Food Science & Nutrition,
Год журнала:
2025,
Номер
13(4)
Опубликована: Апрель 1, 2025
ABSTRACT
Carcinogenesis
is
the
process
by
which
substances
that
cause
cancer
(carcinogens)
produce
cancer.
Extensive
research
conducted
in
recent
years
shows
risk
of
developing
certain
cancers
can
be
reduced
eating
a
variety
fruits
and
vegetables
regularly.
Catechins,
are
more
prevalent
foods
beverages
made
from
plants,
known
to
have
anti‐cancer
effects.
Detailed
mechanistic
studies
helpful
understanding
inhibitory
effects
catechins
on
carcinogenesis
providing
background
information
for
evaluating
human
carcinogenesis.
This
article
provides
an
overview
their
potential
roles
prevention
treatment,
focusing
how
they
alter
signaling
pathways,
slow
cell
proliferation,
trigger
apoptosis.
Also,
this
discusses
molecular
modifications
epigallocatechin
gallate
as
well
delivery
methods
based
nanostructures.
Frontiers in Chemistry,
Год журнала:
2023,
Номер
11
Опубликована: Май 10, 2023
Introduction:
Free
radicals
are
reactive
oxygen
species
that
constantly
circulate
through
the
body
and
occur
as
a
side
effect
of
many
reactions
take
place
in
human
body.
Under
normal
conditions,
they
removed
from
by
antioxidant
processes.
If
these
natural
mechanisms
disrupted,
accumulate
excess
contribute
to
development
diseases.
Methodology:
Relevant
recent
information
on
oxidative
stress,
free
radicals,
species,
synthetic
antioxidants
was
collected
researching
electronic
databases
such
PubMed
/
Medline,
Web
Science,
Science
Direct.
Results:
According
analysed
studies,
this
comprehensive
review
provided
update
their
impact
pathophysiology
Discussion:
To
counteract
condition
must
be
external
sources
supplement
defense
mechanism
internally.
Because
therapeutic
potential
origin,
medicinal
plants
have
been
reported
main
source
phytocompounds.
Some
non-enzymatic
phytocompounds
flavonoids,
polyphenols,
glutathione,
along
with
some
vitamins
possess
strong
activities
vivo
vitro
studies.
Thus,
present
describes,
brief,
overview
stress-directed
cellular
damage
unction
dietary
management
different
The
limitations
correlating
activity
foods
health
were
also
discussed.
Gallic
acid
(GA)
is
a
phenolic
molecule
found
naturally
in
wide
range
of
fruits
as
well
medicinal
plants.
It
has
many
health
benefits
due
to
its
antioxidant
properties.
This
study
focused
on
finding
out
the
neurobiological
effects
and
mechanisms
GA
using
published
data
from
reputed
databases.
For
this,
were
collected
various
sources,
such
PubMed/Medline,
Science
Direct,
Scopus,
Google
Scholar,
SpringerLink,
Web
Science.
The
findings
suggest
that
can
be
used
manage
several
neurological
diseases
disorders,
Alzheimer's
disease,
Parkinson's
strokes,
sedation,
depression,
psychosis,
neuropathic
pain,
anxiety,
memory
loss,
neuroinflammation.
According
database
reports
this
current
literature-based
study,
may
considered
one
potential
lead
compounds
treat
disorders.
More
preclinical
clinical
studies
are
required
establish
neuroprotective
drug.
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
162, С. 114687 - 114687
Опубликована: Апрель 14, 2023
Cancer
is
still
the
leading
cause
of
death
worldwide,
burdening
global
medical
system.
Rosmarinic
acid
(RA)
among
first
secondary
metabolites
discovered
and
it
a
bioactive
compound
identified
in
plants
such
as
Boraginaceae
Nepetoideae
subfamilies
Lamiaceae
family,
including
Thymus
masticmasti
chinaythia
koreana,
Ocimum
sanctum,
Hyptis
pectinate.
This
updated
review
to
highlight
chemopreventive
chemotherapeutic
effects
RA
its
derivatives,
thus
providing
valuable
clues
for
potential
development
some
complementary
drugs
treatment
cancers.
Relevant
information
about
RA's
derivatives
were
collected
from
electronic
scientific
databases,
PubMed/Medline,
Scopus,
TRIP
database,
Web
Science,
Science
Direct.
The
results
studies
showed
numerous
significant
biological
antiviral,
antibacterial,
anti-inflammatory,
anti-tumour,
antioxidant
antiangiogenic
effects.
Most
on
anticancer
with
corresponding
mechanisms
are
experimental
preclinical
stage
missing
evidence
clinical
trials
support
research.
To
open
new
therapeutic
perspectives
future
must
elucidate
molecular
targets
action
more
detail,
human
toxic
adverse
Phytotherapy Research,
Год журнала:
2024,
Номер
38(6), С. 3169 - 3189
Опубликована: Апрель 14, 2024
Abstract
Alzheimer's
disease
(AD)
is
a
progressive
neurodegenerative
disorder
characterized
by
the
accumulation
of
amyloid‐beta
plaques
and
neurofibrillary
tangles,
leading
to
neuronal
loss.
Curcumin,
polyphenolic
compound
derived
from
Curcuma
longa
,
has
shown
potential
neuroprotective
effects
due
its
anti‐inflammatory
antioxidant
properties.
This
review
aims
synthesize
current
preclinical
data
on
anti‐neuroinflammatory
mechanisms
curcumin
in
context
AD,
addressing
pharmacokinetics,
bioavailability,
as
therapeutic
adjunct.
An
exhaustive
literature
search
was
conducted,
focusing
recent
studies
within
last
10
years
related
curcumin's
impact
neuroinflammation
role
AD.
The
methodology
included
sourcing
articles
specialized
databases
using
specific
medical
subject
headings
terms
ensure
precision
relevance.
Curcumin
demonstrates
significant
properties
modulating
neuroinflammatory
pathways,
scavenging
reactive
oxygen
species,
inhibiting
production
pro‐inflammatory
cytokines.
Despite
potential,
challenges
remain
regarding
limited
bioavailability
scarcity
comprehensive
human
clinical
trials.
emerges
promising
adjunct
AD
multimodal
benefits.
However,
further
research
required
overcome
establish
effective
dosing
regimens
subjects.
Developing
novel
delivery
systems
formulations
may
enhance
treatment.
Arabian Journal of Chemistry,
Год журнала:
2023,
Номер
16(5), С. 104680 - 104680
Опубликована: Фев. 15, 2023
The
Camellia
sinensis
plant
provides
a
wide
diversity
of
black,
green,
oolong,
yellow,
brick
dark,
and
white
tea.
Tea
is
one
the
majorly
used
beverages
across
globe,
succeeds
only
in
water
for
fitness
pleasure.
Generally,
green
tea
has
been
preferred
more
as
compared
to
other
teas
due
its
main
constituent
e.g.
polyphenols
which
contribute
various
health
benefits.
aim
this
updated
comprehensive
review
bring
together
latest
data
on
phytochemistry
pharmacological
properties
highlight
therapeutic
prospects
bioactive
compounds
so
that
full
medicinal
potential
can
be
realised.
A
published
studies
topic
was
performed
by
searching
PubMed/MedLine,
Scopus,
Google
scholar,
Web
Science
databases
from
1999
2022.
results
analysed
showed
are
four
prime
flavonoids
catechins:
epigallocatechin
gallate
(EGCG),
epicatechin
(ECG),
(EGC),
(EC)
along
with
beneficial
biological
broad
heterogeneity
disorders,
including
anticancer,
neuroprotective,
antibacterial,
antiviral,
antifungal,
antiobesity,
antidiabetes
antiglaucoma
activities.
Poor
absorption
low
bioavailability
limiting
aspects
their
use.
More
human
clinical
approaching
nanoformulation
techniques
nanoparticles
transport
target
phytochemical
increase
efficacy
needed
future.
ACS Applied Bio Materials,
Год журнала:
2024,
Номер
7(6), С. 3535 - 3555
Опубликована: Май 20, 2024
Alzheimer's
disease
(AD)
is
a
neurological
condition
currently
with
47
million
people
suffering
from
it
globally.
AD
might
have
many
reasons
such
as
genetic
issues,
environmental
factors,
and
Aβ
accumulation,
which
the
biomarker
of
disease.
Since
primary
reason
unknown,
there
no
targeted
treatment
at
moment,
but
ongoing
research
aims
to
slow
its
progression
by
managing
amyloid-beta
peptide
production
rather
than
symptomatic
improvement.
phytochemicals
been
demonstrated
possess
antioxidant,
anti-inflammatory,
neuroprotective
properties,
they
may
target
multiple
pathological
factors
can
reduce
risk
Curcumin,
phytochemical
found
in
turmeric
known
for
free
radical
scavenging
an
antiamyloid
treating
AD,
has
come
under
investigation.
Although
low
bioavailability
limits
efficacy,
prominent
drug
delivery
system
(DDS)
desired
overcome
it.
Hence,
potency
lipid-based
nanoparticles
encapsulating
curcumin
(LNPs-CUR)
considered
this
study
promising
DDS.
In
vivo
studies
animal
models
indicate
LNPs-CUR
effectively
amyloid
plaque
formation,
leading
cognitive
enhancement
reduced
toxicity
compared
CUR.
However,
deeper
understanding
CUR's
pharmacokinetics
safety
profile
crucial
before
be
medicine.
Future
investigations
explore
combination
NPs
other
therapeutic
agents
increase
their
efficacy
cases.
This
review
provides
current
position
CUR
therapy
paradigm,
DDS
suggestions
CUR,
previous
point
analytical
view
focused
on
advantages
challenges.
Phytotherapy Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 15, 2025
Alzheimer's
disease
(AD)
is
a
type
of
neurodegenerative
illness
in
which
β-amyloid
(Aβ)
and
tau
protein
accumulate
neurons
the
form
tangles.
The
pathophysiological
pathway
AD
consists
Aβ-amyloid
peptides,
proteins,
oxidative
stress
increased
neuro-inflammatory
response.
Food
Drug
Administration
United
States
has
authorized
various
drugs
for
effective
treatment
AD,
include
galantamine,
rivastigmine,
donepezil,
memantine,
sodium
oligomannate,
lecanemab,
aducanumab.
major
disadvantage
these
that
they
only
provide
"symptomatic"
relief.
They
are
most
early
stages
or
mild
to
moderate
cases
disease,
but
not
suitable
long-term
use.
Besides
conventional
therapies,
phytochemicals
have
potential
stop
progression
AD.
According
research,
use
against
gained
attention
due
their
potent
anti-inflammatory,
antioxidant,
anti-hyperphosphorylation
protein,
metal
chelation,
anti-amyloid
properties.
This
study
seeks
an
up-to-date
compilation
current
promising
breakthroughs
therapy
using
phytochemicals.
It
could
be
concluded
light
serve
as
However,
more
mechanistic
investigations
needed
determine
clinical
implications
treatment.
