Neuropsychopharmacology, Год журнала: 1998, Номер 19(5), С. 354 - 364
Опубликована: Ноя. 1, 1998
Язык: Английский
Ageing Research Reviews, Год журнала: 2023, Номер 89, С. 101994 - 101994
Опубликована: Июнь 28, 2023
Язык: Английский
Процитировано
69
Cells, Год журнала: 2022, Номер 11(15), С. 2432 - 2432
Опубликована: Авг. 5, 2022
Peroxisome proliferator-activated receptors (PPARs) function as nuclear transcription factors upon the binding of physiological or pharmacological ligands and heterodimerization with retinoic X receptors. Physiological include fatty acids fatty-acid-derived compounds low specificity for different PPAR subtypes (alpha, beta/delta, gamma). For each subtypes, specific agonists antagonists, well pan-agonists, are available. In agreement their natural ligands, PPARs mainly focused on targets treatment metabolic syndrome its associated complications. Nevertheless, many publications available that implicate in malignancies. several instances, they controversial very similar models. Thus, to better predict potential use modulators personalized medicine therapies against malignancies, it seems necessary timely review three relation didactic concept cancer hallmark capabilities. We previously described functions beta/delta respect hallmarks reviewed implications all angiogenesis. current updates our knowledge beta extends alpha gamma.
Язык: Английский
Процитировано
45
Pharmacology & Therapeutics, Год журнала: 2022, Номер 240, С. 108293 - 108293
Опубликована: Окт. 8, 2022
Язык: Английский
Процитировано
43
Pharmaceutics, Год журнала: 2022, Номер 14(3), С. 656 - 656
Опубликована: Март 16, 2022
In the current research, a thymoquinone-enriched naringenin (NGN)-loaded nanostructured lipid carrier (NLC) was developed and delivered via nasal route for depression. Thymoquinone (TQ) oil used as liquid provided synergistic effects. A TQ- NGN-enriched NLC ultrasonication technique optimized using central composite rotatable design (CCRD). The exhibited following properties: droplet size, 84.17 to 86.71 nm; PDI, 0.258 0.271; zeta potential, -8.15 -8.21 mV; % EE, 87.58 88.21%. in vitro drug release profile showed supremacy of TQ-NGN-NLC comparison NGN suspension, with cumulative 82.42 ± 1.88% from 38.20 0.82% suspension. Ex vivo permeation study displayed 2.21-fold increase compared DPPH better antioxidant potential alone due effect TQ oil. CLSM images revealed deeper NGN-NLC (39.9 µm) through mucosa suspension (20 µm). Pharmacodynamic studies, such forced swim test locomotor activity test, were assessed depressed rat model, which remarkable antidepressant marketed formulation. results signify TQ-enriched enhancing brain delivery therapeutic depression treatment.
Язык: Английский
Процитировано
38
Ageing Research Reviews, Год журнала: 2023, Номер 85, С. 101838 - 101838
Опубликована: Янв. 5, 2023
Язык: Английский
Процитировано
24
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(8), С. 6888 - 6888
Опубликована: Апрель 7, 2023
Major depressive disorder is one of the most common mental illnesses that highly impairs quality life. Pharmacological interventions are mainly focused on altered monoamine neurotransmission, which considered primary event underlying disease's etiology. However, many other neuropathological mechanisms contribute to progression and clinical symptoms have been identified. These include oxidative stress, neuroinflammation, hippocampal atrophy, reduced synaptic plasticity neurogenesis, depletion neurotrophic factors, dysfunction hypothalamic-pituitary-adrenal (HPA) axis. Current therapeutic options often unsatisfactory associated with adverse effects. This review highlights relevant findings concerning role flavonols, a ubiquitous class flavonoids in human diet, as potential antidepressant agents. In general, flavonols be both an effective safe option management depression, largely based their prominent antioxidative anti-inflammatory Moreover, preclinical studies provided evidence they capable restoring neuroendocrine control HPA axis, promoting alleviating depressive-like behavior. Although these promising, still far from being implemented practice. Hence, further needed more comprehensively evaluate respect improvement signs depression.
Язык: Английский
Процитировано
19
Frontiers in Pharmacology, Год журнала: 2023, Номер 14
Опубликована: Март 29, 2023
Major depressive disorder (MDD) is a psychiatric with increasing prevalence worldwide. It leading cause of disability and suicide, severely affecting physical mental health. However, the study depression remains at an exploratory stage in terms diagnostics treatment due to complexity its pathogenesis. MicroRNAs are endogenous short-stranded non-coding RNAs capable binding 3’untranslated region mRNAs. Because their ability repress translation process genes found high levels brain tissues, investigation role has gradually increased recently. This article summarizes recent research progress on relationship between microRNAs depression. The play regulatory pathophysiology depression, involving dysregulation monoamines, abnormalities neuroplasticity neurogenesis, hyperactivity HPA axis, inflammatory responses. These might provide new clue for diagnosis MDD, development antidepressant drugs.
Язык: Английский
Процитировано
18
Journal of Ethnopharmacology, Год журнала: 2023, Номер 308, С. 116254 - 116254
Опубликована: Фев. 11, 2023
Язык: Английский
Процитировано
15
Journal of Cellular and Molecular Medicine, Год журнала: 2023, Номер 28(5)
Опубликована: Сен. 12, 2023
Abstract Peroxisome proliferator‐activated receptors (PPARs) are transcription factors belonging to the nuclear receptor family. There three subtypes of PPARs, including PPAR‐α, PPAR‐β/δ and PPAR‐γ. They expressed in different tissues act by regulating expression target genes form binding ligands. Various PPAR have been shown significant roles a wide range biological processes lipid metabolism, body energy homeostasis, cell proliferation differentiation, bone formation, tissue repair remodelling. Recent studies found that PPARs closely related tumours. involved cancer growth, angiogenesis tumour immune response, essential components progression metastasis. As such, they become for therapy research. In this review, we discussed current state knowledge on involvement cancer, their role tumourigenesis, impact microenvironment potential using combinational treat targeting signal pathways, or as adjuvants boost effects chemo immunotherapies. Our review highlights complexity need better understanding mechanism order design effective therapies.
Язык: Английский
Процитировано
15
Pharmaceuticals, Год журнала: 2023, Номер 16(11), С. 1535 - 1535
Опубликована: Окт. 30, 2023
N-methyl-D-aspartate receptors (NMDARs) are ion channels that respond to the neurotransmitter glutamate, playing a crucial role in permeability of calcium ions and excitatory neurotransmission central nervous system (CNS). Composed various subunits, NMDARs predominantly formed by two obligatory GluN1 subunits (with eight splice variants) along with regulatory GluN2 (GluN2A-2D) GluN3 (GluN3A-B). They widely distributed throughout CNS involved essential functions such as synaptic transmission, learning, memory, plasticity, excitotoxicity. The presence GluN2A GluN2B is particularly important for cognitive processes has been strongly implicated neurodegenerative diseases like Parkinson’s disease Alzheimer’s disease. Understanding roles neuropathologies provides valuable insights into underlying causes complexities major disorders. This knowledge vital development selective antagonists targeting using pharmacological molecular methods. Such represent promising class NMDA receptor inhibitors have potential be developed neuroprotective drugs optimal therapeutic profiles.
Язык: Английский
Процитировано
14