Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Фев. 16, 2024

Abstract The human gastrointestinal tract is populated with a diverse microbial community. vast genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every aspect biology, including health maintenance, development, aging, disease. advent new sequencing technologies culture-independent methods has allowed researchers to move beyond correlative studies toward mechanistic explorations shed light on microbiome–host interactions. Evidence unveiled bidirectional communication between central nervous system, referred as “microbiota–gut–brain axis”. microbiota–gut–brain axis represents an important regulator glial functions, making it actionable target ameliorate development progression neurodegenerative diseases. In this review, we discuss mechanisms As provides essential cues microglia, astrocytes, oligodendrocytes, examine communications microbiota these cells during healthy states Subsequently, diseases using metabolite-centric approach, while also examining role microbiota-related neurotransmitters hormones. Next, targeting intestinal barrier, blood–brain meninges, peripheral immune system counteract dysfunction neurodegeneration. Finally, conclude by assessing pre-clinical clinical evidence probiotics, prebiotics, fecal transplantation A thorough comprehension will foster effective therapeutic interventions for management

Язык: Английский

---

A Multimodal Meta-Analytical Evidence of Functional and Structural Brain Abnormalities Across Alzheimer's Disease Spectrum

Ageing Research Reviews, Год журнала: 2024, Номер 95, С. 102240 - 102240

Опубликована: Фев. 22, 2024

Язык: Английский

---

Opioid use and abuse in adolescents and young adults; dealing with science, laws and ethics: Charming the COBRAS

Disease-a-Month, Год журнала: 2025, Номер unknown, С. 101853 - 101853

Опубликована: Янв. 1, 2025

Язык: Английский

---

Tangeretin offers neuroprotection against colchicine-induced memory impairment in Wistar rats by modulating the antioxidant milieu, inflammatory mediators and oxidative stress in the brain tissue

BMC Complementary Medicine and Therapies, Год журнала: 2025, Номер 25(1)

Опубликована: Фев. 4, 2025

Язык: Английский

---

Heterogeneous brain abnormalities in subjective cognitive decline converge on a common network and their transcriptional signature

Alzheimer s & Dementia, Год журнала: 2025, Номер 21(3)

Опубликована: Март 1, 2025

Abstract INTRODUCTION Subjective cognitive decline (SCD) is increasingly recognized as closely related to future Alzheimer's disease (AD). Numerous neuroimaging findings in SCD are inconsistent. We tested whether the various localize a common brain network. METHODS Using novel coordinate network mapping approach, we delineated damage networks that were functionally connected reported findings. then decoded these using microscale transcriptomic and chemo‐architectures psychological processes. RESULTS enrolled 45 studies comprising 2453 patients 3017 healthy controls. The identified largely localized somatosensory (SMN) default mode (DMN). Both robust perturbations of analyzed parameters an independent validation dataset. Neurobiology correlation analyses some key biological pathways neurotransmitters linked networks. DISCUSSION Our reconcile heterogeneous abnormalities provide richer neurobiological underpinning, which has implications for understanding with SCD. Highlights on reconciled framework. SCD‐related functional involves changes DMN, while structural mainly primary sensory areas. genes predominantly enriched processes synaptic structure, calcium ion binding, cellular metabolism. An ALE meta‐analysis was conducted comparison.

Язык: Английский

---

Navigating the Maze of Alzheimer’s disease by exploring BACE1: Discovery, current scenario, and future prospects

Ageing Research Reviews, Год журнала: 2024, Номер 98, С. 102342 - 102342

Опубликована: Май 16, 2024

Язык: Английский

---

Advances of curcumin in nervous system diseases: the effect of regulating oxidative stress and clinical studies

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Ноя. 1, 2024

In recent years, researchers have highly observed that neurological disorders (NSDs) with the aging of population are a global health burden whose prevalence is increasing every year. Previous evidence suggested occurrence correlated predisposing factors such as inflammation, aging, and injury. Particularly, neuronal cells susceptible to oxidative stress, leading lesions caused by high oxygen-consuming properties. Oxidative stress (OS) state peroxidation, which occurs result disruption balance between oxidizing antioxidizing substances. The intermediates free radicals, hydrogen peroxide (H

Язык: Английский

---

An Updated Review on Electrochemical Nanobiosensors for Neurotransmitter Detection

Biosensors, Год журнала: 2023, Номер 13(9), С. 892 - 892

Опубликована: Сен. 19, 2023

Neurotransmitters are chemical compounds released by nerve cells, including neurons, astrocytes, and oligodendrocytes, that play an essential role in the transmission of signals living organisms, particularly central nervous system, they also perform roles realizing function maintaining state each organ body. The dysregulation neurotransmitters can cause neurological disorders. This highlights significance precise neurotransmitter monitoring to allow early diagnosis treatment. review provides a complete multidisciplinary examination electrochemical biosensors integrating nanomaterials nanotechnologies order achieve accurate detection neurotransmitters. We introduce extensively researched their respective functions biological beings. Subsequently, classified based on methodologies employed for direct detection, encompassing recently documented cell-based systems. These methods involve neuronal cells vitro, identification emitted stem vivo incorporation into has potential assist timely management study significant insights researchers clinicians regarding its implications numerous applications.

Язык: Английский

---

A systematic review of the neuropathology and memory decline induced by monosodium glutamate in the Alzheimer’s disease-like animal model

Frontiers in Pharmacology, Год журнала: 2023, Номер 14

Опубликована: Окт. 24, 2023

This systematic review analyzes monosodium glutamate (MSG) in the Alzheimer’s disease-like condition to enhance translational research. Our seeks understand how MSG affects brain and causes degenerative disorders. Due significant preclinical data linking toxicity disease lack of a comprehensive or meta-analysis, we initiated study on MSG’s potential link. We searched PubMed, ScienceDirect, ProQuest, DOAJ, Scopus for animal research English language papers without time constraints. used PRISMA-P framework PICO technique collect population, intervention exposure, comparison, result data. It was registered PROSPERO as CRD42022371502. affected mice’s exploratory behaviors short-term working memory. The brain, hippocampus, cerebellar tissue demonstrated neuronal injury-related histological histomorphometric changes. A total 70% MSG-treated mice had poor nesting behavior. treated also more hyperphosphorylated tau protein their cortical hippocampus neurons. Glutamate glutamine levels increased with MSG, dose-dependent mixed horizontal locomotor, grooming, anxiety responses reduced. treatment significantly decreased phospho-CREB levels, supporting idea that neurons were harmed, despite CREB mRNA expression. High doses drastically lower serum serotonin levels. In conclusion, showed AD-like pathology, atrophy, memory impairment. Further longer span deeper behavioral characterization is needed. Systematic registration : https://www.crd.york.ac.uk/prospero/ , identifier [CRD42022371502].

Язык: Английский

---

Interplay between diphenyl diselenide and copper: Impact on D. melanogaster survival, behavior, and biochemical parameters

Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology, Год журнала: 2024, Номер 281, С. 109899 - 109899

Опубликована: Март 20, 2024

Язык: Английский

---