 2024)

Journal of Fungi, Journal Year: 2024, Volume and Issue: 10(11), P. 778 - 778

Published: Nov. 9, 2024

Fusarium species are commonly found in soil, water, plants, and animals. A variety of secondary metabolites with multiple biological activities have been recently isolated from species, making fungi a treasure trove bioactive compounds. This mini-review comprehensively highlights the newly produced by their various reported 2019 to October 2024. About 276 novel were revealed at least 21 this period. The main nitrogen-containing compounds, polyketides, terpenoids, steroids, phenolics. mostly belonged plant endophytic, pathogenic, soil-derived, marine-derived fungi. mainly displayed antibacterial, antifungal, phytotoxic, antimalarial, anti-inflammatory, cytotoxic activities, suggesting medicinal agricultural applications. aims increase diversity order accelerate development

Language: Английский

---