Multifunctional roles and pharmacological potential of β-sitosterol: Emerging evidence toward clinical applications

Chemico-Biological Interactions, Год журнала: 2022, Номер 365, С. 110117 - 110117

Опубликована: Авг. 19, 2022

Язык: Английский

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Phytochemicals, Nutrition, Metabolism, Bioavailability, and Health Benefits in Lettuce—A Comprehensive Review

Antioxidants, Год журнала: 2022, Номер 11(6), С. 1158 - 1158

Опубликована: Июнь 13, 2022

Lettuce is one of the most famous leafy vegetables worldwide with lots applications from food to other specific uses. There are different types in lettuce group for consumers choose from. Additionally, an excellent source bioactive compounds such as polyphenols, carotenoids, and chlorophyll related health benefits. At same time, nutrient composition antioxidant between varieties, especially green red types. The benefit consumption depends on its composition, particularly antioxidants, which can function nutrients. benefits rely their biochemical effect when reaching bloodstream. Some components be released matrix altered digestive system. Indeed, bioaccessibility measuring quantity these during digestion, important health-promoting features. Extraction new trends observed necessarily used several application fields. Therefore, this review aims demonstrate nutritional value pharmacological properties. Due bioavailability, consumer will able comprehensively understand choosing a healthier diet. common utilization pattern extracted nutrients also summarized further direction.

Язык: Английский

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Prospective multifunctional roles and pharmacological potential of dietary flavonoid narirutin

Biomedicine & Pharmacotherapy, Год журнала: 2022, Номер 150, С. 112932 - 112932

Опубликована: Апрель 9, 2022

Plant-based phytochemicals are now being used to treat plenty of physiological diseases. Herbal drugs have gained popularity in recent years because their strength, purity, and cheap cost-effectiveness. Citrus fruits contain significant amounts flavanones, which falls the category polyphenols. Flavanones occupy a major fraction total polyphenols present plasma when orange juice is taken highly or moderate states. Narirutin disaccharide derivative available citrus fruits, primarily dihydroxy flavanone. From pharmacological viewpoint, narirutin bioactive phytochemical with therapeutic efficacy. Many experimental researches were published on use narirutin. Anticancer activity, neuroprotection, stress relief, hepatoprotection, anti-allergic antidiabetic anti-adipogenic anti-obesity action, immunomodulation couple primary properties. also has antioxidant, anti-inflammatory activities. The ultimate goal this review provide current scenario research narirutin; make better understanding for potential narirutin, as well its biosynthesis strategies side effects. Extensive literature searches studies undertaken determine properties

Язык: Английский

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Exploring the journey of emodin as a potential neuroprotective agent: Novel therapeutic insights with molecular mechanism of action

Biomedicine & Pharmacotherapy, Год журнала: 2022, Номер 149, С. 112877 - 112877

Опубликована: Март 31, 2022

Emodin is an anthraquinone derivative found in the roots and bark of a variety plants, molds, lichens. has been used as traditional medication for more than 2000 years still common numerous herbal drugs. plentiful three plant families, including Polygonaceae (Rheum, Rumex, Polygonum spp.), Fabaceae (Cassia Rhamnaceae (Rhamnus, Frangula, Ventilago spp.). Emerging experimental evidences indicate that emodin confers wide range pharmacological activities; special focus was implemented toward neurodegenerative diseases, Alzheimer's disease, Parkinson's cerebral ischemia, anxiety depression, schizophrenia, chronic hyperglycemic peripheral neuropathy, etc. Numerous preclinical were established support neuroprotection emodin. However, this review highlighted role potent neurotherapeutic agent; therefore, its evidence-based functionality on neurological disorders (NDs).

Язык: Английский

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Allium cepa: A Treasure of Bioactive Phytochemicals with Prospective Health Benefits

Evidence-based Complementary and Alternative Medicine, Год журнала: 2022, Номер 2022, С. 1 - 27

Опубликована: Янв. 18, 2022

As Allium cepa is one of the most important condiment plants grown and consumed all over world, various therapeutic pharmacological effects A. were reviewed. Onion (Allium cepa) a high dietary fiber-rich perennial herb that placed under family Amaryllidaceae. It contains concentration folic acid, vitamin B6, magnesium, calcium, potassium, phosphorus as well vitamins minerals. widely used an antimicrobial agent, but it showed anticancer, antidiabetic, antioxidant, antiplatelet, antihypertensive, antidepressant neuroprotective, anti-inflammatory, antiparasitic so on. said to have beneficial on digestive, circulatory, respiratory systems, immune system. This review article was devoted discussing many health benefits traditional uses onions in perspectives, safety/toxicological profile. If more detailed research this conducted, will open door infinite number possibilities.

Язык: Английский

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l-carnitine: Nutrition, pathology, and health benefits

Saudi Journal of Biological Sciences, Год журнала: 2022, Номер 30(2), С. 103555 - 103555

Опубликована: Дек. 30, 2022

Carnitine is a medically needful nutrient that contributes in the production of energy and metabolism fatty acids. Bioavailability higher vegetarians than people who eat meat. Deficits carnitine transporters occur as result genetic mutations or combination with other illnesses such like hepatic renal disease. deficit can arise diseases endocrine maladies, cardiomyopathy, diabetes, malnutrition, aging, sepsis, cirrhosis due to abnormalities regulation. The exogenously provided molecule obviously useful primary deficits, which be life-threatening, also some secondary deficiencies, including organic acidurias: by eradicating hypotonia, muscle weakness, motor skills, wasting are all improved l-carnitine (LC) have reported improve myocardial functionality ischemic heart disease patients, well athletic performance individuals angina pectoris. Furthermore, although intriguing data indicates LC could variety conditions, deficiency caused long-term total parenteral supplementation chronic hemodialysis, hyperlipidemias, prevention anthracyclines valproate-induced toxicity, findings must viewed caution.

Язык: Английский

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The Role of Astaxanthin as a Nutraceutical in Health and Age-Related Conditions

Molecules, Год журнала: 2022, Номер 27(21), С. 7167 - 7167

Опубликована: Окт. 23, 2022

The current review provides an up-to-date analysis of scientific data on astaxanthin (ASX) sources and experimental studies its health benefits as a potent antioxidant in the aging process. ASX is liposoluble carotenoid nutrient reddish-orange pigment, naturally synthesized by numerous microalgae, yeasts, bacteria secondary metabolites. Provides reddish hue to redfish shellfish flesh that feed ASX-producing microorganisms. microalga Haematococcus pluvialis most important source for industrial bioproduction. Due strong properties, investigations reported natural more significant agent than other antioxidants, such vitamin C, E, β-carotene. Furthermore, several show possesses nutraceutical applications benefits, especially healthy processes. However, further are needed deeper understanding potential mechanisms through which could lead effective role process, supporting brain skin homeostasis. This highlights oxidative stress, mechanisms, physiology, central nervous system functioning, shows clinical implications related consumption.

Язык: Английский

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Mesoporous silica nanoparticles: Their potential as drug delivery carriers and nanoscavengers in Alzheimer's and Parkinson's diseases

Saudi Pharmaceutical Journal, Год журнала: 2023, Номер 31(3), С. 417 - 432

Опубликована: Фев. 1, 2023

Worldwide, populations face significant burdens from neurodegenerative disorders (NDDs), especially Alzheimer's and Parkinson's diseases. Although there are many proposed etiologies for disorders, including genetic environmental factors, the exact pathogenesis these is not fully understood. Most patients with NDDs given lifelong treatment to improve their quality of life. There myriad treatments NDDs; however, agents limited by side effects difficulty in passing blood-brain barrier (BBB). Furthermore, central nervous system (CNS) active pharmaceuticals could offer symptomatic relief patient's condition without providing a complete cure or prevention targeting disease's cause. Recently, Mesoporous silica nanoparticles (MSNs) have gained interest treating since physicochemical properties inherent ability pass BBB make them possible drug carriers several drugs treatment. This paper provides insight into NDDs, along recent advances applying MSNs as fibril scavengers. Moreover, application MSNs-based formulations enhancing sustaining release rate, brain via responsive properties, besides neurotoxicity MSNs, been reviewed.

Язык: Английский

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Michael Acceptors as Anti-Cancer Compounds: Coincidence or Causality?

International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(11), С. 6099 - 6099

Опубликована: Июнь 1, 2024

Michael acceptors represent a class of compounds with potential anti-cancer properties. They act by binding to nucleophilic sites in biological molecules, thereby disrupting cancer cell function and inducing death. This mode action, as well their ability be modified targeted, makes them promising avenue for advancing therapy. We are investigating the molecular mechanisms underlying interactions cells, particular interfere cellular processes induce apoptosis. The properties not accidental but due chemical structure reactivity. electrophilic nature these allows selectively target residues on disease-associated proteins, resulting significant therapeutic benefits minimal toxicity various diseases. opens up new perspectives development more effective precise drugs. Nevertheless, further studies essential fully understand impact our discoveries translate into clinical practice.

Язык: Английский

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Anti-Alzheimer’s Molecules Derived from Marine Life: Understanding Molecular Mechanisms and Therapeutic Potential

Marine Drugs, Год журнала: 2021, Номер 19(5), С. 251 - 251

Опубликована: Апрель 28, 2021

Alzheimer’s disease (AD) is a devastating neurodegenerative and the most common cause of dementia. It has been confirmed that pathological processes intervene in AD development are linked with oxidative damage to neurons, neuroinflammation, tau phosphorylation, amyloid beta (Aβ) aggregation, glutamate excitotoxicity, cholinergic deficit. Still, there no available therapy can cure AD. Available therapies only manage some symptoms at early stages Various studies have revealed bioactive compounds derived from marine organisms plants exert neuroprotective activities fewer adverse events, as compared synthetic drugs. Furthermore, identified source novel therapeutic potential. Thus, growing interest regarding sources anti-AD potentials. drugs including bryostatin-1, homotaurine, anabaseine its derivative, rifampicins, anhydroexfoliamycin, undecylprodigioisin, gracilins, 13-desmethyl spirolide-C, dictyostatin displayed excellent bioavailability efficacy against Most these were found be well-tolerated patients, along significant drug-associated events. In this review, we focus on life useful treatment also summarize agents currently used treat

Язык: Английский

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