Bioactive compounds and biological activity in edible insects: A review

Heliyon, Год журнала: 2024, Номер 10(2), С. e24045 - e24045

Опубликована: Янв. 1, 2024

New strategies to combat hunger are a current and urgent demand. The increase in population has generated high demand for products services that affect food production, cultivation areas, climate. Viable sustainable alternative sources have been sought meet quality requirements. In this context, edible insects good source of macro-nutrients, bioactive compounds confer biological properties improve their nutritional aspects benefit human health. This review aims present the benefits contributions from point view contribution macronutrients, compounds, as well consider some anti-nutritional reported insects. It was found possess most macronutrients necessary life rich commonly plants. These can vary significantly depending on developmental stage, diet, species However, they also contain phytochemicals which anti-nutrients predominate, adversely humans with allergenic reactions or reduced nutrient viability when consumed amounts prolonged periods. Hydrocyanide, oxalates, soluble oxalate, phytate studied anti-nutrients. doses at occur far below limits foods. addition, anti-nutrient levels decrease processing, such oven-drying defatting methods. there few studies, so more trials needed avoid generalizing. Therefore, be considered complete food.

Язык: Английский

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Nontargeted metabolomics and enzyme inhibitory and antioxidant activities for chemical and biological characterization of jujube (Ziziphus jujuba) extracts

Journal of Pharmaceutical and Biomedical Analysis, Год журнала: 2024, Номер 242, С. 116040 - 116040

Опубликована: Фев. 15, 2024

Язык: Английский

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Alchemilla pseudocartalinica Juz: Phytochemical Screening by UPLC-MS/MS, Molecular Docking, Anti-oxidant, Anti-diabetic, Anti-glaucoma, and Anti-Alzheimer Effects

Records of Natural Products, Год журнала: 2024, Номер 2, С. 251 - 272

Опубликована: Март 9, 2024

Alchemilla species (Rosaceae) are popularly known as 'Lady's Mantle, Lion's claw' and used for medicinal purposes diuretic, laxative, tonic, wound healing agents.Bioactivities phenolic content of pseudocartalinica Juz.species have yet to be investigated.Our research focused on assessing the antioxidant characteristics A. methanol (MEAP) water extracts (WEAP), well their inhibitory effects acetylcholinesterase (AChE), α-glycosidase (α-gly), human carbonic anhydrase II (hCA II) enzymes.Additionally, we conducted chemical characterization using UPLC-MS/MS investigated correlation between major compounds enzymes through molecular docking analysis.To assess activities MEAP WEAP, six test systems were employed, including DPPH, ABTS, DMPD, FRAP, CUPRAC, Fe 3+ reducing assays.The outcome showed that extract plant generally has stronger activity.In addition, analysis indicated, miquelianin (44.095 mg/g), quinic acid (17.054 ellagic (6.492 mg/g) significant in extract.A study revealed a affinity binding hCAII enzyme acid, miquelianin, AChE/α-gly enzymes. pseudocatalinica high activity good inhibition effect against AChE, α-glycosidase, hCA

Язык: Английский

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Phytochemical profile and bioactive properties of sage ( Salvia fruticosa ) and thyme ( Thymus vulgaris ) extracts

International Journal of Food Properties, Год журнала: 2025, Номер 28(1)

Опубликована: Март 19, 2025

We examined the phytochemical content, antioxidant, antimicrobial, anticholinergic, antidiabetic, and antiglaucoma properties of ethanol water extracts from Salvia fruticosa (SF) Thymus vulgaris (TV). Extracts were analyzed using four antioxidant assays, while enzyme inhibition was tested against α-amylase, acetylcholinesterase (AChE), butyrylcholinesterase (BChE), human carbonic anhydrase II (hCA II). Antimicrobial activity evaluated pan-resistant bacterial strains. LC-MS/MS identified rosmarinic acid as major compound (27.61 34.35 mg/L in TV SF, respectively). Ethanolic had higher phenolic content (181.0 ± 7.86 107.0 5.78 µg GAE/mg for SF TV, showed stronger metal-reducing capacity, superior radical scavenging ability, judging by IC50 values (13.68 1.18 μg/mL), defined concentration that reduces 50% activity. The highest observed hCA (SF ethanolic extract, 14.51 4.07 AChE aqueous 16.51 3.77 BChE (TV 10.60 4.93 μg/mL). extract inhibited growth Staphylococcus aureus Enterococcus faecalis (11 mm at 60 These findings highlight potential sources natural antioxidants, inhibitors, antimicrobials pharmaceutical food formulations.

Язык: Английский

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Phytochemical Analysis, Antioxidant, Anticholinergic, Antidiabetic, and Antiglaucoma Potentials of Sage (Salvia adiyamanensis)

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Апрель 10, 2025

In this study, the antioxidant effect of ethanolic extracts were prepared from aerial part Salvia adiyamanensis was investigated through five methods, including DPPH⋅, ABTS, and Fe³⁺, Cu²⁺, Fe³⁺-TPTZ reducing assays. The IC50 values extract determined as 35.40 ± 8.35 29.50 5.12 µg/mL for DPPH ABTS radicals scavenging enzyme inhibition property against α-glycosidase, acetylcholinesterase, butyrylcholinesterase, human carbonic anhydrase I, II, a result, IC₅₀ 30.78, 191.3, 8.02, 32.68 54.82 µg/mL, respectively. LC-MS/MS revealed that S. compromised characteristic phenolics rosmarinic acid, chlorogenic luteolin, quercetin, apigenin, caffeic acid Salvia genus. These findings strongly suggest has potential to be natural medicine treatment metabolic diseases such diabetes, Alzheimer’s disease, or glaucoma.

Язык: Английский

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Antioxidants: a comprehensive review

Archives of Toxicology, Год журнала: 2025, Номер unknown

Опубликована: Апрель 15, 2025

Язык: Английский

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Phenolic Compounds in Berries of Winter-Resistant Actinidia arguta Miq. and Actinidia kolomikta Maxim.: Evidence of Antioxidative Activity

Antioxidants, Год журнала: 2024, Номер 13(3), С. 372 - 372

Опубликована: Март 19, 2024

Variations between fruit cultivars can significantly impact their biochemical composition. The present research examined the variability in qualitative and quantitative content of phenolic compounds berry extracts Actinidia kolomikta arguta cultivars. Additionally, antioxidant activities were evaluated. total phenolic, flavonoid, proanthocyanidin contents hydroxycinnamic acid derivatives determined using appropriate methodologies. average amount A. berries (177.80 mg/g) was three times higher than that (54.45 mg/g). Our findings revealed accumulated, on average, 1.58 RE/g DW (rutin equivalent/g dry weight) 0.615 mg flavonoids, 1439.31 EE/g (epicatechin 439.97 proanthocyanidins, 23.51 CAE/g (chlorogenic 5.65 derivatives, respectively. both species characterized by activity CUPRAC FRAP methods compared to ABTS•+ method. compounds’ tested evaluated applying ultra-high performance liquid chromatography (UHPLC) coupled mass spectrometry tandem with electrospray ionization. Significant intraspecific differences amounts compounds, flavonoid among Four acids, eight flavonols, two flavones, five flavon-3-ols identified extracts.

Язык: Английский

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Exploring of biological activity and diverse metabolites in hemp (Cannabis sativa) seed oil by GC/MS, GC–FID, and LC–HRMS chromatographies

Future Journal of Pharmaceutical Sciences, Год журнала: 2024, Номер 10(1)

Опубликована: Сен. 19, 2024

Abstract Background This study investigated the antidiabetic and antioxidant properties of hemp seed oil using various bioanalytical methods. Furthermore, this determined suppressive on α-amylase, acetylcholinesterase carbonic anhydrase II that purified by sepharose-4B-L-Tyrosine-sulfanilamide affinity chromatoghraphy, all which are related to different metabolic diseases. Moreover, phenolic concentration in essential was quantified through LC–HRMS chromatography. Thirteen distinct compounds were detected oil. Additionally, both chemical components quantity oils within assessed GC–FID GC/MS analyses. Results The predominant included linoleoyl chloride (34.62%), linoleic acid (33.21%), 2-4-di-tert-butylphenol (5.79%). Hemp oil's ability scavenge radicals studied use 2,2’-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) 1,1-diphenyl-2-picrylhydrazil radical scavenging results unveiled its potent radical-scavenging properties, with an 46.20 μg/mL for IC 50 9.76 radicals. investigation also extended explore reducing capabilities Fe 3+ -2,4,6-tri(2-pyridyl)-S-triazine, copper (Cu 2+ ), iron (Fe ). demonstrated notable inhibitory effect against α-amylase (IC : 545.66 μg/mL), achethylcholinesterase 28.00 322.62 μg/mL). Conclusions interdisciplinary research will prove valuable set stage future investigations into characteristics enzyme inhibition patterns plants hold medical industrial significance.

Язык: Английский

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Hamamelitannin’s Antioxidant Effect and Its Inhibition Capability on α-Glycosidase, Carbonic Anhydrase, Acetylcholinesterase, and Butyrylcholinesterase Enzymes

Processes, Год журнала: 2024, Номер 12(11), С. 2341 - 2341

Опубликована: Окт. 25, 2024

Hamamelitannin (2′,5-di-O-galloyl-hamamelose) bears two-gallate moieties in its structure, and is a natural phenolic product the leaves bark of Hamamelis virginiana. The antioxidant capacity hamamelitannin was evaluated by range methods, with following findings: ability to reduce potassium ferric cyanide; scavenging N,N-dimethyl-p-phenylenediamine dihydrochloride radical (DMPD•+); 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulphonate) (ABTS•+); 1,1-diphenyl-2-picrylhydrazyl (DPPH•); cupric ions (Cu2+). Additionally, reference antioxidants α-Tocopherol, butylated hydroxyanisole (BHA), Trolox, hydroxytoluene (BHT) were used for comparison. For DPPH scavenging, had an IC50 value 19.31 μg/mL, while values BHA, BHT, α-Tocopherol 10.10, 25.95, 7.05, 11.31 respectively. study found that functioned similarly α-tocopherol, Trolox terms DPPH• but better than BHT. as polyphenolic secondary metabolite, inhibition capability several metabolic enzymes demonstrated, including acetylcholinesterase (AChE), butyrylcholinesterase (BChE), carbonic anhydrase I (CA I), II II) α-glycosidase. Ki exhibited 7.40, 1.99, 10.18, 18.26, 25.79 nM toward AChE, BChE, hCA I, II, α-glycosidase,

Язык: Английский

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Flavor Quality Analysis of Ten Actinidia arguta Fruits Based on High-Performance Liquid Chromatography and Headspace Gas Chromatography–Ion Mobility Spectrometry

Molecules, Год журнала: 2023, Номер 28(22), С. 7559 - 7559

Опубликована: Ноя. 13, 2023

Actinidia arguta is a fruit crop with high nutritional and economic value. However, its flavor quality depends on various factors, such as variety, environment, post-harvest handling. We analyzed the composition of total soluble sugars, titratable acids, organic substances in fruits ten A. varieties. The sugar content ranged from 4.22 g/L to 12.99 g/L, acid 52.55 89.9 sugar-acid ratio 5.39 14.17 at soft ripe stage. High-performance liquid chromatography (HPLC) showed that citric, quinic, malic acids were main fruits. Headspace gas chromatography-ion mobility spectrometry (HS-GC-IMS) detected 81 volatile compounds 10 varieties, including 24 esters, 17 alcohols, 23 aldehydes, 7 ketones, 5 terpenes, 2 1 Pyrazine, furan, benzene. Esters aldehydes had highest relative compounds. An orthogonal partial least squares discriminant analysis (OPLS-DA) based odor activity value (OAV) revealed myrcene, benzaldehyde, methyl isobutyrate, α-phellandrene, 3-methyl butanal, valeraldehyde, ethyl butyrate, acetoin, (E)-2-octenal, hexyl propanoate, terpinolene, 1-penten-3-one, butyrate contributors differences aroma profiles different Ten varieties have flavors. This study can clarify between provide reference for evaluation flavor, variety improvement new selection.

Язык: Английский

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