Dubai Medical Journal,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 8, 2024
Introduction:
Amyotrophic
lateral
sclerosis
(ALS),
a
neurodegenerative
disease
that
causes
muscle
weakness,
paralysis,
and
death,
develops
when
motor
neurons
begin
to
die.
There
are
few
proven
treatments
for
ALS,
because
the
is
incurable,
exact
cause
unknown,
making
it
devastating
condition.
According
recent
research,
marine
algae
may
contain
bioactive
substances
can
be
used
treat
ALS.
Methods:
The
comprehensive
review
of
publications
focused
on
compounds
extracted
from
various
species
algae,
including
their
mechanisms
action
against
oxidative
stress,
neuroinflammation,
apoptosis
in
were
reviewed
scientific
journals
(ScienceDirect,
Springer,
Taylor
&
Francis,
MDPI)
indexed
several
databases
(Scopus,
Web
Science,
PubMed,
Google
Scholar,
so
on).
Discussion:
Compounds
derived
polyunsaturated
fatty
acids,
fucoxanthin,
polysaccharides,
exhibit
potential
neuroprotective
effects
by
modulating
neuroinflammation
stress
levels.
Fucoxanthin,
fucosterol,
alginate
demonstrated
mitigating
damage
inflammation,
which
critical
factors
pathogenesis
Conclusion:
Bioactive
obtained
demonstrate
considerable
as
therapeutic
agents
owing
capacity
influence
multiple
pathways
linked
neuroinflammation.
Further
investigation
required
comprehend
medicinal
value,
well
develop
novel
alternative
Journal of Food Composition and Analysis,
Год журнала:
2024,
Номер
133, С. 106453 - 106453
Опубликована: Июнь 22, 2024
Seaweeds
are
an
important
natural
source
of
highly
valuable
bioactive
compounds,
namely
vitamins,
proteins,
essential
amino
acids,
omega-3
polyunsaturated
fatty
minerals
and
trace
elements,
carotenoids,
polyphenols,
enzymes
carbohydrates.
Their
compounds
have
been
associated
to
several
biological
activities,
such
as
antioxidant,
anticancer,
antidiabetic,
antimicrobial,
anticoagulant,
antiviral,
anti-inflammatory,
immunomodulatory,
prebiotic,
hypocholesterolemic.
Due
their
richness
in
well-balanced
composition,
seaweeds
become
a
promising
innovative
new
functional
ingredients,
that
can
be
used
the
development
novel
food
products
well
nutraceuticals,
thus,
improving
human
health,
well-being
quality
life,
also
contributing
prevention
treatment
diseases.
This
review
provides
overview
knowledge
acquired
last
years
about
health
benefits
with
molecules,
consumption
seaweeds-based
foods
nutraceuticals.
Marine Drugs,
Год журнала:
2024,
Номер
22(10), С. 433 - 433
Опубликована: Сен. 25, 2024
Inflammation
is
considered
as
one
of
the
most
primary
protective
innate
immunity
responses,
closely
related
to
body’s
defense
mechanism
for
responding
chemical,
biological
infections,
or
physical
injuries.
Furthermore,
prolonged
inflammation
undesirable,
playing
an
important
role
in
development
various
diseases,
such
heart
disease,
diabetes,
Alzheimer’s
atherosclerosis,
rheumatoid
arthritis,
and
even
certain
cancers.
Marine-derived
fungi
represent
promising
sources
structurally
novel
bioactive
natural
products,
have
been
a
focus
research
anti-inflammatory
drugs.
This
review
covers
secondary
metabolites
with
activities
from
marine-derived
fungi,
over
period
spanning
August
2018
July
2024.
A
total
285
metabolites,
including
156
compounds
11
skeleton
structures,
are
described.
Their
structures
categorized
into
five
categories:
terpenoids,
polyketides,
nitrogen-containing
compounds,
steroids,
other
classes.
The
targets,
well
vitro
vivo
screening
models,
were
surveyed
statistically
summarized.
paper
aims
offer
valuable
insights
researchers
exploration
products
discovery
Marine Drugs,
Год журнала:
2024,
Номер
22(7), С. 304 - 304
Опубликована: Июнь 28, 2024
From
sea
shores
to
the
abysses
of
deep
ocean,
marine
ecosystems
have
provided
humanity
with
valuable
medicinal
resources.
The
use
organisms
is
discussed
in
ancient
pharmacopoeias
different
times
and
geographic
regions
still
deeply
rooted
traditional
medicine.
Thanks
present-day,
large-scale
bioprospecting
rigorous
screening
for
bioactive
metabolites,
ocean
coming
back
as
an
untapped
resource
natural
compounds
therapeutic
potential.
This
renewed
interest
drugs
propelled
by
a
burgeoning
research
field
investigating
molecular
mechanisms
which
newly
identified
intervene
pathophysiology
human
diseases.
Of
great
clinical
relevance
are
molecules
endowed
anti-inflammatory
immunomodulatory
properties
emerging
applications
management
chronic
inflammatory
disorders,
autoimmune
diseases,
cancer.
Here,
we
review
historical
development
pharmacology
Eastern
Western
worlds
describe
status
drug
discovery.
Finally,
discuss
importance
conducting
sustainable
exploitation
resources
through
biotechnology.
Critical Reviews in Food Science and Nutrition,
Год журнала:
2025,
Номер
unknown, С. 1 - 18
Опубликована: Фев. 4, 2025
Algae,
a
crucial
constituent
of
marine
systems,
serve
an
indispensable
function
as
primary
producers,
supporting
the
food
web,
contributing
to
carbon
sequestration,
and
providing
habitats
that
sustain
biodiversity.
This
review
focuses
on
bioactive
constituents
algae,
including
polysaccharides,
polyphenols,
polypeptides,
terpenoid
compounds,
discusses
their
potential
applications
in
treating
immune-related
diseases,
well
mechanisms
through
which
they
modulate
immune
responses.
The
substances
derived
from
peptides,
terpenes,
polysaccharides
other
may
play
preventive
role
by
modulating
allergic
responses
reducing
incidence
inflammation
cancer.
Stresses,
Год журнала:
2025,
Номер
5(1), С. 22 - 22
Опубликована: Март 5, 2025
Marine
macroalgae
(commonly
known
as
seaweeds),
a
rich
yet
underexplored
resource,
have
emerged
promising
source
of
bioactive
compounds
with
potent
antioxidant
properties.
While
oxidative
stress
is
critical
factor
in
the
pathogenesis
numerous
chronic
diseases,
including
neurodegenerative
disorders,
cardiovascular
conditions,
and
cancer,
macroalgae-derived
such
polyphenols,
carotenoids,
peptides,
sulfated
polysaccharides
demonstrated
ability
to
mitigate
damage
through
multifaceted
mechanisms.
These
neutralize
reactive
oxygen
species
modulate
key
cellular
pathways
involved
inflammation
apoptosis.
Despite
significant
advancements,
gaps
persist
understanding
pharmacokinetics,
bioavailability,
clinical
applications
these
bioactives.
Additionally,
inefficiencies
traditional
extraction
methods
call
for
adopting
innovative,
environmentally
friendly
techniques
that
preserve
bioactivity.
This
review
synthesizes
current
knowledge
on
therapeutic
potential
macroalgal
bioactives,
acknowledges
contributions
other
marine
algae
where
relevant,
highlights
challenges
their
extraction,
proposes
future
directions
research
application.
