Fumaria officinalis Dust as a Source of Bioactives for Potential Dermal Application: Optimization of Extraction Procedures, Phytochemical Profiling, and Effects Related to Skin Health Benefits

Plants, Год журнала: 2025, Номер 14(3), С. 352 - 352

Опубликована: Янв. 24, 2025

Fumaria officinalis (fumitory), in the form of dust, was employed as a source bioactive extracts whose chemical profile and biological potential were investigated. According to results optimization extraction protocol, extract with highest polyphenol yield prepared using fumitory dust under optimal conditions determined statistical tool, 23 full factorial design: 50% ethanol 30:1 mL/g ratio during 120 s microwave (22.56 mg gallic acid equivalent/g plant material). LC-MS spectrophotometric/gravimetric analyses quantified polyphenol, flavonoid, tannin, alkaloid, protein contents. Caffeoylmalic acid, quercetin dihexoside, pentoside hexoside, rutin, methylquercetin dihexoside most dominant compounds. The total condensed yields microwaves. In addition proven antioxidant potential, present study, anti-inflammatory activity is also keratinocyte model, well significant reduction H2O2-induced reactive oxygen species production cells absence cytotoxicity. Thus, detailed profiles investigated effects related skin health benefits encourage application dermo-cosmetic pharmaceutical preparations for dermatological circumstances.

Язык: Английский

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Green Synthesis and Characterization of Silver and Gold Nanoparticles Using Echinophora platyloba Extract and Evaluation of Their Anti‐Inflammatory and Antioxidant Properties

Oxidative Medicine and Cellular Longevity, Год журнала: 2025, Номер 2025(1)

Опубликована: Янв. 1, 2025

This study intends to investigate the green synthesis of silver (Ag) and gold (Au) nanoparticles (NPs) using Echinophora platyloba extract evaluate antioxidant anti‐inflammatory effects synthesized NPs extract. In this study, aqueous hydroalcoholic extracts E. were prepared, which used for biosynthesis Ag Au NPs. Dynamic light scattering (DLS), zeta potential analysis, transmission electron microscopy (TEM), Fourier transform infrared (FT‐IR) spectroscopy, UV‐Vis X‐ray diffraction (XRD) methods characterize The effect was estimated in vitro methods, including reducing power (RP), ferric reducing/antioxidant (FRAP), 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH). To activity NPs, we carrageenan method. our experiment, administered orally mice 2 h before injection. subsequent inhibition inflammation reduction paw thickness quantified. their effect, malondialdehyde (MDA), total capacity (TAC) levels measured. Levels pro‐inflammatory cytokines, interleukin‐6 (IL‐6) tumor necrosis factor‐ α (TNF‐ ), also results indicate that have effects. most promising observed groups received

Язык: Английский

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Neuroprotective Potentials of Marine Algae and Their Bioactive Metabolites: Pharmacological Insights and Therapeutic Advances

Опубликована: Май 21, 2020

Beyond their significant contribution to the dietary and industrial supplies, marine algae are considered be a potential source of some unique metabolites with diverse health benefits. The pharmacological properties, such as antioxidant, anti-inflammatory, cholesterol homeostasis, protein clearance anti-amyloidogenic potentials algal endorse protective efficacy against oxidative stress, neuroinflammation, mitochondrial dysfunction, impaired proteostasis which known implicated in pathophysiology neurodegenerative disorders associated complications after cerebral ischemia brain injuries. As was evident various preclinical studies, compounds conferred neuroprotection wide range neurotoxic stressors, oxygen/glucose deprivation, hydrogen peroxide, glutamate, amyloid β, or 1-methyl-4-phenylpyridinium (MPP+) and, therefore, hold therapeutic promise for disorders. While number promising neuroprotective capacity have been identified over last decades, few them had access clinical trials. However, recent approval an oligosaccharide, sodium oligomannate, treatment Alzheimer's disease enlightened future algae-based drug discovery. In this review, we briefly outline diseases injuries identifying targets intervention, then review literature on along underlying mechanism, present appraisal advances. We also propose rational strategy facilitate metabolites-based development.

Язык: Английский

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Chemical Diversity of Soft Coral Steroids and Their Pharmacological Activities

Marine Drugs, Год журнала: 2020, Номер 18(12), С. 613 - 613

Опубликована: Дек. 2, 2020

The review is devoted to the chemical diversity of steroids produced by soft corals and their determined potential activities. There are about 200 that belong different types such as secosteroids, spirosteroids, epoxy- peroxy-steroids, steroid glycosides, halogenated steroids, polyoxygenated containing sulfur or nitrogen heteroatoms. Of greatest interest pharmacological activity these steroids. More than 40 exhibit antitumor related with a confidence level over 90 percent. A group 32 shows anti-hypercholesterolemic percent confidence. Ten anti-inflammatory 20 can be classified respiratory analeptic drugs. Several rather rare very specific Steroids anti-osteoporotic properties used treat osteoporosis, well have strong anti-eczemic anti-psoriatic antispasmodic properties. Thus, this probably first exclusive present known activities marine

Язык: Английский

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Variation in Anti-inflammatory, Anti-arthritic, and Antimicrobial Activities of Different Extracts of Common Egyptian Seaweeds with an Emphasis on Their Phytochemical and Heavy Metal Contents

Biological Trace Element Research, Год журнала: 2022, Номер 201(4), С. 2071 - 2087

Опубликована: Июнь 4, 2022

Abstract The anti-inflammatory, anti-arthritic, and antimicrobial activities of some common Egyptian seaweeds in addition to their phytochemical heavy metal contents were investigated. Phytochemical screening the seaweed extracts showed presence different primary secondary metabolites with concentrations according species used solvent. ethanolic extract Colpmenia sinuosa (CSBE2) exhibited maximum anti-inflammatory anti-arthritic activity at 1000 μg/ml concentration compared other extracts. dichloromethane Corallina officinalis (CORM) exerted highest an average inhibition zone diameter (AV) = 15.29 mm index (AI) 1.53 antagonistic against Escherichia coli (28 mm). It is followed by Ulva linza (ULGE2) which recorded 14.71 1.30 antifungal Candida albicans (30 collected would therefore be a very promising source for treating inflammatory, arthritic, microbial diseases. Moreover, investigated variable metals among various species. mean took following order: Fe > Zn Mn Ba Cu As Cr Ni Pb V Cd Se Co Mo. Based on permissible limits set WHO CEVA, studied found within limits, whereas borderline. Significant correlations observed between parameters. estimated daily intakes most lower than recommended intakes.

Язык: Английский

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Artificial Seaweed Reefs That Support the Establishment of Submerged Aquatic Vegetation Beds and Facilitate Ocean Macroalgal Afforestation: A Review

Journal of Marine Science and Engineering, Год журнала: 2022, Номер 10(9), С. 1184 - 1184

Опубликована: Авг. 24, 2022

Macroalgae are invaluable constituents of marine forest environments and important sources material for human needs. However, they currently at risk severe decline due to global warming negative anthropogenic factors. Restoration efforts focus on beds where macroalgae previously existed, as well the creation new forests. Some artificial seaweed reefs (ASRs) have succeeded but others failed; contributions ASRs formation been not fully determined. Here, we review ASRs, benefits macroalgal forests, threats macroalgae, restoration, explore current status ASRs. The published literature indicates that played critical roles in formation; notably, support establishment submerged aquatic vegetation allow ocean afforestation. evolved terms complexity materials used; can sustainably mitigate deforestation. continuous reviews ASR performance essential, improvements always possible.

Язык: Английский

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Anti-Inflammatory Effects of Bioactive Compounds from Seaweeds, Bryozoans, Jellyfish, Shellfish and Peanut Worms

Marine Drugs, Год журнала: 2023, Номер 21(10), С. 524 - 524

Опубликована: Сен. 30, 2023

Inflammation is a defense mechanism of the body in response to harmful stimuli such as pathogens, damaged cells, toxic compounds or radiation. However, chronic inflammation plays an important role pathogenesis variety diseases. Multiple anti-inflammatory drugs are currently available for treatment inflammation, but all exhibit less efficacy. This drives search new focusing on natural resources. Marine organisms produce broad spectrum bioactive with activities. Several considered lead development into drugs. Anti-inflammatory have been extracted from algae, corals, seaweeds and other marine organisms. We previously reviewed compounds, well crude extracts isolated echinoderms sea cucumbers, urchins starfish. In present review, we evaluate effects organisms, including macroalgae (seaweeds), angiosperms (seagrasses), medusozoa (jellyfish), bryozoans (moss animals), mollusks (shellfish) peanut worms. also review molecular mechanisms activity these compounds. Our objective this provide overview current state research sources prospects their translation novel

Язык: Английский

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Marine Pharmacology in 2019–2021: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

Marine Drugs, Год журнала: 2024, Номер 22(7), С. 309 - 309

Опубликована: Июнь 30, 2024

The current 2019-2021 marine pharmacology literature review provides a continuation of previous reviews covering the period 1998 to 2018.

Язык: Английский

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Onosma mutabilis: Phytochemical composition, antioxidant, cytotoxicity, and acute oral toxicity

Food Science & Nutrition, Год журнала: 2021, Номер 9(10), С. 5755 - 5764

Опубликована: Авг. 28, 2021

Abstract The traditional use of Onosma L. species as a remedy motivated scientists to discover great biological/pharmacological potentials in this plant. In the current study, addition phytochemical composition methanol (MeOH), water, and ethyl acetate extract aerial parts mutabilis Boiss., an endemic plant flora Kurdistan, Iraq, vitro antioxidant, cytotoxicity, oral toxicity activity were investigated. Results total phenolic flavonoid tests show MeOH superiority, results Gas chromatography–mass spectrophotometer(GS/GS‐MS) 18 chemical compounds extract, majority detected alkaloids (78.77%) steroids (11.48%), namely 5,8‐dihydroxy‐2‐(4‐methylpent‐3‐enyl) naphthalene‐1,4‐dione (48.60%), 3‐O‐Methyl‐d‐glucose (27.49%), β‐Sitosterol (6.81%), Phenol, 2,4‐bis (1,1‐dimethyl ethyl)‐, phosphite (3.46%), 24,25‐Dihydroxycholecalciferol (3.14%). antioxidant superiority phosphomolybdenum assay, radical scavenging [on 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) 2,2′‐azino‐bis (3‐ethylbenzothiazoline‐6‐sulfonic acid) (ABTS)] assays, reducing power [cupric capacity (CUPRAC) ferric (FRAP)] assays (1.45, 3.54, 2.33, 1.12, 1.62, mg/ml, respectively). cytotoxicity are presented IC 50 (inhibitory concentration at 50%) on prostate cancer cells (DU‐145), mammary (MCF‐7), human cervix carcinoma (Hep2c), which values ranged from 28.79 41.83 μg/ml. acute dose‐dependent trail (100, 200, 300, 600 mg/kg MeOH) absence behavior appearance changes female Wister rats. Overall, O. exhibited significant natural probably because its polar phytochemicals, could be alternative source for remedial, nutrient, cosmetic manufacture.

Язык: Английский

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Antibacterial and antioxidant efficacy of ethyl acetate extract of Cymodocea serrulata and assess the major bioactive components in the extract using GC-MS analysis

Process Biochemistry, Год журнала: 2022, Номер 124, С. 24 - 32

Опубликована: Ноя. 3, 2022

Язык: Английский

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